Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Gene therapy may increase cancer cure rates, medical physicists show

14.08.2002


An innovative combination of two medical procedures-gene therapy and radiation therapy--can increase cancer cure rates by significant amounts compared to the cure rates offered by conventional radiation therapy alone, a Virginia Commonwealth University (VCU) team has concluded. The researchers presented their results last month in Montreal at the annual conference of the American Association of Physicists in Medicine.



Known as genetic radiotherapy, the combined treatment can potentially increase cancer cure rates by up to 70% over present therapies that exclusively use radiation therapy, the researchers say. The combined technique is currently evolving from laboratory studies to human clinical trials.

In genetic radiotherapy, cancer cells are infected with a virus that makes tumor cells more sensitive to--and more easily destroyed by--radiation such as x-rays. At last month’s medical physics meeting, the VCU researchers presented a quantitative model predicting the increase in cancer cure rates with genetic radiotherapy.


"Our model incorporates human patient data from large radiotherapy clinical trials as well as experimental genetic therapy data from laboratory work," says Dr. Paul Keall, an assistant professor in VCU’s radiation oncology department.

To calculate the projected cure rates, the group considers the fraction of tumor cells that are genetically modified, or "transduced," by the injected virus. They also consider the sensitivity of the genetically transformed cells to radiation.

With present laboratory technology, the researchers predict an increase in cure rate of 15% when genetic radiotherapy is used instead of conventional radiation treatments on non-genetically-altered cancer cells. Exploring an ideal situation in which all of the cancer cells are genetically modified, they find the technique can theoretically increase the cancer cure rate by as much as 70%. In their model, a "cure" means a lack of tumor recurrence at the site where the tumor was treated.

"Thus, our results indicate that genetic radiotherapy has the potential to significantly improve cancer cure rates compared to current radiotherapy practices," says Keall. "Needed now are carefully controlled studies to test our predictions."


###
Meeting paper: "Radiobiological Predictions for Genetically Radiosensitized Tumors," by Paul Keall, PhD Guido Lammering, MD, Theodore Chung, MD, and Rupert Schmidt-Ullrich, MD, all at Department of Radiation Oncology, Virginia Commonwealth University, Richmond, VA, USA, paper MO-E-517B-7, Monday, July 15, 2002, 44th Annual AAPM Meeting, Montreal, Quebec.

Ben Stein | EurekAlert!
Further information:
http://www.aip.org/

More articles from Health and Medicine:

nachricht Inselspital: Fewer CT scans needed after cerebral bleeding
20.03.2019 | Universitätsspital Bern

nachricht Building blocks for new medications: the University of Graz is seeking a technology partner
19.03.2019 | Karl-Franzens-Universität Graz

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: The taming of the light screw

DESY and MPSD scientists create high-order harmonics from solids with controlled polarization states, taking advantage of both crystal symmetry and attosecond electronic dynamics. The newly demonstrated technique might find intriguing applications in petahertz electronics and for spectroscopic studies of novel quantum materials.

The nonlinear process of high-order harmonic generation (HHG) in gases is one of the cornerstones of attosecond science (an attosecond is a billionth of a...

Im Focus: Magnetic micro-boats

Nano- and microtechnology are promising candidates not only for medical applications such as drug delivery but also for the creation of little robots or flexible integrated sensors. Scientists from the Max Planck Institute for Polymer Research (MPI-P) have created magnetic microparticles, with a newly developed method, that could pave the way for building micro-motors or guiding drugs in the human body to a target, like a tumor. The preparation of such structures as well as their remote-control can be regulated using magnetic fields and therefore can find application in an array of domains.

The magnetic properties of a material control how this material responds to the presence of a magnetic field. Iron oxide is the main component of rust but also...

Im Focus: Self-healing coating made of corn starch makes small scratches disappear through heat

Due to the special arrangement of its molecules, a new coating made of corn starch is able to repair small scratches by itself through heat: The cross-linking via ring-shaped molecules makes the material mobile, so that it compensates for the scratches and these disappear again.

Superficial micro-scratches on the car body or on other high-gloss surfaces are harmless, but annoying. Especially in the luxury segment such surfaces are...

Im Focus: Stellar cartography

The Potsdam Echelle Polarimetric and Spectroscopic Instrument (PEPSI) at the Large Binocular Telescope (LBT) in Arizona released its first image of the surface magnetic field of another star. In a paper in the European journal Astronomy & Astrophysics, the PEPSI team presents a Zeeman- Doppler-Image of the surface of the magnetically active star II Pegasi.

A special technique allows astronomers to resolve the surfaces of faraway stars. Those are otherwise only seen as point sources, even in the largest telescopes...

Im Focus: Heading towards a tsunami of light

Researchers at Chalmers University of Technology and the University of Gothenburg, Sweden, have proposed a way to create a completely new source of radiation. Ultra-intense light pulses consist of the motion of a single wave and can be described as a tsunami of light. The strong wave can be used to study interactions between matter and light in a unique way. Their research is now published in the scientific journal Physical Review Letters.

"This source of radiation lets us look at reality through a new angle - it is like twisting a mirror and discovering something completely different," says...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

International Modelica Conference with 330 visitors from 21 countries at OTH Regensburg

11.03.2019 | Event News

Selection Completed: 580 Young Scientists from 88 Countries at the Lindau Nobel Laureate Meeting

01.03.2019 | Event News

LightMAT 2019 – 3rd International Conference on Light Materials – Science and Technology

28.02.2019 | Event News

 
Latest News

Laser processing is a matter for the head – LZH at the Hannover Messe 2019

25.03.2019 | Trade Fair News

A Varied Menu

25.03.2019 | Life Sciences

‘Time Machine’ heralds new era

25.03.2019 | Information Technology

VideoLinks
Science & Research
Overview of more VideoLinks >>>