Cancer vaccine targets immortalisation factor in cancer cell
A new vaccination strategy targeting telomerase, one of the enzymes responsible for making cancer cells immortal, has been developed at the Norwegian Radium Hospital. “The vaccine might offer a means of stabilising cancer”, states Professor Gustav Gaudernack at a press conference at the 18th UICC International Cancer Congress in Oslo this week.
A new vaccination strategy targeting telomerase, one of the enzymes responsible for making cancer cells immortal, has been tested by Professor Trond Buanes on patients with pancreatic cancer at Ullevaal University Hospital. The vaccine was developed by a research team headed by Professor Gustav Gaudernack at the Norwegian Radium Hospital.
Initiated in September 2000, the ongoing study comprises 31 patients with inoperable pancreatic cancer who have been treated with the vaccine. With the optimal dose, the majority of the patients have experienced an immune response to the vaccine. There is a trend for these patients to live longer than those who failed to respond, and for the patients who received a higher dose to live longer than those who received the lower dose. Gaudernack warns that since there was little evidence of tumour reduction, this is not a cure but rather a means of stabilising the cancer.
The vaccine has been designed to encourage the immune system to respond to telomerase produced by cancer cells. Found in virtually all types of cancer, this target is responsible for giving cancer cells an unlimited capacity to divide. The immunologists’ aim is to stimulate the patient’s own immune system to recognise this protein and destroy the cancer cells while leaving the healthy cells alone. There are still some questions related to the long-term safety of the vaccine.
Gaudernack emphasises the need to verify these results by controlled studies on larger groups of patients.
These research efforts are supported by the Norwegian Cancer Society and the Norwegian biotech company GemVax.
Contacts:
Researcher Gustav Gaudernack, Norwegian Radium Hospital
Tel +47 22 93 40 00
18th UICC International Cancer Congress,
Press Office: Hanna Hånes
Tel +47 901 56 040, e-mail: haanes@oslo2002.org
Media Contact
More Information:
http://www.kreft.no/All latest news from the category: Health and Medicine
This subject area encompasses research and studies in the field of human medicine.
Among the wide-ranging list of topics covered here are anesthesiology, anatomy, surgery, human genetics, hygiene and environmental medicine, internal medicine, neurology, pharmacology, physiology, urology and dental medicine.
Newest articles
Superradiant atoms could push the boundaries of how precisely time can be measured
Superradiant atoms can help us measure time more precisely than ever. In a new study, researchers from the University of Copenhagen present a new method for measuring the time interval,…
Ion thermoelectric conversion devices for near room temperature
The electrode sheet of the thermoelectric device consists of ionic hydrogel, which is sandwiched between the electrodes to form, and the Prussian blue on the electrode undergoes a redox reaction…
Zap Energy achieves 37-million-degree temperatures in a compact device
New publication reports record electron temperatures for a small-scale, sheared-flow-stabilized Z-pinch fusion device. In the nine decades since humans first produced fusion reactions, only a few fusion technologies have demonstrated…
