Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Early diagnosis of childhood diabetes

16.01.2003


Diabetes is a chronic metabolic disorder that afflicts 17 million people in the United States and is the fourth leading cause of death. Over 2 million patients suffer from its most severe form - childhood diabetes – also known as Type 1, juvenile or insulin-dependent diabetes. We now understand that childhood diabetes is an autoimmune illness, where the body’s own white blood cells, which normally fight infection, turn and act against the body. These white blood cells target a specific group of cells in the pancreas – beta cells – that produce insulin, the hormone necessary to convert food into energy. Over time, such a large number of beta cells are destroyed that there is a lack of insulin and diabetes develops.



Scientists have long sought a means to predict the onset of diabetes through routine blood tests of destructive white blood cells so that high-risk individuals could be treated before all their beta cells are destroyed and they become diabetic. Progress has been so limited however, that it has been debated whether these cells were present in the blood at levels high enough to facilitate direct detection.

In the January 15 issue of the Journal of Clinical Investigation, Rusung Tan and colleagues at British Columbia’s Children’s Hospital, Canada, reveal a method for directly measuring the level of these self-destructive cells in the blood of mice and demonstrate that these levels reliably distinguish mice that go on to develop diabetes from those that do not.


Drs. George Eisenbarth and Brian Kotzin from the Barbara Davis Diabetes Center for Childhood Diabetes and the University of Colorado Health Sciences Center state in their accompanying commentary that "quantifying (these) cells in patients genetically at high risk to develop disease and in patients with prediabetes may be a more direct (and at least complementary) approach to detect beta cell autoimmunity and predict which patients will go on to develop disease". The researchers suggest that this technique may also be used to detect this group of self-destructive cells involved in other autoimmune disorders, thereby increasing our powers of predicting disease.


###
CONTACT:
Rusung Tan
Department of Pathology and Laboratory Medicine
British Columbia’s Children’s Hospital
4480 Oak Street
Vancouver
British Columbia
CANADA V6H 3V4
Phone: (604) 875-3605
Fax: (604) 875-3777
E-mail: roo@interchange.ubc.ca

View the PDF of this article at: https://www.the-jci.org/press/16409.pdf

ACCOMPANYING COMMENTARY: Enumerating autoreactive T cells in peripheral blood: a big step in diabetes prediction.

CONTACT:
George S. Eisenbarth
Barbara Davis Center for Childhood Diabetes
Box B140
4200 East Ninth Avenue
Denver, CO 80262
USA
Phone: (303) 315-4891
Fax: (303) 315-4892
E-mail: george.eisenbarth@uchsc.edu

View the PDF of this commentary at: https://www.the-jci.org/press/17621.pdf


Brooke Grindlinger, PhD | EurekAlert!
Further information:
http://www.jci.org/
http://www.the-jci.org/press/16409.
http://www.the-jci.org/press/17621.pdf

More articles from Health and Medicine:

nachricht Purdue cancer identity technology makes it easier to find a tumor's 'address'
16.11.2018 | Purdue University

nachricht Microgel powder fights infection and helps wounds heal
14.11.2018 | Michigan Technological University

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: UNH scientists help provide first-ever views of elusive energy explosion

Researchers at the University of New Hampshire have captured a difficult-to-view singular event involving "magnetic reconnection"--the process by which sparse particles and energy around Earth collide producing a quick but mighty explosion--in the Earth's magnetotail, the magnetic environment that trails behind the planet.

Magnetic reconnection has remained a bit of a mystery to scientists. They know it exists and have documented the effects that the energy explosions can...

Im Focus: A Chip with Blood Vessels

Biochips have been developed at TU Wien (Vienna), on which tissue can be produced and examined. This allows supplying the tissue with different substances in a very controlled way.

Cultivating human cells in the Petri dish is not a big challenge today. Producing artificial tissue, however, permeated by fine blood vessels, is a much more...

Im Focus: A Leap Into Quantum Technology

Faster and secure data communication: This is the goal of a new joint project involving physicists from the University of Würzburg. The German Federal Ministry of Education and Research funds the project with 14.8 million euro.

In our digital world data security and secure communication are becoming more and more important. Quantum communication is a promising approach to achieve...

Im Focus: Research icebreaker Polarstern begins the Antarctic season

What does it look like below the ice shelf of the calved massive iceberg A68?

On Saturday, 10 November 2018, the research icebreaker Polarstern will leave its homeport of Bremerhaven, bound for Cape Town, South Africa.

Im Focus: Penn engineers develop ultrathin, ultralight 'nanocardboard'

When choosing materials to make something, trade-offs need to be made between a host of properties, such as thickness, stiffness and weight. Depending on the application in question, finding just the right balance is the difference between success and failure

Now, a team of Penn Engineers has demonstrated a new material they call "nanocardboard," an ultrathin equivalent of corrugated paper cardboard. A square...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Optical Coherence Tomography: German-Japanese Research Alliance hosted Medical Imaging Conference

19.11.2018 | Event News

“3rd Conference on Laser Polishing – LaP 2018” Attracts International Experts and Users

09.11.2018 | Event News

On the brain’s ability to find the right direction

06.11.2018 | Event News

 
Latest News

New materials: Growing polymer pelts

19.11.2018 | Materials Sciences

Earthquake researchers finalists for supercomputing prize

19.11.2018 | Information Technology

Controlling organ growth with light

19.11.2018 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>