Dr. Karin Middelburg, from the University Medical Center Groningen, Groningen, The Netherlands, said that the study, which looked at the quality of general movements in infants at the age of three months, showed that singleton children born after IVF were not at increased risk for abnormal general movements.
This suggests that they are not at increased risk of cerebral palsy (CP) or other neurodevelopmental disorders compared with their peers born from natural conception in sub-fertile couples who were referred to the fertility clinic for fertility evaluation or treatment, she said.
In the past, there has been concern that babies born after IVF were at risk of such disorders because of the association with preterm birth and low birth weight, so this was an important question to answer, said Dr. Middelburg. The research team investigated 68 singleton babies born after IVF/ICSI with controlled ovarian hyperstimulation (the conventional method, where the ovaries are stimulated with hormones to produce multiple oocytes (egg cells)) and 57 singletons born following IVF/ICSI in a modified natural cycle of oocyte production, where the one egg cell which develops naturally is utilised.
In this latter method, the need for hormonal medication is much reduced, although minimal hormonal support is still necessary in order to prevent spontaneous ovulation. Ninety singleton babies born to sub-fertile parents who conceived naturally during fertility evaluation or while on the waiting list for treatment were used as a control group.
The researchers studied the babies’ neurodevelopment by assessing their spontaneous movements, known as general movements, early in infancy. “The quality of these movements reflects the integrity of the young brain and is related to developmental disorders such as CP, minor neurological dysfunction, and behavioural problems when children reach school age,” said Dr. Middelburg.
Data on quality of movements in the general population was also available by assessing 450 singleton children at child welfare clinics. The researchers found that the quality of general movements of singletons born following conventional IVF and IVF using the modified natural cycle were similar to that of the singletons born to sub-fertile couples.
“However, we were intrigued to find that sub-fertility appeared to relate to less-than-optimal neurological condition in early infancy,” said Dr. Middelburg. “Mildly abnormal general movements occurred more frequently in the children born to sub-fertile parents than in the general population, and this suggests that factors relating to sub-fertility rather than to IVF procedures come into play.”
The children in the study are currently being assessed a number of times until their second birthday. The team intends to follow up the work by recalling them for further assessment around their fourth birthday. “Some developmental disorders, such as cognitive and behavioural problems are only fully detectable when children grow older,” said Dr. Middelburg. “This study is important, not only because it informs us about the effect of hormonal stimulation on brain development, but also because we believe that many factors associated with sub-fertility may be implicated in the neurological condition of the resulting children. This is an intriguing finding that deserves further investigation.”
Sarah De Potter | alfa
Unique brain 'fingerprint' can predict drug effectiveness
11.07.2018 | McGill University
Direct conversion of non-neuronal cells into nerve cells
03.07.2018 | Universitätsmedizin der Johannes Gutenberg-Universität Mainz
For the first time ever, scientists have determined the cosmic origin of highest-energy neutrinos. A research group led by IceCube scientist Elisa Resconi, spokesperson of the Collaborative Research Center SFB1258 at the Technical University of Munich (TUM), provides an important piece of evidence that the particles detected by the IceCube neutrino telescope at the South Pole originate from a galaxy four billion light-years away from Earth.
To rule out other origins with certainty, the team led by neutrino physicist Elisa Resconi from the Technical University of Munich and multi-wavelength...
For the first time a team of researchers have discovered two different phases of magnetic skyrmions in a single material. Physicists of the Technical Universities of Munich and Dresden and the University of Cologne can now better study and understand the properties of these magnetic structures, which are important for both basic research and applications.
Whirlpools are an everyday experience in a bath tub: When the water is drained a circular vortex is formed. Typically, such whirls are rather stable. Similar...
Physicists working with Roland Wester at the University of Innsbruck have investigated if and how chemical reactions can be influenced by targeted vibrational excitation of the reactants. They were able to demonstrate that excitation with a laser beam does not affect the efficiency of a chemical exchange reaction and that the excited molecular group acts only as a spectator in the reaction.
A frequently used reaction in organic chemistry is nucleophilic substitution. It plays, for example, an important role in in the synthesis of new chemical...
Optical spectroscopy allows investigating the energy structure and dynamic properties of complex quantum systems. Researchers from the University of Würzburg present two new approaches of coherent two-dimensional spectroscopy.
"Put an excitation into the system and observe how it evolves." According to physicist Professor Tobias Brixner, this is the credo of optical spectroscopy....
Ultra-short, high-intensity X-ray flashes open the door to the foundations of chemical reactions. Free-electron lasers generate these kinds of pulses, but there is a catch: the pulses vary in duration and energy. An international research team has now presented a solution: Using a ring of 16 detectors and a circularly polarized laser beam, they can determine both factors with attosecond accuracy.
Free-electron lasers (FELs) generate extremely short and intense X-ray flashes. Researchers can use these flashes to resolve structures with diameters on the...
13.07.2018 | Event News
12.07.2018 | Event News
03.07.2018 | Event News
16.07.2018 | Physics and Astronomy
16.07.2018 | Life Sciences
16.07.2018 | Earth Sciences