Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

10 percent of healthy people in study had injury from 'silent strokes'

30.06.2008
American Heart Association rapid access journal report

A recent study found that about 10 percent of the apparently healthy middle-aged participants with no symptoms of stroke were injured from "silent strokes," researchers report in Stroke: Journal of the American Heart Association.

Silent cerebral infarction (SCI), or "silent stroke," is a brain injury likely caused by a blood clot interrupting blood flow in the brain. It's a risk factor for future strokes and a sign of progressive brain damage that may result in long-term dementia.

"The findings reinforce the need for early detection and treatment of cardiovascular risk factors in midlife," said Sudha Seshadri, M.D., co-author of the study and associate professor of neurology at Boston University School of Medicine. "This is especially true since SCIs have been associated with an increased risk of incident stroke and cognitive impairment."

Researchers evaluated magnetic resonance imaging (MRI) from about 2,000 people, average age 62, who are part of the Framingham Offspring Study (children of participants in the original Framingham Heart Study). The offspring have undergone clinical examinations every four to eight years.

Among patients who displayed no symptoms of stroke, 10.7 percent had SCIs on routine brain MRI, researchers said. Previous estimates of SCIs ranged from 5.8 percent to 17.7 percent depending on age, ethnicity and other issues. Of those in the study with SCIs, 84 percent had a single lesion.

The study is the first to correlate the total score of the Framingham Stroke Risk Profile to prevalence of SCI. The risk profile estimates the 10-year probability of having a stroke. The factors in the profile are age, systolic blood pressure, antihypertensive therapy, diabetes mellitus, cigarette smoking, cardiovascular disease, left ventricular hypertrophy and atrial fibrillation (AF).

All the components of the Framingham Stroke Risk Profile were positively associated with an increased prevalence of SCI. For the first time, researchers found a significant correlation between AF and silent cerebral infarction. AF is the most common form of heart arrhythmia, or irregular heartbeat in people older than 65.

"In our data, AF increased the risk of prevalent SCI more than two-fold," Seshadri said. Hypertension and systolic blood pressure were also associated with an increased prevalence of SCI.

Risk factors for stroke are also risk factors for AF. Hypertension and other factors that make it more likely individuals will experience AF also predispose those people to clinical stroke and probably to SCI. AF, therefore, may be a simultaneous outcome rather than a cause of SCI, researchers said.

The observational data could not indicate if screening for and appropriately treating AF would reduce the population burden of silent stroke, researchers said.

The study also found that high systolic blood pressure, hypertension and elevated levels of blood homocysteine, a sulfur-containing amino acid found in the blood, were other risk factors commonly associated with stroke that also raised participants' chances of having SCI. Hypertension consistently has been implicated as a risk factor of SCI. Neither age nor gender significantly changed the effect of any of the risk factors on SCI.

Researchers' ability to generalize findings for other ethnic groups is limited because participants in the Framingham study are mostly of European descent.

"The significant relationship between hypertension, elevated serum homocysteine, carotid artery disease and prevalent SCI underscores the importance of current guidelines for the early diagnosis and prevention of hypertension and atherosclerosis and their risk factors," Seshadri said.

Bridgette McNeill | EurekAlert!
Further information:
http://www.heart.org

More articles from Health and Medicine:

nachricht Study tracks inner workings of the brain with new biosensor
16.08.2018 | Rheinische Friedrich-Wilhelms-Universität Bonn

nachricht Foods of the future
15.08.2018 | Georg-August-Universität Göttingen

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Color effects from transparent 3D-printed nanostructures

New design tool automatically creates nanostructure 3D-print templates for user-given colors
Scientists present work at prestigious SIGGRAPH conference

Most of the objects we see are colored by pigments, but using pigments has disadvantages: such colors can fade, industrial pigments are often toxic, and...

Im Focus: Unraveling the nature of 'whistlers' from space in the lab

A new study sheds light on how ultralow frequency radio waves and plasmas interact

Scientists at the University of California, Los Angeles present new research on a curious cosmic phenomenon known as "whistlers" -- very low frequency packets...

Im Focus: New interactive machine learning tool makes car designs more aerodynamic

Scientists develop first tool to use machine learning methods to compute flow around interactively designable 3D objects. Tool will be presented at this year’s prestigious SIGGRAPH conference.

When engineers or designers want to test the aerodynamic properties of the newly designed shape of a car, airplane, or other object, they would normally model...

Im Focus: Robots as 'pump attendants': TU Graz develops robot-controlled rapid charging system for e-vehicles

Researchers from TU Graz and their industry partners have unveiled a world first: the prototype of a robot-controlled, high-speed combined charging system (CCS) for electric vehicles that enables series charging of cars in various parking positions.

Global demand for electric vehicles is forecast to rise sharply: by 2025, the number of new vehicle registrations is expected to reach 25 million per year....

Im Focus: The “TRiC” to folding actin

Proteins must be folded correctly to fulfill their molecular functions in cells. Molecular assistants called chaperones help proteins exploit their inbuilt folding potential and reach the correct three-dimensional structure. Researchers at the Max Planck Institute of Biochemistry (MPIB) have demonstrated that actin, the most abundant protein in higher developed cells, does not have the inbuilt potential to fold and instead requires special assistance to fold into its active state. The chaperone TRiC uses a previously undescribed mechanism to perform actin folding. The study was recently published in the journal Cell.

Actin is the most abundant protein in highly developed cells and has diverse functions in processes like cell stabilization, cell division and muscle...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

LaserForum 2018 deals with 3D production of components

17.08.2018 | Event News

Within reach of the Universe

08.08.2018 | Event News

A journey through the history of microscopy – new exhibition opens at the MDC

27.07.2018 | Event News

 
Latest News

Smallest transistor worldwide switches current with a single atom in solid electrolyte

17.08.2018 | Physics and Astronomy

Robots as Tools and Partners in Rehabilitation

17.08.2018 | Information Technology

Climate Impact Research in Hannover: Small Plants against Large Waves

17.08.2018 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>