By solving a long-standing puzzle about how the influenza virus assembles its genetic contents into infectious particles that enable the virus to spread from cell to cell, scientists have opened a new gateway to a better understanding of one of the worlds most virulent diseases.
This insight into the genetic workings that underpin infection by flu, reported today (January 27, 2003) in the Proceedings of the National Academy of Sciences (PNAS), provides not only a better basic understanding of how flu and other viruses work, but holds significant promise for new and better vaccines and drugs to combat the disease by exposing the genetic trick it uses to form virus particles.
The new work is reported by a group led by Yoshihiro Kawaoka, a professor of pathobiological sciences at the University of Wisconsin-Madison School of Veterinary Medicine, who has a joint appointment at the University of Tokyo. The groups work describes how the flu virus selectively assembles the series of genetic subunits that make up the virus entire genome, which are needed to form the particles that shuttle the virus from cell to cell.
Yoshihiro Kawaoka | EurekAlert!
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Abnormal scarring is a serious threat resulting in non-healing chronic wounds or fibrosis. Scars form when fibroblasts, a type of cell of connective tissue, reach wounded skin and deposit plugs of extracellular matrix. Until today, the question about the exact anatomical origin of these fibroblasts has not been answered. In order to find potential ways of influencing the scarring process, the team of Dr. Yuval Rinkevich, Group Leader for Regenerative Biology at the Institute of Lung Biology and Disease at Helmholtz Zentrum München, aimed to finally find an answer. As it was already known that all scars derive from a fibroblast lineage expressing the Engrailed-1 gene - a lineage not only present in skin, but also in fascia - the researchers intentionally tried to understand whether or not fascia might be the origin of fibroblasts.
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Research from a leading international expert on the health of the Great Lakes suggests that the growing intensity and scale of pollution from plastics poses serious risks to human health and will continue to have profound consequences on the ecosystem.
In an article published this month in the Journal of Waste Resources and Recycling, Gail Krantzberg, a professor in the Booth School of Engineering Practice...
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