Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Model for common type of cancer developed by UCLA scientists

30.10.2002


Scientists at UCLA’s Jonsson Cancer Center have developed the world’s first animal model for mature human B-cell lymphomas, a discovery that may lead to the uncovering of the genetic mutations that cause these types of cancer. Mature B-cell type lymphomas account for about 85 percent of all lymphomas.



The basic science discovery is outlined in the Oct. 29 issue of the peer-reviewed journal Proceedings of the National Academy of Sciences.

"What we can do now is grow cell lines out of this model to determine which cancer-causing companion mutations arise," said Dr. Mike Teitell, a physician and researcher at UCLA’s Jonsson Cancer Center and the lead author of the article, available online at www.pnas.org/. "This model appears to yield a large spectrum of mature B-cell lymphomas."


Teitell, collaborator Randolph Wall, and their research team, scientist Katrina Hoyer and Dr. Samuel French, had previously identified an abnormality in a gene called T-cell leukemia 1 (TCL1) in patients with B-cell lymphomas, especially in those suffering from AIDS.

The researchers wondered what would happen if they developed an animal model with abnormally expressed TCL1 -- would the model develop cancer? Teitell and his team got more than they expected: animals with abnormally regulated TCL1 developed three different types of lymphoma.

"This finding suggested that specific mutations in addition to TCL1 were causing distinct types of B-cell malignancy. It was a very surprising result," Teitell said "Before this, we did not have a model for any of these forms of lymphoma. Since we can now generate all these different types, we are in a position to understand the changes that cause each type. For example, why does one animal with abnormal TCL1 expression develop one type of lymphoma, while a genetically identical animal develops a different type?"

B-cell lymphomas include both Hodgkin’s and non-Hodgkin’s lymphomas. Specifically, the three types of B-cell lymphoma that grew out of Teitell’s animal model were Burkitt-like lymphoma, diffuse large B-cell lymphoma and follicular center cell lymphoma, all of which are classified as non-Hodgkin’s lymphomas.

Now the team wants to know why these three forms arose in the same genetic background. Teitell theorizes that there may be different cell pathways -- or highways that cells use to send signals -- involved in the three different types of lymphoma. If Teitell and his team can identify the pathways, they can attempt to block them with new drugs, Teitell said, akin to hitting the brake on a car or turning off a light switch. The idea is to interrupt the cell signal before it triggers the genetic mutation that causes the cancer to begin to grow.

"I think we may have identified an important mechanism that links certain signaling pathways with the causation of certain cancers, in this case in the immune system but perhaps in other parts of the body as well," Teitell said.

Lymphomas are cancers that start in lymphoid tissue, also called lymphatic tissue. The lymphatic system is important for filtering germs and cancer cells, as well as fluid from the extremities and internal organs. Lymphoid tissue is found in many places throughout the body, including lymph nodes, the thymus, the spleen, the tonsils and adenoids, in the bone marrow, and scattered within other systems, such as the digestive and respiratory systems.

About 60,000 Americans will develop lymphomas, and 26,000 people will die of the disease this year alone, according to the American Cancer Society.

The next step for Teitell and his research team will be to develop molecules that block the action of TCL1, trying to discover what cell pathway or pathways are being used by cells destined to become malignant. They also are working to discover if TCL1 is abnormally expressed in other human cancers.

"I think this has real promise," Teitell said. "This has a chance to go all the way."

Kim Irwin | EurekAlert!

More articles from Health and Medicine:

nachricht The genes are not to blame
20.07.2018 | Technische Universität München

nachricht Targeting headaches and tumors with nano-submarines
20.07.2018 | Universitätsmedizin der Johannes Gutenberg-Universität Mainz

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Future electronic components to be printed like newspapers

A new manufacturing technique uses a process similar to newspaper printing to form smoother and more flexible metals for making ultrafast electronic devices.

The low-cost process, developed by Purdue University researchers, combines tools already used in industry for manufacturing metals on a large scale, but uses...

Im Focus: First evidence on the source of extragalactic particles

For the first time ever, scientists have determined the cosmic origin of highest-energy neutrinos. A research group led by IceCube scientist Elisa Resconi, spokesperson of the Collaborative Research Center SFB1258 at the Technical University of Munich (TUM), provides an important piece of evidence that the particles detected by the IceCube neutrino telescope at the South Pole originate from a galaxy four billion light-years away from Earth.

To rule out other origins with certainty, the team led by neutrino physicist Elisa Resconi from the Technical University of Munich and multi-wavelength...

Im Focus: Magnetic vortices: Two independent magnetic skyrmion phases discovered in a single material

For the first time a team of researchers have discovered two different phases of magnetic skyrmions in a single material. Physicists of the Technical Universities of Munich and Dresden and the University of Cologne can now better study and understand the properties of these magnetic structures, which are important for both basic research and applications.

Whirlpools are an everyday experience in a bath tub: When the water is drained a circular vortex is formed. Typically, such whirls are rather stable. Similar...

Im Focus: Breaking the bond: To take part or not?

Physicists working with Roland Wester at the University of Innsbruck have investigated if and how chemical reactions can be influenced by targeted vibrational excitation of the reactants. They were able to demonstrate that excitation with a laser beam does not affect the efficiency of a chemical exchange reaction and that the excited molecular group acts only as a spectator in the reaction.

A frequently used reaction in organic chemistry is nucleophilic substitution. It plays, for example, an important role in in the synthesis of new chemical...

Im Focus: New 2D Spectroscopy Methods

Optical spectroscopy allows investigating the energy structure and dynamic properties of complex quantum systems. Researchers from the University of Würzburg present two new approaches of coherent two-dimensional spectroscopy.

"Put an excitation into the system and observe how it evolves." According to physicist Professor Tobias Brixner, this is the credo of optical spectroscopy....

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Leading experts in Diabetes, Metabolism and Biomedical Engineering discuss Precision Medicine

13.07.2018 | Event News

Conference on Laser Polishing – LaP: Fine Tuning for Surfaces

12.07.2018 | Event News

11th European Wood-based Panel Symposium 2018: Meeting point for the wood-based materials industry

03.07.2018 | Event News

 
Latest News

A smart safe rechargeable zinc ion battery based on sol-gel transition electrolytes

20.07.2018 | Power and Electrical Engineering

Reversing cause and effect is no trouble for quantum computers

20.07.2018 | Information Technology

Princeton-UPenn research team finds physics treasure hidden in a wallpaper pattern

20.07.2018 | Materials Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>