Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New breast cancer gene discovered

08.10.2002


DBC2 gene missing or inactive in 60% of breast cancers examined



Scientists at Cold Spring Harbor Laboratory and the University of Washington have discovered a new tumor suppressor gene that is missing or inactive in as many as 60% of breast cancers, and is also altered in lung cancer.

The discovery of the gene, called DBC2 (for deleted in breast cancer) is highly significant because DBC2 is among the first tumor suppressor genes to be clearly associated with sporadic breast cancer. Sporadic disease accounts for greater than 90% of all forms of breast and other cancers, in contrast to heritable forms of cancer, which account for a relatively small percentage of the disease.


Importantly, the researchers showed that production of the Dbc2 protein in breast cancer cells kills the cancer cells or stops them from growing.

The study - to be published on October 15 in the Proceedings of the National Academy of Sciences - will be published on-line (at PNAS Early Edition, http://www.pnas.org/papbyrecent.shtml) during the week of October 7. The media embargo will lift at 5:00 PM EST on Monday, October 7.

In 1997, the same research group at Cold Spring Harbor Laboratory, led by Dr. Michael Wigler, identified one of the only other tumor suppressor genes (called PTEN) to be clearly associated with sporadic cancer. In 1981, Dr. Wigler’s group discovered the first cancer-causing oncogene, called RAS, from human cells.

In 1990, the same research group at the University of Washington, led by Dr. Mary-Claire King, discovered the first gene linked to hereditary breast cancer, called BRCA1.


For more information, a comprehensive press release, a copy of the study, or to arrange interviews with Dr. Wigler or Dr. King, please contact Peter Sherwood, Chief Science Correspondent, Cold Spring Harbor Laboratory (tel: 516-367-6947; e-mail: sherwood@cshl.edu).


Peter Sherwood | EurekAlert!
Further information:
http://www.cshl.org/
http://www.pnas.org/papbyrecent.shtml

More articles from Health and Medicine:

nachricht Correct antibiotic dosing could preserve lung microbial diversity in cystic fibrosis
22.02.2019 | Children's National Health System

nachricht Researchers find trigger that turns strep infections into flesh-eating disease
19.02.2019 | Houston Methodist

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: (Re)solving the jet/cocoon riddle of a gravitational wave event

An international research team including astronomers from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has combined radio telescopes from five continents to prove the existence of a narrow stream of material, a so-called jet, emerging from the only gravitational wave event involving two neutron stars observed so far. With its high sensitivity and excellent performance, the 100-m radio telescope in Effelsberg played an important role in the observations.

In August 2017, two neutron stars were observed colliding, producing gravitational waves that were detected by the American LIGO and European Virgo detectors....

Im Focus: Light from a roll – hybrid OLED creates innovative and functional luminous surfaces

Up to now, OLEDs have been used exclusively as a novel lighting technology for use in luminaires and lamps. However, flexible organic technology can offer much more: as an active lighting surface, it can be combined with a wide variety of materials, not just to modify but to revolutionize the functionality and design of countless existing products. To exemplify this, the Fraunhofer FEP together with the company EMDE development of light GmbH will be presenting hybrid flexible OLEDs integrated into textile designs within the EU-funded project PI-SCALE for the first time at LOPEC (March 19-21, 2019 in Munich, Germany) as examples of some of the many possible applications.

The Fraunhofer FEP, a provider of research and development services in the field of organic electronics, has long been involved in the development of...

Im Focus: Regensburg physicists watch electron transfer in a single molecule

For the first time, an international team of scientists based in Regensburg, Germany, has recorded the orbitals of single molecules in different charge states in a novel type of microscopy. The research findings are published under the title “Mapping orbital changes upon electron transfer with tunneling microscopy on insulators” in the prestigious journal “Nature”.

The building blocks of matter surrounding us are atoms and molecules. The properties of that matter, however, are often not set by these building blocks...

Im Focus: University of Konstanz gains new insights into the recent development of the human immune system

Scientists at the University of Konstanz identify fierce competition between the human immune system and bacterial pathogens

Cell biologists from the University of Konstanz shed light on a recent evolutionary process in the human immune system and publish their findings in the...

Im Focus: Transformation through Light

Laser physicists have taken snapshots of carbon molecules C₆₀ showing how they transform in intense infrared light

When carbon molecules C₆₀ are exposed to an intense infrared light, they change their ball-like structure to a more elongated version. This has now been...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Global Legal Hackathon at HAW Hamburg

11.02.2019 | Event News

The world of quantum chemistry meets in Heidelberg

30.01.2019 | Event News

Our digital society in 2040

16.01.2019 | Event News

 
Latest News

JILA researchers make coldest quantum gas of molecules

22.02.2019 | Physics and Astronomy

Understanding high efficiency of deep ultraviolet LEDs

22.02.2019 | Materials Sciences

Russian scientists show changes in the erythrocyte nanostructure under stress

22.02.2019 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>