Investment from the White Rose Technology Seedcorn Fund (WRTSF) - the venture capital fund owned by the universities of Leeds, Sheffield and York (UK) - has funded the completion of a series of significant technical milestones in the development of a new family of `immunologically-rational` adjuvants for vaccines, which are materially very different from the existing adjuvants based on aluminium salts and bacterial cell wall components.
Sheffield-based life science company Adjuvantix Ltd is now well positioned in its ambition to enter the $5 billion vaccine market(i).
The patented technology produces adjuvants that have greater effectiveness and no harmful side effects - addressing the key hurdles(ii) that have been preventing the development of vaccines for the infectious diseases such as hepatitis-B, hepatitis-C and HIV. Moreover the novel adjuvants should enable a new generation of therapeutic and prophylactic vaccines for chronic, non-infectious diseases such as diabetes, multiple sclerosis and stroke.
David Gough | alfa
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Researchers from TU Graz and their industry partners have unveiled a world first: the prototype of a robot-controlled, high-speed combined charging system (CCS) for electric vehicles that enables series charging of cars in various parking positions.
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Proteins must be folded correctly to fulfill their molecular functions in cells. Molecular assistants called chaperones help proteins exploit their inbuilt folding potential and reach the correct three-dimensional structure. Researchers at the Max Planck Institute of Biochemistry (MPIB) have demonstrated that actin, the most abundant protein in higher developed cells, does not have the inbuilt potential to fold and instead requires special assistance to fold into its active state. The chaperone TRiC uses a previously undescribed mechanism to perform actin folding. The study was recently published in the journal Cell.
Actin is the most abundant protein in highly developed cells and has diverse functions in processes like cell stabilization, cell division and muscle...
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17.08.2018 | Life Sciences
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