Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Do fungi cause retinopathies?

10.03.2008
A research team from the Centro de Biología Molecular Severo Ochoa (CSIC-UAM) working in collaboration with the Clínica Barraquer in Barcelona have focused their research on the study of fungi as a possible cause of strange retinopathies such as AZOOR.

There are several retinopathies of unknown cause; among them AZOOR, Multifocal choroiditis, Serpiginous choroiditis, Idiopathic Blind Spot Enlargement Syndrome … etc.

The progressive nature of these conditions causes most patients to gradually lose their vision until many of them are left blinded. It must be considered that not only is the diagnosis most patients not easy, especially in the early stages of the disease, but that the identification of faster diagnosis methods would lead to the correct treatment sooner, avoiding in this manner the increasing loss of visual acuity.

Without a doubt, discovering the cause of each of these retinopathies would bring new hope of their treatments. Three years ago, with the help and financial support of ONCE, a research team led by Luis Carrasco professor of microbiology at the Universidad Autónoma de Madrid, noticed that a patient suffering form AZOOR was also infected by a type of yeast called Candida famata. In collaboration with the Clínica Barraquer, these studies have been extended to other patients with AZOOR or with Serpiginous choroiditis.

In January this year, information about the fungal infection in these patients was published in the Journal of Clinical Microbiology

(Pisa, D., M. Ramos, P. García, R. Escoto, R. Barraquer, S. Molina y L. Carrasco. Fungal infection in patients with Serpiginous choroiditis or acute zonal occult outer retinopathy. J. Clin. Microbiol. 46, 130-135 (2008)).

To carry out this investigation the researchers analyzed blood samples looking for antibodies against yeasts, as well as different fungal components such as proteins and DNA. These results indicate the existence of a disseminated mycosis in most of the analyzed patients which suggests that retinopathies like AZOOR and Serpiginous choroiditis are caused by fungal infections. Looking for treatments based on current anti fungal drugs could offer great benefits for these patients. The clinical studies about the effects of anti fungal compounds in the evolution of these patients will be crucial to determine whether the presence of mycosis is the cause of the loss of visual acuity.

Future investigations by Dr. Luis Carrasco's research group will lean towards the improvement of diagnosis techniques for fungal infections and the cause of other retinopathies. These techniques will also be useful for the analysis of the evolution and effectiveness of the possible anti fungal treatments that are implemented with these patients.

Oficina de Cultura Científica | alfa
Further information:
http://dx.doi.org/10.1128/JCM.02605-06
http://www.uam.es

More articles from Health and Medicine:

nachricht Study tracks inner workings of the brain with new biosensor
16.08.2018 | Rheinische Friedrich-Wilhelms-Universität Bonn

nachricht Foods of the future
15.08.2018 | Georg-August-Universität Göttingen

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Color effects from transparent 3D-printed nanostructures

New design tool automatically creates nanostructure 3D-print templates for user-given colors
Scientists present work at prestigious SIGGRAPH conference

Most of the objects we see are colored by pigments, but using pigments has disadvantages: such colors can fade, industrial pigments are often toxic, and...

Im Focus: Unraveling the nature of 'whistlers' from space in the lab

A new study sheds light on how ultralow frequency radio waves and plasmas interact

Scientists at the University of California, Los Angeles present new research on a curious cosmic phenomenon known as "whistlers" -- very low frequency packets...

Im Focus: New interactive machine learning tool makes car designs more aerodynamic

Scientists develop first tool to use machine learning methods to compute flow around interactively designable 3D objects. Tool will be presented at this year’s prestigious SIGGRAPH conference.

When engineers or designers want to test the aerodynamic properties of the newly designed shape of a car, airplane, or other object, they would normally model...

Im Focus: Robots as 'pump attendants': TU Graz develops robot-controlled rapid charging system for e-vehicles

Researchers from TU Graz and their industry partners have unveiled a world first: the prototype of a robot-controlled, high-speed combined charging system (CCS) for electric vehicles that enables series charging of cars in various parking positions.

Global demand for electric vehicles is forecast to rise sharply: by 2025, the number of new vehicle registrations is expected to reach 25 million per year....

Im Focus: The “TRiC” to folding actin

Proteins must be folded correctly to fulfill their molecular functions in cells. Molecular assistants called chaperones help proteins exploit their inbuilt folding potential and reach the correct three-dimensional structure. Researchers at the Max Planck Institute of Biochemistry (MPIB) have demonstrated that actin, the most abundant protein in higher developed cells, does not have the inbuilt potential to fold and instead requires special assistance to fold into its active state. The chaperone TRiC uses a previously undescribed mechanism to perform actin folding. The study was recently published in the journal Cell.

Actin is the most abundant protein in highly developed cells and has diverse functions in processes like cell stabilization, cell division and muscle...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

LaserForum 2018 deals with 3D production of components

17.08.2018 | Event News

Within reach of the Universe

08.08.2018 | Event News

A journey through the history of microscopy – new exhibition opens at the MDC

27.07.2018 | Event News

 
Latest News

Smallest transistor worldwide switches current with a single atom in solid electrolyte

17.08.2018 | Physics and Astronomy

Robots as Tools and Partners in Rehabilitation

17.08.2018 | Information Technology

Climate Impact Research in Hannover: Small Plants against Large Waves

17.08.2018 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>