Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Failure of the first attempt at assisted reproduction justifies at least one additional cycle

09.07.2008
Research into the effect of age and the number of times women undergo assisted reproduction technology (ART) shows that for younger women, the overwhelming majority achieve a pregnancy within the first two attempts, whereas women over the age of 40 had a more consistent, but lower, pregnancy rate of about 20% throughout their first four attempts.

Mr Simon Hong told the 24th annual meeting of the European Society of Human Reproduction and Embryology in Barcelona today (Tuesday): “The purpose of this study was to try to identify, at least in our practice, if a patient in a certain age group should repeat a cycle and how many.

We found that the overwhelming majority of women who became pregnant (96%) achieved pregnancy by their second attempt, although the probability of a pregnancy after the third and fourth attempts remains encouraging. These results confirm that there is negative correlation between achieving pregnancy and increasing the number of attempts. Nonetheless, for all patients undergoing ART treatment, failure of the first attempt justifies at least one additional cycle.”

Mr Hong is a researcher at the Center for Reproductive Medicine and Infertility, Cornell University (New York, USA), which is headed by Professor Gianpiero Palermo who pioneered the intracytoplasmic sperm injection (ICSI) technique.

Mr Hong and his colleagues analysed 8,970 ICSI cycles carried out in 6,719 patients treated between September 1993 and December 2007. The women were categorised into three groups: those aged 35 or younger, those aged 36-39, and those aged 40 and over. The average age was 36.5. Mr Hong examined the number of women achieving pregnancy at each attempt in each age group.

“The overall pregnancy rate, regardless of the mothers’ age, was 39.2% – 3,515 pregnancies out of 8,970 cycles. The highest number of ART attempts was eight, but only a handful of patients had six or more attempts,” said Mr Hong.

Among all patients of all ages who achieved a pregnancy, 79.7% were successful in their first attempt, 16% in their second, and 3.4% in their third. When Mr Hong looked at the different age groups, those aged 35 and under had an overall pregnancy rate of 50.8%. In this age group, 53.7% of women became pregnant at their first attempt, and this decreased to 43%, 33%, 23% and 18.2% at the second, third, fourth and fifth attempts, respectively. There were no successful pregnancies beyond the fifth attempt.

In the 36-39 age group, the overall pregnancy rate was 39.5%. Again, there was a steady decrease from 41.5% at the first attempt to 25% at the fourth attempt. In women aged 40 and over, the overall pregnancy rate was 24.1%, ranging from 24.6% to 18.5%, and there were no significant differences in the proportion of women becoming pregnant between the first and the fourth attempts.

Mr Hong said: “We observed a more consistent pregnancy rate in the older age groups starting at 36 years. This is probably because older women have a lower pregnancy rate from the time of their first attempt, and this rate remains consistent thereafter. It is possible that the incidence of embryo aneuploidy in this age group is the over-riding factor affecting pregnancy outcome in this age group.

“For the group aged 36-39, the pregnancy rate was 25% at the fourth attempt; however, it only includes four pregnancies out of 16. The large majority of pregnancies were evenly distributed between the first three attempts. For the group aged 40 and over, a consistent pregnancy rate of about 20% throughout the first four attempts was observed. From this, it seems that for the older age groups, the number of attempts that provide a consistent pregnancy rate extends from two to four.

“An ART cycle is financially burdensome, but most importantly an emotional endeavour. It also requires exposure to medications and to, although minor, a surgical procedure. From our findings, it appears that younger patients undergoing two ART attempts benefit from the highest chances of pregnancy. While women in the higher age groups (aged 36 and older) may benefit from a successful outcome when undergoing a third or perhaps fourth attempt.”

Mr Hong concluded: “It is difficult to determine at which attempt a patient should end her pursuit to conceive through assisted reproduction. We feel that couples should be given all available information to make the most informed decision possible. Therefore, we believe that couples should be offered counselling that describes the chances of a successful pregnancy at each individual ART attempt for their specific age group.”

Sarah De Potter | alfa
Further information:
http://www.eshre.com

More articles from Health and Medicine:

nachricht Researchers have identified areas of the retina that change in mild Alzheimer's disease
16.09.2019 | Universidad Complutense de Madrid

nachricht Two commonly used uveitis drugs perform similarly in NIH-funded clinical trial
11.09.2019 | NIH/National Eye Institute

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Tomorrow´s coolants of choice

Scientists assess the potential of magnetic-cooling materials

Later during this century, around 2060, a paradigm shift in global energy consumption is expected: we will spend more energy for cooling than for heating....

Im Focus: The working of a molecular string phone

Researchers from the Department of Atomically Resolved Dynamics of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg, the University of Potsdam (both in Germany) and the University of Toronto (Canada) have pieced together a detailed time-lapse movie revealing all the major steps during the catalytic cycle of an enzyme. Surprisingly, the communication between the protein units is accomplished via a water-network akin to a string telephone. This communication is aligned with a ‘breathing’ motion, that is the expansion and contraction of the protein.

This time-lapse sequence of structures reveals dynamic motions as a fundamental element in the molecular foundations of biology.

Im Focus: Milestones on the Way to the Nuclear Clock

Two research teams have succeeded simultaneously in measuring the long-sought Thorium nuclear transition, which enables extremely precise nuclear clocks. TU Wien (Vienna) is part of both teams.

If you want to build the most accurate clock in the world, you need something that "ticks" very fast and extremely precise. In an atomic clock, electrons are...

Im Focus: Graphene sets the stage for the next generation of THz astronomy detectors

Researchers from Chalmers University of Technology have demonstrated a detector made from graphene that could revolutionize the sensors used in next-generation space telescopes. The findings were recently published in the scientific journal Nature Astronomy.

Beyond superconductors, there are few materials that can fulfill the requirements needed for making ultra-sensitive and fast terahertz (THz) detectors for...

Im Focus: Physicists from Stuttgart prove the existence of a supersolid state of matte

A supersolid is a state of matter that can be described in simplified terms as being solid and liquid at the same time. In recent years, extensive efforts have been devoted to the detection of this exotic quantum matter. A research team led by Tilman Pfau and Tim Langen at the 5th Institute of Physics of the University of Stuttgart has succeeded in proving experimentally that the long-sought supersolid state of matter exists. The researchers report their results in Nature magazine.

In our everyday lives, we are familiar with matter existing in three different states: solid, liquid, or gas. However, if matter is cooled down to extremely...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Society 5.0: putting humans at the heart of digitalisation

10.09.2019 | Event News

Interspeech 2019 conference: Alexa and Siri in Graz

04.09.2019 | Event News

AI for Laser Technology Conference: optimizing the use of lasers with artificial intelligence

29.08.2019 | Event News

 
Latest News

Too much of a good thing: overactive immune cells trigger inflammation

16.09.2019 | Life Sciences

Scientists create a nanomaterial that is both twisted and untwisted at the same time

16.09.2019 | Materials Sciences

Researchers have identified areas of the retina that change in mild Alzheimer's disease

16.09.2019 | Health and Medicine

VideoLinks
Science & Research
Overview of more VideoLinks >>>