The inflammatory myopathies comprise three different entities: polymyositis, inclusion body myositis and dermatomyositis. People in all age groups can be affected by major muscle weakness and pain, and show evidence of muscle fiber breakdown in the serum. Autoimmune pathogenetic mechanisms have been identified in each inflammatory myopathy, but the antigen(s) recognized by the autoreactive inflammatory cells and the factors eliciting the aberrant immune responses remain unknown. Currently, patients are treated with corticosteroids with variable success rates and at a high cost of side-effects.
The ongoing research is aimed at identifying the factors that guide the trafficking of inflammatory cells from the blood to the inflamed muscle tissue. A new study reports the differential expression of chemokines and their receptors in each inflammatory myopathy. Chemokines represent a family of small-molecular weight cytokines that have an important role in the migration of distinct leukocyte subsets to the sites of inflammation. The chemokines monocyte chemoattractant protein-1 (MCP-1) and stromal derived factor (SDF-1a and SDF-1b) and their receptors are strongly expressed whereas a number of others are undetectable.
Blocking the autoimmune cascade by targeting chemokines or chemokine receptors has given excellent results in animal models of other immune diseases. The present work identifies the candidates for selective immune intervention in patients suffering autoimmune inflammatory myopathies and may well lead to more selective treatment modalities with less side-effects than the currently available drugs.
Jan DE BLEECKER | alfa
Purdue cancer identity technology makes it easier to find a tumor's 'address'
16.11.2018 | Purdue University
Microgel powder fights infection and helps wounds heal
14.11.2018 | Michigan Technological University
Researchers at the University of New Hampshire have captured a difficult-to-view singular event involving "magnetic reconnection"--the process by which sparse particles and energy around Earth collide producing a quick but mighty explosion--in the Earth's magnetotail, the magnetic environment that trails behind the planet.
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Biochips have been developed at TU Wien (Vienna), on which tissue can be produced and examined. This allows supplying the tissue with different substances in a very controlled way.
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Faster and secure data communication: This is the goal of a new joint project involving physicists from the University of Würzburg. The German Federal Ministry of Education and Research funds the project with 14.8 million euro.
In our digital world data security and secure communication are becoming more and more important. Quantum communication is a promising approach to achieve...
On Saturday, 10 November 2018, the research icebreaker Polarstern will leave its homeport of Bremerhaven, bound for Cape Town, South Africa.
When choosing materials to make something, trade-offs need to be made between a host of properties, such as thickness, stiffness and weight. Depending on the application in question, finding just the right balance is the difference between success and failure
Now, a team of Penn Engineers has demonstrated a new material they call "nanocardboard," an ultrathin equivalent of corrugated paper cardboard. A square...
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16.11.2018 | Life Sciences