Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

T cell clones shrink melanoma tumors

13.11.2002


Paper published in the Proceeding of the National Academy of Sciences



Below is an advisory distributed today by the Proceedings of the National Academy of Sciences (PNAS). The paper can be found in the online early edition of PNAS at www.pnas.org.

The study, conducted by Dr. Cassian Yee, a researcher at the Fred Hutchinson Cancer Research Center, involved 10 people diagnosed with advanced melanoma. For each patient immune system cells able to identify and target melanoma were extracted and cloned. The cloned cells were expanded in the lab and re-injected into the patient. The results of the study showed that in five patients tumors stopped growing for up to one year and in three of the patients the tumors appeared to shrink.


"While we did not expect to cure the cancers, the technique appears to benefit patients by curbing the spread of their tumors, says Dr. Yee."

Soldier Clones: T Cells Target Tumors

A preliminary clinical trial suggests that armies of T cells generated in the lab can be injected into patients to halt the spread of cancerous tumors. One strategy for treating cancer is to sensitize the immune system to the presence of tumors so it can attack the cancerous cells. Vaccinating patients with proteins present on the cancerous cells could kick the immune system into action. Instead of relying on the immune system to manufacture a defense, however, Cassian Yee and colleagues tried supplying ready-made soldiers. In the lab, the authors grew T cells, those cells that destroy invaders or aberrant cells. To insure that the T cells found their target, the authors trained them on their quarry, stimulating the cells with a protein found on metastatic melanoma cells. The authors then injected these designer T cells into 10 patients over the course of 12 weeks. The results, reported in article #6000, indicate that the T cells clones were able to home in on the tumors, which regressed slightly or stabilized in 8 of the 10 patients, for an average period of 11 months. In addition to T cells, the injections contained IL-2, a chemical that stimulates the T cells to replicate, resupplying the troops. Although IL-2 can be toxic in high doses, the patients showed little reaction to the low dose of IL-2 used.


"Adoptive T cell therapy using antigen-specific CD8+ T cell clones for the treatment of patients with metastic melanoma: in vivo persistence, migration and anti-tumor effect of transferred T cells" by C. Yee, J.A. Thompson, D. Byrd, S.R. Riddell, P. Roche, E. Celis, P.D. Greenberg.

Susan Edmonds | EurekAlert!
Further information:
http://www.fhcrc.org/
http://www.pnas.org/

More articles from Health and Medicine:

nachricht Finding new clues to brain cancer treatment
21.02.2020 | Case Western Reserve University

nachricht UIC researchers find unique organ-specific signature profiles for blood vessel cells
18.02.2020 | University of Illinois at Chicago

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: A step towards controlling spin-dependent petahertz electronics by material defects

The operational speed of semiconductors in various electronic and optoelectronic devices is limited to several gigahertz (a billion oscillations per second). This constrains the upper limit of the operational speed of computing. Now researchers from the Max Planck Institute for the Structure and Dynamics of Matter in Hamburg, Germany, and the Indian Institute of Technology in Bombay have explained how these processes can be sped up through the use of light waves and defected solid materials.

Light waves perform several hundred trillion oscillations per second. Hence, it is natural to envision employing light oscillations to drive the electronic...

Im Focus: Freiburg researcher investigate the origins of surface texture

Most natural and artificial surfaces are rough: metals and even glasses that appear smooth to the naked eye can look like jagged mountain ranges under the microscope. There is currently no uniform theory about the origin of this roughness despite it being observed on all scales, from the atomic to the tectonic. Scientists suspect that the rough surface is formed by irreversible plastic deformation that occurs in many processes of mechanical machining of components such as milling.

Prof. Dr. Lars Pastewka from the Simulation group at the Department of Microsystems Engineering at the University of Freiburg and his team have simulated such...

Im Focus: Skyrmions like it hot: Spin structures are controllable even at high temperatures

Investigation of the temperature dependence of the skyrmion Hall effect reveals further insights into possible new data storage devices

The joint research project of Johannes Gutenberg University Mainz (JGU) and the Massachusetts Institute of Technology (MIT) that had previously demonstrated...

Im Focus: Making the internet more energy efficient through systemic optimization

Researchers at Chalmers University of Technology, Sweden, recently completed a 5-year research project looking at how to make fibre optic communications systems more energy efficient. Among their proposals are smart, error-correcting data chip circuits, which they refined to be 10 times less energy consumptive. The project has yielded several scientific articles, in publications including Nature Communications.

Streaming films and music, scrolling through social media, and using cloud-based storage services are everyday activities now.

Im Focus: New synthesis methods enhance 3D chemical space for drug discovery

After helping develop a new approach for organic synthesis -- carbon-hydrogen functionalization -- scientists at Emory University are now showing how this approach may apply to drug discovery. Nature Catalysis published their most recent work -- a streamlined process for making a three-dimensional scaffold of keen interest to the pharmaceutical industry.

"Our tools open up whole new chemical space for potential drug targets," says Huw Davies, Emory professor of organic chemistry and senior author of the paper.

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

70th Lindau Nobel Laureate Meeting: Around 70 Laureates set to meet with young scientists from approx. 100 countries

12.02.2020 | Event News

11th Advanced Battery Power Conference, March 24-25, 2020 in Münster/Germany

16.01.2020 | Event News

Laser Colloquium Hydrogen LKH2: fast and reliable fuel cell manufacturing

15.01.2020 | Event News

 
Latest News

Active droplets

21.02.2020 | Medical Engineering

Finding new clues to brain cancer treatment

21.02.2020 | Health and Medicine

Beyond the brim, Sombrero Galaxy's halo suggests turbulent past

21.02.2020 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>