A natural method of disarming some types of viruses may enable scientists to someday treat infections with HIV, the AIDS virus, according to a virologist at Jefferson Medical College.
Taking the lead from the common fruit fly, yeast and worms, scientists have recently shown that it may be possible to use small pieces of genetic material called short interfering RNAs (siRNAs) to inhibit HIV from making more copies of itself.
The process, called RNA interference (RNAi), was first discovered in 1998. It is so novel, says virologist Roger J. Pomerantz, M.D., professor of medicine, biochemistry and molecular pharmacology and chief of the division of infectious diseases at Jefferson Medical College of Thomas Jefferson University in Philadelphia, that scientists only now are beginning to understand its potential to treat disease. "Whats so exciting for HIV therapy is that it may be a potent way of specifically inhibiting the virus," says Dr. Pomerantz, whose commentary accompanies a paper on the topic in the July 2002 issue of Nature Medicine.
Steve Benowitz | EurekAlert!
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