Water-filtered infrared-A (wIRA) irradiation has already been shown to enhance penetration of clinically used topically applied substances in humans through investigation of functional effects of penetrated substances like vasoconstriction by cortisone.A study of the Charité Berlin, just published on July 21st, 2008, in the interdisciplinary medical e-Journal "GMS German Medical Science" of the Association of the Scientific Medical Societies in Germany (AWMF) , investigated the influence of wIRA irradiation on the dermatopharmacokinetics of topically applied substances by use of optical methods, especially to localize penetrating substances, in a prospective randomised controlled study in humans.
In mode B, the skin surface was irradiated with wIRA over 30 min before application of the two dyes (water-filtered spectrum: 590-1400 nm with dominant amount of wIRA). In mode C, the two dyes were applied and immediately afterwards the skin was irradiated with wIRA over 30 min. In all modes, tape stripping started 30 min after application of the formulations. Main variable of interest was the ratio of the amount of the dye in the deeper (second) 10% of the stratum corneum to the amount of the dye in the upper 10% of the stratum corneum.
The penetration profiles of the hydrophilic fluorescein showed in case of pretreatment or treatment with wIRA (modes B and C) an increased penetration depth compared to the non-irradiated skin (mode A): The ratio of the amount of the dye in the deeper (second) 10% of the stratum corneum to the amount of the dye in the upper 10% of the stratum corneum showed medians for mode A of 0.017, for mode B of 0.084, for mode C of 0.104 (significant difference between modes).In contrast to fluorescein, the lipophilic curcumin showed no differences in the penetration kinetics, in reference to whether the skin was irradiated with wIRA or not. These effects were confirmed by laser scanning microscopy. Water-filtered infrared-A irradiation increased the hydration of the stratum corneum: transepidermal water loss rose from approximately 8.8 g m-2 h-1 before wIRA irradiation to 14.2 g m-2 h-1 after wIRA irradiation and skin hydration rose from 67 to 87 relative units. Skin surface temperature increased from 32.8°C before wIRA to 36.4°C after wIRA irradiation.
As most topically applied substances for the treatment of patients are mainly hydrophilic, wIRA can be used to improve the penetration of substances before or after application of substances, in the first case even of thermolabile substances. wIRA therefore has broad clinical relevance as a contact free alternative to an occlusive dressing, e.g. to improve the penetration and effect of topically applied cortisone in psoriasis or neurodermitis, of acyclovir in herpes zoster or herpes labialis, or of an acne therapeutic in acne papulopustulosa.
Water-filtered infrared-A (wIRA) as a special form of heat radiation (within 780-1400 nm) mainly consists of radiation with good penetration properties into tissue and therefore allows - compared to unfiltered heat radiation - a multiple energy transfer into tissue without irritating the skin, similar to the sun's heat radiation in moderate climatic zones. wIRA increases temperature, oxygen partial pressure, and perfusion in the tissue. In addition wIRA has non-thermal and non-thermic effects, which are based on putting direct stimuli on cells and cellular structures. wIRA can considerably alleviate pain and diminish elevated exudation and inflammation. wIRA can also show positive immunomodulatory effects.Extended clinical observation over months and years shows that skin, which is irradiated daily with wIRA, presents an improved appearance with good skin turgor and no signs of desiccation.
Wolfgang Müller | idw
Collagen nanofibrils in mammalian tissues get stronger with exercise
14.12.2018 | University of Illinois College of Engineering
New discoveries predict ability to forecast dementia from single molecule
12.12.2018 | UT Southwestern Medical Center
The more objects we make "smart," from watches to entire buildings, the greater the need for these devices to store and retrieve massive amounts of data quickly without consuming too much power.
Millions of new memory cells could be part of a computer chip and provide that speed and energy savings, thanks to the discovery of a previously unobserved...
What if, instead of turning up the thermostat, you could warm up with high-tech, flexible patches sewn into your clothes - while significantly reducing your...
A widely used diabetes medication combined with an antihypertensive drug specifically inhibits tumor growth – this was discovered by researchers from the University of Basel’s Biozentrum two years ago. In a follow-up study, recently published in “Cell Reports”, the scientists report that this drug cocktail induces cancer cell death by switching off their energy supply.
The widely used anti-diabetes drug metformin not only reduces blood sugar but also has an anti-cancer effect. However, the metformin dose commonly used in the...
A research team from the University of Zurich has developed a new drone that can retract its propeller arms in flight and make itself small to fit through narrow gaps and holes. This is particularly useful when searching for victims of natural disasters.
Inspecting a damaged building after an earthquake or during a fire is exactly the kind of job that human rescuers would like drones to do for them. A flying...
Over the last decade, there has been much excitement about the discovery, recognised by the Nobel Prize in Physics only two years ago, that there are two types...
12.12.2018 | Event News
10.12.2018 | Event News
06.12.2018 | Event News
14.12.2018 | Power and Electrical Engineering
14.12.2018 | Physics and Astronomy
14.12.2018 | Physics and Astronomy