Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New breast cancer gene discovered

08.10.2002


DBC2 gene missing or inactive in 60% of breast cancers examined



Scientists at Cold Spring Harbor Laboratory and the University of Washington have discovered a new tumor suppressor gene that is missing or inactive in as many as 60% of breast cancers, and is also altered in lung cancer.

The discovery of the gene, called DBC2 (for deleted in breast cancer) is highly significant because DBC2 is among the first tumor suppressor genes to be clearly associated with sporadic breast cancer. Sporadic disease accounts for greater than 90% of all forms of breast and other cancers, in contrast to heritable forms of cancer, which account for a relatively small percentage of the disease.


Importantly, the researchers showed that production of the Dbc2 protein in breast cancer cells kills the cancer cells or stops them from growing.

The study - to be published on October 15 in the Proceedings of the National Academy of Sciences - will be published on-line (at PNAS Early Edition, http://www.pnas.org/papbyrecent.shtml) during the week of October 7. The media embargo will lift at 5:00 PM EST on Monday, October 7.

In 1997, the same research group at Cold Spring Harbor Laboratory, led by Dr. Michael Wigler, identified one of the only other tumor suppressor genes (called PTEN) to be clearly associated with sporadic cancer. In 1981, Dr. Wigler’s group discovered the first cancer-causing oncogene, called RAS, from human cells.

In 1990, the same research group at the University of Washington, led by Dr. Mary-Claire King, discovered the first gene linked to hereditary breast cancer, called BRCA1.


For more information, a comprehensive press release, a copy of the study, or to arrange interviews with Dr. Wigler or Dr. King, please contact Peter Sherwood, Chief Science Correspondent, Cold Spring Harbor Laboratory (tel: 516-367-6947; e-mail: sherwood@cshl.edu).


Peter Sherwood | EurekAlert!
Further information:
http://www.cshl.org/
http://www.pnas.org/papbyrecent.shtml

More articles from Health and Medicine:

nachricht Neutrons produce first direct 3D maps of water during cell membrane fusion
21.09.2018 | DOE/Oak Ridge National Laboratory

nachricht Narcolepsy, scientists unmask the culprit of an enigmatic disease
20.09.2018 | Universitätsspital Bern

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Scientists present new observations to understand the phase transition in quantum chromodynamics

The building blocks of matter in our universe were formed in the first 10 microseconds of its existence, according to the currently accepted scientific picture. After the Big Bang about 13.7 billion years ago, matter consisted mainly of quarks and gluons, two types of elementary particles whose interactions are governed by quantum chromodynamics (QCD), the theory of strong interaction. In the early universe, these particles moved (nearly) freely in a quark-gluon plasma.

This is a joint press release of University Muenster and Heidelberg as well as the GSI Helmholtzzentrum für Schwerionenforschung in Darmstadt.

Then, in a phase transition, they combined and formed hadrons, among them the building blocks of atomic nuclei, protons and neutrons. In the current issue of...

Im Focus: Patented nanostructure for solar cells: Rough optics, smooth surface

Thin-film solar cells made of crystalline silicon are inexpensive and achieve efficiencies of a good 14 percent. However, they could do even better if their shiny surfaces reflected less light. A team led by Prof. Christiane Becker from the Helmholtz-Zentrum Berlin (HZB) has now patented a sophisticated new solution to this problem.

"It is not enough simply to bring more light into the cell," says Christiane Becker. Such surface structures can even ultimately reduce the efficiency by...

Im Focus: New soft coral species discovered in Panama

A study in the journal Bulletin of Marine Science describes a new, blood-red species of octocoral found in Panama. The species in the genus Thesea was discovered in the threatened low-light reef environment on Hannibal Bank, 60 kilometers off mainland Pacific Panama, by researchers at the Smithsonian Tropical Research Institute in Panama (STRI) and the Centro de Investigación en Ciencias del Mar y Limnología (CIMAR) at the University of Costa Rica.

Scientists established the new species, Thesea dalioi, by comparing its physical traits, such as branch thickness and the bright red colony color, with the...

Im Focus: New devices based on rust could reduce excess heat in computers

Physicists explore long-distance information transmission in antiferromagnetic iron oxide

Scientists have succeeded in observing the first long-distance transfer of information in a magnetic group of materials known as antiferromagnets.

Im Focus: Finding Nemo's genes

An international team of researchers has mapped Nemo's genome

An international team of researchers has mapped Nemo's genome, providing the research community with an invaluable resource to decode the response of fish to...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

One of the world’s most prominent strategic forums for global health held in Berlin in October 2018

03.09.2018 | Event News

4th Intelligent Materials - European Symposium on Intelligent Materials

27.08.2018 | Event News

LaserForum 2018 deals with 3D production of components

17.08.2018 | Event News

 
Latest News

Fraunhofer ISE with over 60 Contributions at the European PV Solar Energy Conference and Exhibition

21.09.2018 | Trade Fair News

558 million-year-old fat reveals earliest known animal

21.09.2018 | Earth Sciences

Neutrons produce first direct 3D maps of water during cell membrane fusion

21.09.2018 | Health and Medicine

VideoLinks
Science & Research
Overview of more VideoLinks >>>