According to a study in Respirology published by Wiley-Blackwell, treatments with oral Bosentan reduces resistance in blood flow – allowing the heart and lungs to work more efficiently and in turn, enables patients to increase exercise capacity and quality of life.
PAH is a syndrome where one experiences continuous high blood pressure in the pulmonary arteries, or the blood vessels supplying blood to the lungs. In PAH, the heart has to work very hard to pump against the high resistance and eventually weakens. When it loses the ability to pump enough blood, heart failure occurs and often death.
Although there is no cure for PAH, there are treatments that are beneficial to the patients. Bosentan is an oral endothelin receptor antagonist that significantly improves functional status, increase blood flow and survival of patients.
Lead author, Mr. Geoff Strange says, “Quality of life is an important consideration in the treatment of diseases such as PAH, in which prognosis is typically poor. In such chronic diseases, patients view improvement in quality of life as an important measure of treatment success.”
After three months of Bosentan treatment, patients showed improvements in their exercise capacity in the six minute walk test (6MWT), as well as domains that measured quality of life. Although the assessment of quality of life and 6MWT provides complementary data at individual time points, they did not correlate over time as a response to therapy.
Professor Eli Gabbay, from the Royal Perth Hospital and The University of Western Australia adds, “While quality of life and 6MWT data were parallel at individual points, quality of life may improve on Bosentan therapy independent of the improvements in 6MWT. The quality of life domains should be specifically assessed to improve the monitoring of patients with PAH as changes in quality of life cannot be extrapolated from routine clinical variables.”
Alina Boey | alfa
Discovery shows promise for treating Huntington's Disease
05.08.2020 | Ecole Polytechnique Fédérale de Lausanne
Carbon monoxide improves endurance performance
05.08.2020 | Universität Bayreuth
Scientists at the Fraunhofer Institute for Laser Technology ILT have come up with a striking new addition to contact stamping technologies in the ERDF research project ScanCut. In collaboration with industry partners from North Rhine-Westphalia, the Aachen-based team of researchers developed a hybrid manufacturing process for the laser cutting of thin-walled metal strips. This new process makes it possible to fabricate even the tiniest details of contact parts in an eco-friendly, high-precision and efficient manner.
Plug connectors are tiny and, at first glance, unremarkable – yet modern vehicles would be unable to function without them. Several thousand plug connectors...
An international research team has found a new approach that may be able to reduce bone loss in osteoporosis and maintain bone health.
Osteoporosis is the most common age-related bone disease which affects hundreds of millions of individuals worldwide. It is estimated that one in three women...
Traditional single-cell sequencing methods help to reveal insights about cellular differences and functions - but they do this with static snapshots only...
“Core-shell” clusters pave the way for new efficient nanomaterials that make catalysts, magnetic and laser sensors or measuring devices for detecting electromagnetic radiation more efficient.
Whether in innovative high-tech materials, more powerful computer chips, pharmaceuticals or in the field of renewable energies, nanoparticles – smallest...
An international research team with Prof. Cornelia Denz from the Institute of Applied Physics at the University of Münster develop for the first time light fields using caustics that do not change during propagation. With the new method, the physicists cleverly exploit light structures that can be seen in rainbows or when light is transmitted through drinking glasses.
Modern applications as high resolution microsopy or micro- or nanoscale material processing require customized laser beams that do not change during...
23.07.2020 | Event News
21.07.2020 | Event News
07.07.2020 | Event News
06.08.2020 | Earth Sciences
06.08.2020 | Power and Electrical Engineering
06.08.2020 | Life Sciences