Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Online tool supports more dialogue on prostate cancer risk

05.02.2008
Validated nomogram tool can identify normal PSA level patients at risk for aggressive prostate cancer and has been shown to perform better than conventional screening

A comprehensive, clinical nomogram tool, the Sunnybrook Prostate Cancer Risk Calculator – the first to use all known risk factors for prostate cancer – is available online to help men determine individual prostate cancer risk in consultation with their primary care physician. A nomogram is a statistical model to determine risk for disease based on risk factors using a table and chart format.

"This tool facilitates proactive dialogue between patients and their primary care physicians about prostate cancer risk, and management and treatment options," says Dr. Robert Nam, lead investigator and urologic oncologist, Odette Cancer Centre, Sunnybrook. “In addition to helping men avoid unnecessary biopsies this nomogram better detects prostate cancer at an earlier more curable stage and helps identify high risk patients who may need to make immediate dietary and lifestyle changes and need repeat biopsies.”

Sunnybrook researchers developed and validated the nomogram with 3,108 Canadian men including a subset of 408 volunteers with normal PSA (prostate specific antigen) levels who underwent a prostate biopsy. Of the 3,108 men, 42 per cent were diagnosed with prostate cancer. The nomogram was shown to perform better than conventional screening with PSA and DRE (digital rectal exam) alone, especially for patients with a known normal PSA level. Among the 408 men with a normal PSA, 24 per cent were diagnosed with prostate cancer. Further evaluation of the nomogram is underway with a multi-institutional, cross-Canada study group of another 5,000 men.

At age 70, Colin Graham’s PSA level was considered normal (less than or equal to 4.0 ng/ML). When the nomogram was used to assess all his risk factors, Dr. Nam recommended a prostate biopsy. The biopsy diagnosed aggressive prostate cancer and Colin underwent immediate and successful treatment through surgery. "I can’t express enough the relief I felt, knowing things were caught in time," says Graham, "and though this cancer was removed successfully, because I know my risk, I’m also aware I still need to be monitored."

"In Colin’s case, though his PSA was normal, a biopsy was justified based on the nomogram. On the other hand, in the case of an older patient with a high PSA level, if the nomogram predicts a low chance of having aggressive prostate cancer, then it would be reasonable to forego a biopsy," says Dr. Nam, assistant professor, department of surgery, University of Toronto.

Unlike current prostate cancer nomograms, this nomogram evaluates the risk of having prostate cancer in patients undergoing PSA screening. Known risk factors and tumour markers used are age, family, history of prostate cancer, ethnicity, urinary symptoms, PSA, free:total PSA ratio, and DRE (performed by the primary care physician). The Sunnybrook Prostate Cancer Risk Calculator is best used in collaboration with an individual’s primary care physician. If a patient determines he is at risk for aggressive prostate cancer, he can discuss management and treatment options in consultation with his primary care physician.

Natalie Chung-Sayers | EurekAlert!
Further information:
http://www.sunnybrook.ca/programs/occ/prostaterisk/nomogram
http://www.sunnybrook.ca

More articles from Health and Medicine:

nachricht Shipment tracking for "fat parcels" in the body
14.10.2019 | Rheinische Friedrich-Wilhelms-Universität Bonn

nachricht Antibody-based eye drops show promise for treating dry eye disease
14.10.2019 | University of Illinois at Chicago

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Novel Material for Shipbuilding

A new research project at the TH Mittelhessen focusses on the development of a novel light weight design concept for leisure boats and yachts. Professor Stephan Marzi from the THM Institute of Mechanics and Materials collaborates with Krake Catamarane, which is a shipyard located in Apolda, Thuringia.

The project is set up in an international cooperation with Professor Anders Biel from Karlstad University in Sweden and the Swedish company Lamera from...

Im Focus: Controlling superconducting regions within an exotic metal

Superconductivity has fascinated scientists for many years since it offers the potential to revolutionize current technologies. Materials only become superconductors - meaning that electrons can travel in them with no resistance - at very low temperatures. These days, this unique zero resistance superconductivity is commonly found in a number of technologies, such as magnetic resonance imaging (MRI).

Future technologies, however, will harness the total synchrony of electronic behavior in superconductors - a property called the phase. There is currently a...

Im Focus: How Do the Strongest Magnets in the Universe Form?

How do some neutron stars become the strongest magnets in the Universe? A German-British team of astrophysicists has found a possible answer to the question of how these so-called magnetars form. Researchers from Heidelberg, Garching, and Oxford used large computer simulations to demonstrate how the merger of two stars creates strong magnetic fields. If such stars explode in supernovae, magnetars could result.

How Do the Strongest Magnets in the Universe Form?

Im Focus: Liquifying a rocky exoplanet

A hot, molten Earth would be around 5% larger than its solid counterpart. This is the result of a study led by researchers at the University of Bern. The difference between molten and solid rocky planets is important for the search of Earth-like worlds beyond our Solar System and the understanding of Earth itself.

Rocky exoplanets that are around Earth-size are comparatively small, which makes them incredibly difficult to detect and characterise using telescopes. What...

Im Focus: Axion particle spotted in solid-state crystal

Scientists at the Max Planck Institute for Chemical Physics of Solids in Dresden, Princeton University, the University of Illinois at Urbana-Champaign, and the University of the Chinese Academy of Sciences have spotted a famously elusive particle: The axion – first predicted 42 years ago as an elementary particle in extensions of the standard model of particle physics.

The team found signatures of axion particles composed of Weyl-type electrons (Weyl fermions) in the correlated Weyl semimetal (TaSe₄)₂I. At room temperature,...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

International Symposium on Functional Materials for Electrolysis, Fuel Cells and Metal-Air Batteries

02.10.2019 | Event News

NEXUS 2020: Relationships Between Architecture and Mathematics

02.10.2019 | Event News

Optical Technologies: International Symposium „Future Optics“ in Hannover

19.09.2019 | Event News

 
Latest News

How to control friction in topological insulators

14.10.2019 | Physics and Astronomy

The shelf life of pyrite

14.10.2019 | Earth Sciences

Shipment tracking for "fat parcels" in the body

14.10.2019 | Health and Medicine

VideoLinks
Science & Research
Overview of more VideoLinks >>>