Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Researchers track elusive brain tumor cells in mice with neural stem cells modified to deliver IL-12

15.10.2002


Findings are cover story of Oct. 15 issue of Cancer Research



Researchers at Cedars-Sinai Medical Center’s Maxine Dunitz Neurosurgical Institute have successfully tested a new treatment for brain cancer by utilizing neural stem cells to track and destroy cancer cells within the brain. Scientists hope the encouraging results may eventually lead to an effective treatment for glioma, the most aggressive form of primary brain tumor in humans. The study, conducted in mice with experimental brain cancer, is featured on the cover of the Oct. 15 issue of the journal Cancer Research.

The prognosis has historically been extremely poor for patients diagnosed with malignant gliomas. These tumors have very poorly defined margins, and glioma cells often spread deep into healthy brain tissue making their effective surgical removal extremely difficult. Often, pockets of tumor cells break off from the main tumor and migrate deep into non-tumorous areas of the brain. Therefore, even if the original tumor is completely removed or destroyed, the risk of recurrence is high as cells in these distant "satellites" multiply and eventually re-form a new brain tumor. Due to these characteristics, treating brain cancer has been extremely difficult.


The new experimental treatment involves the use of neural stem cells for tracking and targeting brain tumor cells that spread out into normal brain. Scientists show that neural stem cells, when injected into brain tumors, can follow tumor cells as they migrate away from the main tumor mass. This capability led scientists to genetically engineer neural stem cells to produce interleukin 12, an immune stimulating chemical known to kill glioma cells. The interleukin 12 producing neural stem cells were then injected into brain tumors in mice and could kill tumor cells that had spread deep into normal brain tissue, at considerable distance from the primary tumor. Mice treated with this novel strategy survived significantly longer than control-treated mice. In fact, 30% of animals treated in this new manner developed long-term immunity to brain cancer, indicating the potency of this therapy.

Scientists demonstrated that the neural stem cells were able to kill the spreading tumor cells by delivering interleukin 12 directly to these migrating glioma "satellites". Previous research at the Maxine Dunitz Neurosurgical Institute has demonstrated that interleukin 12 can activate cancer killing cells from the immune system to attack and destroy brain tumor cells. The ability of neural stem cells to deliver this immune stimulating protein directly to small pockets of brain tumor cells that can not be accessed using surgery, represents a promising new method that could be used to eliminate all remaining tumor left behind after routine surgery. This could hopefully lower the incidence of tumor recurrence and improve survival in patients with malignant gliomas.

"The current focus of experimental neural stem cell therapeutics is primarily based around their use in the treatment of neurodegenerative disorders and stroke. We have demonstrated that combining the tumoricidal potency of interleukin 12 with the extensive tumor tracing capability of neural stem cells, results in a synergistic therapeutic benefit," according to the authors. "This further extends the scope of neural stem cell therapy to include their use as vehicles for protein delivery to in vivo glioma, and therefore represents a promising new treatment modality for malignant brain tumors."

Sandra Van | EurekAlert!
Further information:
http://www.csmc.edu/

More articles from Health and Medicine:

nachricht The genes are not to blame
20.07.2018 | Technische Universität München

nachricht Targeting headaches and tumors with nano-submarines
20.07.2018 | Universitätsmedizin der Johannes Gutenberg-Universität Mainz

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Future electronic components to be printed like newspapers

A new manufacturing technique uses a process similar to newspaper printing to form smoother and more flexible metals for making ultrafast electronic devices.

The low-cost process, developed by Purdue University researchers, combines tools already used in industry for manufacturing metals on a large scale, but uses...

Im Focus: First evidence on the source of extragalactic particles

For the first time ever, scientists have determined the cosmic origin of highest-energy neutrinos. A research group led by IceCube scientist Elisa Resconi, spokesperson of the Collaborative Research Center SFB1258 at the Technical University of Munich (TUM), provides an important piece of evidence that the particles detected by the IceCube neutrino telescope at the South Pole originate from a galaxy four billion light-years away from Earth.

To rule out other origins with certainty, the team led by neutrino physicist Elisa Resconi from the Technical University of Munich and multi-wavelength...

Im Focus: Magnetic vortices: Two independent magnetic skyrmion phases discovered in a single material

For the first time a team of researchers have discovered two different phases of magnetic skyrmions in a single material. Physicists of the Technical Universities of Munich and Dresden and the University of Cologne can now better study and understand the properties of these magnetic structures, which are important for both basic research and applications.

Whirlpools are an everyday experience in a bath tub: When the water is drained a circular vortex is formed. Typically, such whirls are rather stable. Similar...

Im Focus: Breaking the bond: To take part or not?

Physicists working with Roland Wester at the University of Innsbruck have investigated if and how chemical reactions can be influenced by targeted vibrational excitation of the reactants. They were able to demonstrate that excitation with a laser beam does not affect the efficiency of a chemical exchange reaction and that the excited molecular group acts only as a spectator in the reaction.

A frequently used reaction in organic chemistry is nucleophilic substitution. It plays, for example, an important role in in the synthesis of new chemical...

Im Focus: New 2D Spectroscopy Methods

Optical spectroscopy allows investigating the energy structure and dynamic properties of complex quantum systems. Researchers from the University of Würzburg present two new approaches of coherent two-dimensional spectroscopy.

"Put an excitation into the system and observe how it evolves." According to physicist Professor Tobias Brixner, this is the credo of optical spectroscopy....

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Leading experts in Diabetes, Metabolism and Biomedical Engineering discuss Precision Medicine

13.07.2018 | Event News

Conference on Laser Polishing – LaP: Fine Tuning for Surfaces

12.07.2018 | Event News

11th European Wood-based Panel Symposium 2018: Meeting point for the wood-based materials industry

03.07.2018 | Event News

 
Latest News

A smart safe rechargeable zinc ion battery based on sol-gel transition electrolytes

20.07.2018 | Power and Electrical Engineering

Reversing cause and effect is no trouble for quantum computers

20.07.2018 | Information Technology

Princeton-UPenn research team finds physics treasure hidden in a wallpaper pattern

20.07.2018 | Materials Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>