A research team directed by Professor Göran Roos at the Department of Medical Bioscience, Pathology, is behind the study, which is now being published in the journal Blood.
The study, carried out in collaboration with colleagues at Ulm University, Germany, and at Uppsala University, Sweden, shows that the length of telomeres in chronic lymphatic leukemia (CLL) cells is tied to specific genetic aberrations of known prognostic significance.
Cases with no chromosome 17p or 11q evinced short telomeres, while cases with no 13q had significantly longer telomeres. Other known prognostic factors, such as the number of mutations in immunoglobulin genes, expression of the proteins ZAP70 and CD38, and clinical stage, were all significantly associated with telomere length as well. It was interesting that telomere length proved to be a prognostic marker that is independent of all of these factors. In other words, it can tell us more about the future prospects of leukemia patients than previously known markers are able to.
The tips of chromosomes, telomeres, are important for the genetic stability of our cells. In normal cells, telomeres are shortened each time the cell divides, whereas cancer cells usually have stable telomere length. This stability helps lend cancer cells 'eternal' life. The telomere length of a cell is determined by a balance between positive and negative factors, many of which are unknown. Short telomeres have been shown to be tied to unstable genes. This research team has previously demonstrated that patients with CLL where the leukemia cells evince short telomeres (reduced median length) have a significantly poorer prognosis than patients with long telomeres (Grabowski et al. 2005; Blood, 105(12):4807-12).
For more information, please contact Professor Göran Roos, Department of Medical Bioscience, Section for Pathology, phone: +46 (0)90-785 18 01, e-mail email@example.com.A high-resolution picture of Göran Roos can be downloaded from
Commentary: Lin TS. Do short telomeres shorten CLL survival? Blood, 15 February 2008, Vol. 111, No. 4, pp. 1755.
Bertil Born | Umeå University
Microgel powder fights infection and helps wounds heal
14.11.2018 | Michigan Technological University
Spread of deadly eye cancer halted in cells and animals
13.11.2018 | Johns Hopkins Medicine
Biochips have been developed at TU Wien (Vienna), on which tissue can be produced and examined. This allows supplying the tissue with different substances in a very controlled way.
Cultivating human cells in the Petri dish is not a big challenge today. Producing artificial tissue, however, permeated by fine blood vessels, is a much more...
Faster and secure data communication: This is the goal of a new joint project involving physicists from the University of Würzburg. The German Federal Ministry of Education and Research funds the project with 14.8 million euro.
In our digital world data security and secure communication are becoming more and more important. Quantum communication is a promising approach to achieve...
On Saturday, 10 November 2018, the research icebreaker Polarstern will leave its homeport of Bremerhaven, bound for Cape Town, South Africa.
When choosing materials to make something, trade-offs need to be made between a host of properties, such as thickness, stiffness and weight. Depending on the application in question, finding just the right balance is the difference between success and failure
Now, a team of Penn Engineers has demonstrated a new material they call "nanocardboard," an ultrathin equivalent of corrugated paper cardboard. A square...
Physicists at ETH Zurich demonstrate how errors that occur during the manipulation of quantum system can be monitored and corrected on the fly
The field of quantum computation has seen tremendous progress in recent years. Bit by bit, quantum devices start to challenge conventional computers, at least...
09.11.2018 | Event News
06.11.2018 | Event News
23.10.2018 | Event News
14.11.2018 | Materials Sciences
14.11.2018 | Health and Medicine
14.11.2018 | Life Sciences