Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

LGC licenses Orchid to test for drug metabolising gene

10.06.2002


LGC, the UK`s leading independent provider of genetic testing services, has issued its first testing licence for the key DNA variant in the drug metabolising gene CYP2D6 to Orchid BioSciences Inc. LGC holds the exclusive commercialisation rights to the patented diagnosis of this `poor metaboliser` gene variation and, in granting this first licence, will make access to this beneficial technology available to leading companies internationally for the first time.



The gene CYP2D6 controls an enzyme in the human liver. About 6% of the Caucasian population have a genetically pre-determined deficiency in this enzyme. This means that they do not metabolise about 20% of currently prescribed medications correctly. The genetic variation in the gene CYP2D6, known as *4, was first invented by Imperial Cancer Research Fund (ICRF) scientists and patented by the Fund in the early 1990s. One of the inventors, Professor Roland Wolf, joined the University of Dundee and ICRF granted the University an exclusive licence. Subsequently, the University granted exclusive rights to LGC to commercialise and sub-license the technology in September 2001.

Dr Paul Debenham, Director of Life Sciences at LGC, and who has found himself to have the poor metaboliser gene status, said: "There is tremendous excitement in the field of genetically pre-determined drug metabolism, known as pharmacogenetics, about the growing understanding of how each individual may differ in their ability to respond to various medications, and in particular to avoid serious adverse reactions. This is an exciting start to the expansion of the opportunity for the public at large to benefit from understanding their own capability to respond to prescribed medications."


The first sub-licensee, Orchid BioSciences Inc, has taken a non-exclusive licence for North America for an undisclosed sum, and the gene diagnostic will be an essential element in their Orchid GeneShield business focused on pharmacogenomics and personalised medicine. Product offerings being developed by the Orchid GeneShield business are designed to enable physicians, patients and health care providers to better match the right drug to the right patient. LGC is also in discussions with other companies to respond to their interests in licensing and developing tests built around the *4 genetic test.

Dr Richard Worswick, LGC`s Chief Executive, said: "We foresee this as the first of many licensing deals and the forerunner of tremendous growth in the pharmacogenetics business sector. We are most pleased to have completed this non-exclusive agreement with Orchid BioSciences for North America."

Imelda Topping | alfa
Further information:
http://www.lgc.co.uk/news_story.asp?strareano=47_2&intelement=4234

More articles from Health and Medicine:

nachricht The genes are not to blame
20.07.2018 | Technische Universität München

nachricht Targeting headaches and tumors with nano-submarines
20.07.2018 | Universitätsmedizin der Johannes Gutenberg-Universität Mainz

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Future electronic components to be printed like newspapers

A new manufacturing technique uses a process similar to newspaper printing to form smoother and more flexible metals for making ultrafast electronic devices.

The low-cost process, developed by Purdue University researchers, combines tools already used in industry for manufacturing metals on a large scale, but uses...

Im Focus: First evidence on the source of extragalactic particles

For the first time ever, scientists have determined the cosmic origin of highest-energy neutrinos. A research group led by IceCube scientist Elisa Resconi, spokesperson of the Collaborative Research Center SFB1258 at the Technical University of Munich (TUM), provides an important piece of evidence that the particles detected by the IceCube neutrino telescope at the South Pole originate from a galaxy four billion light-years away from Earth.

To rule out other origins with certainty, the team led by neutrino physicist Elisa Resconi from the Technical University of Munich and multi-wavelength...

Im Focus: Magnetic vortices: Two independent magnetic skyrmion phases discovered in a single material

For the first time a team of researchers have discovered two different phases of magnetic skyrmions in a single material. Physicists of the Technical Universities of Munich and Dresden and the University of Cologne can now better study and understand the properties of these magnetic structures, which are important for both basic research and applications.

Whirlpools are an everyday experience in a bath tub: When the water is drained a circular vortex is formed. Typically, such whirls are rather stable. Similar...

Im Focus: Breaking the bond: To take part or not?

Physicists working with Roland Wester at the University of Innsbruck have investigated if and how chemical reactions can be influenced by targeted vibrational excitation of the reactants. They were able to demonstrate that excitation with a laser beam does not affect the efficiency of a chemical exchange reaction and that the excited molecular group acts only as a spectator in the reaction.

A frequently used reaction in organic chemistry is nucleophilic substitution. It plays, for example, an important role in in the synthesis of new chemical...

Im Focus: New 2D Spectroscopy Methods

Optical spectroscopy allows investigating the energy structure and dynamic properties of complex quantum systems. Researchers from the University of Würzburg present two new approaches of coherent two-dimensional spectroscopy.

"Put an excitation into the system and observe how it evolves." According to physicist Professor Tobias Brixner, this is the credo of optical spectroscopy....

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Leading experts in Diabetes, Metabolism and Biomedical Engineering discuss Precision Medicine

13.07.2018 | Event News

Conference on Laser Polishing – LaP: Fine Tuning for Surfaces

12.07.2018 | Event News

11th European Wood-based Panel Symposium 2018: Meeting point for the wood-based materials industry

03.07.2018 | Event News

 
Latest News

A smart safe rechargeable zinc ion battery based on sol-gel transition electrolytes

20.07.2018 | Power and Electrical Engineering

Reversing cause and effect is no trouble for quantum computers

20.07.2018 | Information Technology

Princeton-UPenn research team finds physics treasure hidden in a wallpaper pattern

20.07.2018 | Materials Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>