By using mouse models, the EU-funded DEPROHEALTH-project has demonstrated that some lactobacilli can have a beneficial effect on intestinal inflammation and infections. The major target disease in these mouse studies has been inflammation of the bowel. For this purpose, engineered lactobacilli were constructed. The modified strains that are most promising produce fair levels of an effective compound (an interleukine) that helps preventing the inflammation caused by bacteria. Four of the most promising candidate strains have been selected for future studies. These studies will test the effect of these strains in mice, in order to prepare future studies in humans.
Finding the effective bacteria has required a lot of background work. The research started with examining a number of wild strains of lactobacilli to find out about their potential capacity to interact with the host immune system. Ideally the beneficial bacteria should be taken orally, so their ability to survive passage trough the upper part of the intestinal tract is important and was indeed investigated. The acidic conditions in the stomach or the bile salts in the intestine may destroy their potential favourable influences.
DEPROHEALTH-project aims to design specific beneficial probiotic strains to avert intestinal illnesses. The project is developing new ways to tackle these illnesses by oral treatment which is much easier to administer than injections. Diseases targeted in the project are stomach ulcers linked with Helicobacter pylori, and infant diarrhoea, which is commonly caused by rotavirus. It also seeks to develop a new treatment against life long malign intestinal inflammation, such as Crohn’s disease, which severely affect the patient’s quality of life.
Dr. Annick Mercenier | Institut Pasteur de Lille
Scientists use nanoparticle-delivered gene therapy to inhibit blinding eye disease in rodents
08.07.2020 | Johns Hopkins Medicine
Deconstructing glioblastoma complexity reveals its pattern of development
08.07.2020 | McGill University
New insight into the spin behavior in an exotic state of matter puts us closer to next-generation spintronic devices
Aside from the deep understanding of the natural world that quantum physics theory offers, scientists worldwide are working tirelessly to bring forth a...
Kiel physics team observed extremely fast electronic changes in real time in a special material class
In physics, they are currently the subject of intensive research; in electronics, they could enable completely new functions. So-called topological materials...
Solar cells based on perovskite compounds could soon make electricity generation from sunlight even more efficient and cheaper. The laboratory efficiency of these perovskite solar cells already exceeds that of the well-known silicon solar cells. An international team led by Stefan Weber from the Max Planck Institute for Polymer Research (MPI-P) in Mainz has found microscopic structures in perovskite crystals that can guide the charge transport in the solar cell. Clever alignment of these "electron highways" could make perovskite solar cells even more powerful.
Solar cells convert sunlight into electricity. During this process, the electrons of the material inside the cell absorb the energy of the light....
Empa researchers have succeeded in applying aerogels to microelectronics: Aerogels based on cellulose nanofibers can effectively shield electromagnetic radiation over a wide frequency range – and they are unrivalled in terms of weight.
Electric motors and electronic devices generate electromagnetic fields that sometimes have to be shielded in order not to affect neighboring electronic...
A promising operating mode for the plasma of a future power plant has been developed at the ASDEX Upgrade fusion device at Max Planck Institute for Plasma...
07.07.2020 | Event News
02.07.2020 | Event News
19.05.2020 | Event News
10.07.2020 | Life Sciences
10.07.2020 | Materials Sciences
10.07.2020 | Life Sciences