Neurologists have identified the illness as a new disorder which causes symptoms ranging from a transverse myelitis syndrome, inflammation of the spinal cord, in one patient to mild weakness, fatigue, numbness and tingling in arms and legs. Researchers are classifying this condition as an immune polyradiculoneuropathy, (a disease of the peripheral nerves and spinal nerve roots) and it has been referred to as “progressive inflammatory neuropathy.” Details about the initial epidemiology investigation were described in an article in the Morbidity and Mortality Weekly Report on February 8.
The current presentation focuses on the clinical description of patients who worked at a Minnesota pork processing plant. Other cases associated with working at a pork processing plant have been reported in Indiana and Nebraska. All of the Minnesota cases had evidence of nerve involvement, typically affecting the legs and likely caused by an inflammatory process.
Electrodiagnostic tests showed that the patients had damage to the nerves at the root level, adjacent to the spinal cord, and at the farthest reaches of motor nerves, near the connection with muscle. Thirteen out of 15 patients had elevated protein levels in their cerebrospinal (brain and spinal cord) fluid. Most patients had evidence of inflammation on spinal MRI examinations. All had evidence of activation of their immune systems. This was shown by a pattern of specific antibody production that has not been seen before.
“This appears to be a new syndrome of immune-mediated polyradiculoneuropathy, or more simply, a novel neurological disorder caused by an immune system response to something in the workplace environment shared by these individuals,” said study author Daniel Lachance, MD, of the Mayo Clinic in Rochester, MN, and a Fellow member of the American Academy of Neurology.
Lachance said the researchers will present additional details at the AAN Annual Meeting.
The American Academy of Neurology, an association of more than 21,000 neurologists and neuroscience professionals, is dedicated to improving patient care through education and research. A neurologist is a doctor with specialized training in diagnosing, treating and managing disorders of the brain and nervous system such as Alzheimer’s disease, epilepsy, multiple sclerosis, Parkinson’s disease, and stroke.
Rachel Seroka | EurekAlert!
Unique brain 'fingerprint' can predict drug effectiveness
11.07.2018 | McGill University
Direct conversion of non-neuronal cells into nerve cells
03.07.2018 | Universitätsmedizin der Johannes Gutenberg-Universität Mainz
For the first time ever, scientists have determined the cosmic origin of highest-energy neutrinos. A research group led by IceCube scientist Elisa Resconi, spokesperson of the Collaborative Research Center SFB1258 at the Technical University of Munich (TUM), provides an important piece of evidence that the particles detected by the IceCube neutrino telescope at the South Pole originate from a galaxy four billion light-years away from Earth.
To rule out other origins with certainty, the team led by neutrino physicist Elisa Resconi from the Technical University of Munich and multi-wavelength...
For the first time a team of researchers have discovered two different phases of magnetic skyrmions in a single material. Physicists of the Technical Universities of Munich and Dresden and the University of Cologne can now better study and understand the properties of these magnetic structures, which are important for both basic research and applications.
Whirlpools are an everyday experience in a bath tub: When the water is drained a circular vortex is formed. Typically, such whirls are rather stable. Similar...
Physicists working with Roland Wester at the University of Innsbruck have investigated if and how chemical reactions can be influenced by targeted vibrational excitation of the reactants. They were able to demonstrate that excitation with a laser beam does not affect the efficiency of a chemical exchange reaction and that the excited molecular group acts only as a spectator in the reaction.
A frequently used reaction in organic chemistry is nucleophilic substitution. It plays, for example, an important role in in the synthesis of new chemical...
Optical spectroscopy allows investigating the energy structure and dynamic properties of complex quantum systems. Researchers from the University of Würzburg present two new approaches of coherent two-dimensional spectroscopy.
"Put an excitation into the system and observe how it evolves." According to physicist Professor Tobias Brixner, this is the credo of optical spectroscopy....
Ultra-short, high-intensity X-ray flashes open the door to the foundations of chemical reactions. Free-electron lasers generate these kinds of pulses, but there is a catch: the pulses vary in duration and energy. An international research team has now presented a solution: Using a ring of 16 detectors and a circularly polarized laser beam, they can determine both factors with attosecond accuracy.
Free-electron lasers (FELs) generate extremely short and intense X-ray flashes. Researchers can use these flashes to resolve structures with diameters on the...
13.07.2018 | Event News
12.07.2018 | Event News
03.07.2018 | Event News
18.07.2018 | Life Sciences
18.07.2018 | Life Sciences
18.07.2018 | Information Technology