When developing a treatment plan for cervical cancer, it is important to be able to determine a patients prognosis, ideally at the time of diagnosis. Existing methods to arrive at a prognosis can be time consuming, inaccurate and may require specialized software. Therefore, doctors from the Washington University School of Medicine developed – and validated – an accurate, reproducible and quick prognostic system.
The researchers created a grading scale to use in conjunction with a simple visual analysis of 18F-FDG PET scans. The grading system considered the size and shape of the primary tumor, as well as the heterogeneity of 18F-FDG uptake and presence of lymph nodes. A cutoff value was established to separate the women with "good" and "bad" prognoses, and Kaplan-Meier analysis provided a guideline both for progression-free survival and for overall survival. Researchers also examined whether knowledge about the presence of lymph notes impacted the efficacy of the system.
The retrospective study was conducted using data from 47 patients. Three independent observers, who had no knowledge of the patients, evaluated and graded the PET scans. The close scores and survival prognoses of the three observers demonstrated the reproducibility of the test. A comparison of the observers projected outcomes and the actual outcomes verified the accuracy and the power of this visual analysis; for example, 80% of those women who were predicted to have a bad diagnosis did not survive while only 10% with a good prognosis died. The information about the presence of lymph nodes increased the accuracy only slightly compared to the analysis of tumor characteristics alone.
Kimberly A. Bennett | EurekAlert!
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24.05.2019 | Schwedischer Forschungsrat - The Swedish Research Council
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22.05.2019 | Technische Universität Berlin
A new assessment of NASA's record of global temperatures revealed that the agency's estimate of Earth's long-term temperature rise in recent decades is accurate to within less than a tenth of a degree Fahrenheit, providing confidence that past and future research is correctly capturing rising surface temperatures.
The most complete assessment ever of statistical uncertainty within the GISS Surface Temperature Analysis (GISTEMP) data product shows that the annual values...
Physicists at the University of Basel are able to show for the first time how a single electron looks in an artificial atom. A newly developed method enables them to show the probability of an electron being present in a space. This allows improved control of electron spins, which could serve as the smallest information unit in a future quantum computer. The experiments were published in Physical Review Letters and the related theory in Physical Review B.
The spin of an electron is a promising candidate for use as the smallest information unit (qubit) of a quantum computer. Controlling and switching this spin or...
Engineers at the University of Tokyo continually pioneer new ways to improve battery technology. Professor Atsuo Yamada and his team recently developed a...
With a quantum coprocessor in the cloud, physicists from Innsbruck, Austria, open the door to the simulation of previously unsolvable problems in chemistry, materials research or high-energy physics. The research groups led by Rainer Blatt and Peter Zoller report in the journal Nature how they simulated particle physics phenomena on 20 quantum bits and how the quantum simulator self-verified the result for the first time.
Many scientists are currently working on investigating how quantum advantage can be exploited on hardware already available today. Three years ago, physicists...
'Quantum technologies' utilise the unique phenomena of quantum superposition and entanglement to encode and process information, with potentially profound benefits to a wide range of information technologies from communications to sensing and computing.
However a major challenge in developing these technologies is that the quantum phenomena are very fragile, and only a handful of physical systems have been...
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