A skin test can detect a tissue disorder that may increase the risk of intracranial aneurysm, which can lead to stroke, according to a pilot study published in the September Stroke: Journal of the American Heart Association. Researchers found defects in the structural matrix of skin tissue in 33 percent of study patients with intracranial aneurysms.
Aneurysms are weakened sections of blood vessels that balloon out from the artery wall. When they rupture, they can cause a type of stroke known as subarachnoid hemorrhage – bleeding in the brain.
"Our findings suggest that people with multiple aneurysms have a predisposing connective tissue disorder, leading to a weakness of the artery wall," says Caspar Grond-Ginsbach Ph.D. "This disorder can be diagnosed by a skin test."
Grond-Ginsbach, a geneticist and Holger Schnippering, M.D., a neurosurgeon, both at the University of Heidelberg in Germany, are lead authors of the report.
About 3 percent to 6 percent of adults age 30 and older have unruptured aneurysms and about 20 percent of them have multiple artery weaknesses, they say. Genes play a role in the development of some intracranial aneurysms, but why these aneurysms develop remains unknown. The findings suggest a genetic cause for two connective tissue defects.
Several years ago, the researchers discovered connective tissue defects in patients with cervical artery dissections, another vascular defect that causes stroke. They initiated this study because dissections and aneurysms might be related, they say.
Biopsies from the arterial wall of patients are rarely available, Grond-Ginsbach explains. Skin is considered a window to heritable connective tissue disorders, so researchers took skin samples from patients upper arms. They used an electron microscope to examine the collagen and elastic fibers of the skin.
The team took skin biopsies from 21 patients with intracranial aneurysm (average age 44) without signs of connective tissue disorders. Seventeen of them had suffered a subarachnoid stroke.
They found that seven patients had connective tissue mutations. These tissue alterations were not found in 10 patients who did not have intracranial aneurysms or in a database of more than 3,000 patients who had skin biopsies to diagnose dermatological problems. Four patients were classified as normal, although their electron microscope examinations seemed somewhat abnormal. So these findings might be an underestimation.
The researchers caution however, that the test is a scientific test rather than a screening tool for patient management.
Carole Bullock | EurekAlert
Finding new clues to brain cancer treatment
21.02.2020 | Case Western Reserve University
UIC researchers find unique organ-specific signature profiles for blood vessel cells
18.02.2020 | University of Illinois at Chicago
The operational speed of semiconductors in various electronic and optoelectronic devices is limited to several gigahertz (a billion oscillations per second). This constrains the upper limit of the operational speed of computing. Now researchers from the Max Planck Institute for the Structure and Dynamics of Matter in Hamburg, Germany, and the Indian Institute of Technology in Bombay have explained how these processes can be sped up through the use of light waves and defected solid materials.
Light waves perform several hundred trillion oscillations per second. Hence, it is natural to envision employing light oscillations to drive the electronic...
Most natural and artificial surfaces are rough: metals and even glasses that appear smooth to the naked eye can look like jagged mountain ranges under the microscope. There is currently no uniform theory about the origin of this roughness despite it being observed on all scales, from the atomic to the tectonic. Scientists suspect that the rough surface is formed by irreversible plastic deformation that occurs in many processes of mechanical machining of components such as milling.
Prof. Dr. Lars Pastewka from the Simulation group at the Department of Microsystems Engineering at the University of Freiburg and his team have simulated such...
Investigation of the temperature dependence of the skyrmion Hall effect reveals further insights into possible new data storage devices
The joint research project of Johannes Gutenberg University Mainz (JGU) and the Massachusetts Institute of Technology (MIT) that had previously demonstrated...
Researchers at Chalmers University of Technology, Sweden, recently completed a 5-year research project looking at how to make fibre optic communications systems more energy efficient. Among their proposals are smart, error-correcting data chip circuits, which they refined to be 10 times less energy consumptive. The project has yielded several scientific articles, in publications including Nature Communications.
Streaming films and music, scrolling through social media, and using cloud-based storage services are everyday activities now.
After helping develop a new approach for organic synthesis -- carbon-hydrogen functionalization -- scientists at Emory University are now showing how this approach may apply to drug discovery. Nature Catalysis published their most recent work -- a streamlined process for making a three-dimensional scaffold of keen interest to the pharmaceutical industry.
"Our tools open up whole new chemical space for potential drug targets," says Huw Davies, Emory professor of organic chemistry and senior author of the paper.
12.02.2020 | Event News
16.01.2020 | Event News
15.01.2020 | Event News
21.02.2020 | Medical Engineering
21.02.2020 | Health and Medicine
21.02.2020 | Physics and Astronomy