Researchers at the University of Pittsburgh Cancer Institute (UPCI), in collaboration with Johns Hopkins University School of Medicine have found that a recently discovered gene plays an essential role in mediating apoptosis, or cell death, in colorectal cancer cells. The results are published in the Feb. 18 issue of Proceedings of the National Academy of Sciences.
The gene, PUMA, or p53 up-regulated modulator of apoptosis, is controlled by p53 – a tumor-suppressing gene that prevents normal cells from turning into life-threatening tumor cells. Previous research has determined that damage to p53 is fundamental to the development of a vast majority of cancers, and inactivation of the growth-controlling function of p53 is critical to the growth and spread of most cancers.
The leading investigators of the study, Lin Zhang, Ph.D., assistant professor of pharmacology, University of Pittsburgh and Jian Yu, Ph.D., assistant professor of pathology, University of Pittsburgh, performed several gene targeting experiments involving PUMA and found that if the gene is deleted in colorectal cancer cells, cell death is prevented. These findings build on previous findings published in 2001 in Molecular Cell, where the same research team identified PUMA as a novel gene that when expressed, resulted in rapid and profound apoptosis.
Neutrons produce first direct 3D maps of water during cell membrane fusion
21.09.2018 | DOE/Oak Ridge National Laboratory
Narcolepsy, scientists unmask the culprit of an enigmatic disease
20.09.2018 | Universitätsspital Bern
The building blocks of matter in our universe were formed in the first 10 microseconds of its existence, according to the currently accepted scientific picture. After the Big Bang about 13.7 billion years ago, matter consisted mainly of quarks and gluons, two types of elementary particles whose interactions are governed by quantum chromodynamics (QCD), the theory of strong interaction. In the early universe, these particles moved (nearly) freely in a quark-gluon plasma.
This is a joint press release of University Muenster and Heidelberg as well as the GSI Helmholtzzentrum für Schwerionenforschung in Darmstadt.
Then, in a phase transition, they combined and formed hadrons, among them the building blocks of atomic nuclei, protons and neutrons. In the current issue of...
Thin-film solar cells made of crystalline silicon are inexpensive and achieve efficiencies of a good 14 percent. However, they could do even better if their shiny surfaces reflected less light. A team led by Prof. Christiane Becker from the Helmholtz-Zentrum Berlin (HZB) has now patented a sophisticated new solution to this problem.
"It is not enough simply to bring more light into the cell," says Christiane Becker. Such surface structures can even ultimately reduce the efficiency by...
A study in the journal Bulletin of Marine Science describes a new, blood-red species of octocoral found in Panama. The species in the genus Thesea was discovered in the threatened low-light reef environment on Hannibal Bank, 60 kilometers off mainland Pacific Panama, by researchers at the Smithsonian Tropical Research Institute in Panama (STRI) and the Centro de Investigación en Ciencias del Mar y Limnología (CIMAR) at the University of Costa Rica.
Scientists established the new species, Thesea dalioi, by comparing its physical traits, such as branch thickness and the bright red colony color, with the...
Scientists have succeeded in observing the first long-distance transfer of information in a magnetic group of materials known as antiferromagnets.
An international team of researchers has mapped Nemo's genome, providing the research community with an invaluable resource to decode the response of fish to...
03.09.2018 | Event News
27.08.2018 | Event News
17.08.2018 | Event News
21.09.2018 | Trade Fair News
21.09.2018 | Earth Sciences
21.09.2018 | Health and Medicine