A lot of diseases are known to the medical science, each of the diseases having its own symptoms. Nevertheless, all diseases have something in common, regardless of the illness cause and the patients` individual reactions. These generalised regularities inherent in all diseases are called general pathology. Physicians can easily recognise anatomical and physiological abnormalities, but some symptoms are not evident. These abnormalities appear to be a presage of a disease, and after the recovery they are retained for some time by the organism as a reminder of the disease. The signs of such asymptomatic pathology are, brought to light, with the help of biochemical, immunological, biophysical, molecular-biological and molecular-genetic research. For twenty years the staff of the Medical Genetic Research Center (Russian Academy of Medical Sciences) have been researching various latent signs of general pathology comparing the value of information they carry. The scientists have come to the conclusion that some, specific leukocytes` proteins are more sensitive.
The leukocytes genome reacts violently to the pathological state of the organism, as a result it changes the content of proteins called 53? and 43? in these cells. In fact, the indication of general illness is the ratio of these proteins content to the content of the histon protein of leukocytes. The scientists have examined 1,672 patients suffering from different types of various diseases, both heritable and acquired, including phenylketonuria, Down`s syndrome, psoriasis, stomach ulcer, bronchial asthma, oncological diseases, hepatitis, herpes, tuberculosis and many others. The researchers have also focused on the radiation sickness, cardiovascular diseases, illnesses of kidneys, liver and bile-ducts, tumours, diseases of bones and joints and gastrointestinal tract. Without exception, the ratio of proteins of all the examined patients has turned out abnormal. This implies high probability diagnostics - nobody has managed yet to achieve one-hundred-percent diagnostics.
Up to now the pre-clinical diagnostics used other indications, for instance, the scientists determined the concentration of various cell types or the content of antibodies and some other substances in blood. However, these indications may fail the diagnostics as they do not show up with all diseases or with all patients. The 53K and 43K proteins relative content has never failed the researchers. There exist other signs of general pathology, which can be determined by a physician. These signs can include oedema, pathologies of blood circulation, thrombosis, inflammation and some others. However, it is not easy to use these signs for the early diagnostics purposes, since with different individuals and at different phases of illness development these signs do not only reflect the pathological process but also indicate the adaptive response of the organism.
Natalia Reznik | alfa
Candidate Ebola vaccine still effective when highly diluted, macaque study finds
21.10.2019 | NIH/National Institute of Allergy and Infectious Diseases
Autism spectrum disorder risk linked to insufficient placental steroid
21.10.2019 | Children's National Hospital
A very special kind of light is emitted by tungsten diselenide layers. The reason for this has been unclear. Now an explanation has been found at TU Wien (Vienna)
It is an exotic phenomenon that nobody was able to explain for years: when energy is supplied to a thin layer of the material tungsten diselenide, it begins to...
Researchers at Ludwig-Maximilians-Universitaet (LMU) in Munich have explored the initial consequences of the interaction of light with molecules on the surface of nanoscopic aerosols.
The nanocosmos is constantly in motion. All natural processes are ultimately determined by the interplay between radiation and matter. Light strikes particles...
Particles that are mere nanometers in size are at the forefront of scientific research today. They come in many different shapes: rods, spheres, cubes, vesicles, S-shaped worms and even donut-like rings. What makes them worthy of scientific study is that, being so tiny, they exhibit quantum mechanical properties not possible with larger objects.
Researchers at the Center for Nanoscale Materials (CNM), a U.S. Department of Energy (DOE) Office of Science User Facility located at DOE's Argonne National...
A new research project at the TH Mittelhessen focusses on the development of a novel light weight design concept for leisure boats and yachts. Professor Stephan Marzi from the THM Institute of Mechanics and Materials collaborates with Krake Catamarane, which is a shipyard located in Apolda, Thuringia.
The project is set up in an international cooperation with Professor Anders Biel from Karlstad University in Sweden and the Swedish company Lamera from...
Superconductivity has fascinated scientists for many years since it offers the potential to revolutionize current technologies. Materials only become superconductors - meaning that electrons can travel in them with no resistance - at very low temperatures. These days, this unique zero resistance superconductivity is commonly found in a number of technologies, such as magnetic resonance imaging (MRI).
Future technologies, however, will harness the total synchrony of electronic behavior in superconductors - a property called the phase. There is currently a...
02.10.2019 | Event News
02.10.2019 | Event News
19.09.2019 | Event News
21.10.2019 | Materials Sciences
21.10.2019 | Materials Sciences
21.10.2019 | Medical Engineering