Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Novel form of vitamin D shown to grow bone

01.10.2002


A novel form of vitamin D has been shown to grow bone in the lab and in experimental animals, a result that holds promise for the estimated 44 million Americans, mostly post-menopausal women, who suffer from or are at risk for the bone-wasting disease osteoporosis.



The research, conducted by a team of scientists led by biochemist Hector F. DeLuca at the University of Wisconsin-Madison, was reported this week (Sept. 30) in the Proceedings of the National Academy of Sciences (PNAS), a leading scientific journal.

"We’ve got a compound that is very selective for bone," says DeLuca. "It is very effective in animals," increasing bone density significantly in rats with a condition that mimics human osteoporosis, and can be used in the lab to grow bone in culture.


The research, conducted by DeLuca, Nirupama K. Shevde, Lori A. Plum, Margaret Claggett-Dame, Hironori Yamamoto and J. Wesley Pike, describes the effects of a potent Vitamin D analog known in scientific shorthand as 2MD. Its synthesis by the Wisconsin group, and studies of its effects in the lab and in animals, suggests the potential for developing a class of drugs that could effectively reverse bone loss in humans suffering from osteoporosis, a disease characterized by diminished bone density and, ultimately, brittle, fracture-prone bones.

"From where I sit, this is the most promising vitamin D compound I’ve seen," says DeLuca, an international authority on vitamin D and its chemistry.

But he stressed that while the new compound posts astonishing results when used in experimental animals, it has yet to be tested in humans and it will likely be several years at best before a drug reaches the market.

"There’s nothing like it on the market now. We think it could become a major actor, but we haven’t done any experiments in people," he says.

The compound could become an important alternative to hormone replacement therapy, one of whose benefits was prevention of bone loss in post-menopausal women. Because of new evidence of an increased risk of cancer, hormone replacement therapy has recently been called into question.

The vitamin D analog developed by the Wisconsin team was tested in rats that had their ovaries removed to mimic menopause and the bone wasting associated with osteoporosis. Rats given the new vitamin D analog exhibited a 9 percent increase in total body bone mass. Importantly, vertebrae in the treated rats exhibited a 25 percent increase in bone mass. Frequently, osteoporosis patients exhibit a stooped posture as the bones in the spinal column tend to be among the most affected by osteoporosis.

The compound also added bone mass to the long bones in the limbs of animals used in the study.

According to DeLuca, the 2MD compound is also the first vitamin D analog shown to increase bone mass, and that exhibits no apparent toxicity or side effects.

2MD acts at very low concentrations and appears to work by promoting the growth of osteoblasts, the cells responsible for making bone. Another form of vitamin D is now used to treat osteoporosis, but its bone-building action is limited.

"Our results suggest that 2MD exhibits at very low concentrations a marked and unexpected activity in stimulating the synthesis of new bone," the Wisconsin team wrote in their PNAS report. "This activity is at best only weakly observed with (the other active form of vitamin D) and then only at very high concentrations."

It is possible, the authors suggest, that 2MD possesses a "unique capacity to induce genes capable of orchestrating the process leading to the formation of bone nodules."


Terry Devitt (608) 262-8282, trdevitt@facstaff.wisc.edu;
Emily Carlson (608) 262-9772, emilycarlson@facstaff

Hector F. DeLuca | EurekAlert!
Further information:
http://www.news.wisc.edu/newsphotos/deluca.html

More articles from Health and Medicine:

nachricht Clear vision – project for safer laser treatment of floaters started
26.05.2020 | Laser Zentrum Hannover e.V.

nachricht Researchers develop high-performance cancer vaccine using novel microcapsules
25.05.2020 | Chinese Academy of Sciences Headquarters

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: New double-contrast technique picks up small tumors on MRI

Early detection of tumors is extremely important in treating cancer. A new technique developed by researchers at the University of California, Davis offers a significant advance in using magnetic resonance imaging to pick out even very small tumors from normal tissue. The work is published May 25 in the journal Nature Nanotechnology.

researchers at the University of California, Davis offers a significant advance in using magnetic resonance imaging to pick out even very small tumors from...

Im Focus: I-call - When microimplants communicate with each other / Innovation driver digitization - "Smart Health“

Microelectronics as a key technology enables numerous innovations in the field of intelligent medical technology. The Fraunhofer Institute for Biomedical Engineering IBMT coordinates the BMBF cooperative project "I-call" realizing the first electronic system for ultrasound-based, safe and interference-resistant data transmission between implants in the human body.

When microelectronic systems are used for medical applications, they have to meet high requirements in terms of biocompatibility, reliability, energy...

Im Focus: When predictions of theoretical chemists become reality

Thomas Heine, Professor of Theoretical Chemistry at TU Dresden, together with his team, first predicted a topological 2D polymer in 2019. Only one year later, an international team led by Italian researchers was able to synthesize these materials and experimentally prove their topological properties. For the renowned journal Nature Materials, this was the occasion to invite Thomas Heine to a News and Views article, which was published this week. Under the title "Making 2D Topological Polymers a reality" Prof. Heine describes how his theory became a reality.

Ultrathin materials are extremely interesting as building blocks for next generation nano electronic devices, as it is much easier to make circuits and other...

Im Focus: Rolling into the deep

Scientists took a leukocyte as the blueprint and developed a microrobot that has the size, shape and moving capabilities of a white blood cell. Simulating a blood vessel in a laboratory setting, they succeeded in magnetically navigating the ball-shaped microroller through this dynamic and dense environment. The drug-delivery vehicle withstood the simulated blood flow, pushing the developments in targeted drug delivery a step further: inside the body, there is no better access route to all tissues and organs than the circulatory system. A robot that could actually travel through this finely woven web would revolutionize the minimally-invasive treatment of illnesses.

A team of scientists from the Max Planck Institute for Intelligent Systems (MPI-IS) in Stuttgart invented a tiny microrobot that resembles a white blood cell...

Im Focus: NASA's Curiosity rover finds clues to chilly ancient Mars buried in rocks

By studying the chemical elements on Mars today -- including carbon and oxygen -- scientists can work backwards to piece together the history of a planet that once had the conditions necessary to support life.

Weaving this story, element by element, from roughly 140 million miles (225 million kilometers) away is a painstaking process. But scientists aren't the type...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Dresden Nexus Conference 2020: Same Time, Virtual Format, Registration Opened

19.05.2020 | Event News

Aachen Machine Tool Colloquium AWK'21 will take place on June 10 and 11, 2021

07.04.2020 | Event News

International Coral Reef Symposium in Bremen Postponed by a Year

06.04.2020 | Event News

 
Latest News

NIST researchers boost microwave signal stability a hundredfold

26.05.2020 | Physics and Astronomy

Complex genetic regulation of flowering time

26.05.2020 | Life Sciences

'One-way' electronic devices enter the mainstream

26.05.2020 | Information Technology

VideoLinks
Science & Research
Overview of more VideoLinks >>>