Research at Oregon Health & Science University (OHSU) has revealed that certain chemical ingredients of gasoline, jet fuel and other solvents may pose a greater health hazard than first thought. Scientists at the OHSU Center for Research on Occupational and Environmental Toxicology (CROET) have shown that a benzene derivative damages the nervous system. In fact, the substance is much more active than non-benzene analogs already known to cause peripheral nerve damage (loss of limb sensation and muscle weakness) in solvent-exposed workers. The research team was led by Mohammad Sabri, Ph.D., and Peter Spencer, Ph.D., F.R.C. Path., of OHSU. The conclusions of the research are printed in the September 2002 issue of the Journal of Toxicology and Applied Pharmacology.
"Previously, researchers believed that benzene derivatives were unable to damage the nervous system," said Spencer. "The substance we studied - 1,2-diacetylbenzene - has a ring-like (aromatic) chemical structure in contrast to the straight-chain (aliphatic) solvents that are well established causes of occupation-related nerve damage. Our data suggest the aromatic substance actually has a much higher neurotoxic potency. In addition, the new findings raise the possibility that related aromatic chemicals may also damage the nervous system. We believe these substances should be tested for neurotoxicity, and occupational exposures should be regulated to prevent illness among workers who come in contact with these chemicals."
One of these related aromatic chemicals, a substance known as Musk tetralin, was used until the 1980s by the fragrance industry to hide product odor in soaps and fragrances. The industry voluntarily withdrew Musk tetralin worldwide after Spencer and fellow researchers demonstrated the substance was neurotoxic. Because aromatic hydrocarbons have been used in such large quantities by the public and in commerce, the chemicals are now common soil and water contaminants.
Jim Newman | EurekAlert!
Live probiotics can re-balance the gut microbiome and modify immune system response
20.11.2018 | Symprove
Purdue cancer identity technology makes it easier to find a tumor's 'address'
16.11.2018 | Purdue University
Max Planck researchers revel the nano-structure of molecular trains and the reason for smooth transport in cellular antennas.
Moving around, sensing the extracellular environment, and signaling to other cells are important for a cell to function properly. Responsible for those tasks...
Researchers at the University of New Hampshire have captured a difficult-to-view singular event involving "magnetic reconnection"--the process by which sparse particles and energy around Earth collide producing a quick but mighty explosion--in the Earth's magnetotail, the magnetic environment that trails behind the planet.
Magnetic reconnection has remained a bit of a mystery to scientists. They know it exists and have documented the effects that the energy explosions can...
Biochips have been developed at TU Wien (Vienna), on which tissue can be produced and examined. This allows supplying the tissue with different substances in a very controlled way.
Cultivating human cells in the Petri dish is not a big challenge today. Producing artificial tissue, however, permeated by fine blood vessels, is a much more...
Faster and secure data communication: This is the goal of a new joint project involving physicists from the University of Würzburg. The German Federal Ministry of Education and Research funds the project with 14.8 million euro.
In our digital world data security and secure communication are becoming more and more important. Quantum communication is a promising approach to achieve...
On Saturday, 10 November 2018, the research icebreaker Polarstern will leave its homeport of Bremerhaven, bound for Cape Town, South Africa.
19.11.2018 | Event News
09.11.2018 | Event News
06.11.2018 | Event News
20.11.2018 | Life Sciences
20.11.2018 | Life Sciences
20.11.2018 | Physics and Astronomy