Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Pediatricians Call for a Cohesive Definition of Metabolic Syndrome in Children

11.01.2008
Metabolic syndrome in children represents a potentially serious threat to health in adulthood, yet many parents and caregivers do not have a clear idea of what metabolic syndrome is and why it is dangerous.

Metabolic syndrome is a group of cardiovascular risk factors, including obesity, hypertension, prediabetes, and reduced HDL (“good”) cholesterol. Because it is difficult to know when a child is at risk for metabolic syndrome, some doctors fear that children may not be properly diagnosed as a result. The February 2008 issue of The Journal of Pediatrics focuses on this issue by publishing a series of articles in an attempt to work toward a cohesive definition of metabolic syndrome in children.

Five articles of the series were completed by researchers from the Pediatric Metabolic Syndrome Working Group (PMSWG), a team of researchers from various institutions across the United States. The members of the PMSWG explored the potential for a unified and cohesive definition for metabolic syndrome. The researchers evaluated how current definitions relate to the number of children diagnosed with metabolic syndrome. They found that because of the variety of definitions used by pediatricians, it is difficult to estimate the prevalence of the syndrome among children and adolescents. Additionally, the researchers looked at how well each metabolic risk factor predicts future health issues. According to Dr. Terry Huang, “these papers represent summaries of the current state of knowledge for factors related to metabolic syndrome.” By gathering this information, the PMSWG hopes to provide a frame of reference for pediatricians working with metabolic syndrome.

Dr. John Morrison and colleagues from Cincinnati Children’s Medical Center, Cincinnati Jewish Hospital, and Maryland Medical Research Institute collected data from a 25-30 year study concerning cardiovascular risk factors. They found that metabolic syndrome in children may have a direct link to type 2 diabetes in adulthood.

In a related article, Dr. Claudio Maffeis and colleagues from The Obesity Study Group of the Italian Society of Pediatric Endocrinology and Diabetology used body mass index (BMI), waist circumference, and weight to height ratios to determine obesity in a group of 974 children. They found that evaluating waist circumference and weight to height ratio measurements may be more accurate in determining metabolic risk than using body mass index alone.

These articles demonstrate that symptoms of adult metabolic syndrome begin in childhood and may be directly related to obesity. They also illustrate the need for a clear definition of metabolic syndrome in children. According to Dr. Reginald Washington, “once this definition exists, medical providers who care for children will know what to look for in order to identify children who are at risk to develop adult metabolic syndrome.” Such a definition could lead to better treatment of childhood metabolic syndrome, which could positively impact the growing obesity epidemic.

These studies are reported in the following:
•“Finding Thresholds of Risk for Components of the Pediatric Metabolic Syndrome”, by Terry T-K Huang, PhD, MPH

•“Metabolic Syndrome Rates in United States Adolescents, from the National Health and Nutrition Examination Survey, 1999-2002” by Stephen Cook, MD, Peggy Auinger, MS, Chaoyang Li, MD, PhD, and Earl S. Ford, MD, MPH

•“Examining Metabolic Syndrome Definitions in Overweight Hispanic Youth: A Focus on Insulin Resistance” by Gabriel Q. Shaibi, PhD, PT, and Michael I. Goran, PhD

•“Comparison of Different Definitions of Pediatric Metabolic Syndrome: Relation to Abdominal Adiposity, Insulin Resistance, Adiponectin, and Inflammatory Biomarkers” by SoJung Lee, PhD, Fida Bacha, MD, Neslihan Gungor, MD, and Silva Arslanian, MD

•“Defining the Metabolic Syndrome in Children and Adolescents: Will the Real Definition Please Stand Up?” by Earl S. Ford, MD, MPH, and Chaoyang Li, MD, PhD

•“Sensitivity, Specificity, and Predictive Values of Pediatric Metabolic Syndrome Components in Relation to Adult Metabolic Syndrome: The Princeton LRC Follow-up Study” by Terry T-K Huang, PhD, MPH, Tonya R. Nansel, PhD, Allen R. Belsheim, MA, and John A. Morrison, PhD

•“Childhood Obesity Predicts Adult Metabolic Syndrome: The Fels Longitudinal Study” by Shumei S. Sun, PhD, Ruohong Liang, MS, Terry T-K Huang, PhD, MPH, Stephen R. Daniels, MD, PhD, Silva Arslanian, MD, Kiang Liu, PhD, Gilman D. Grave, MD, and Roger M. Siervogel, PhD

•“Metabolic Syndrome in Childhood Predicts Adult Metabolic Syndrome and Type 2 Diabetes Mellitus 25 to 30 Years Later” by John A. Morrison, PhD, Lisa Aronson Friedman, ScM, Ping Wang, PhD, and Charles J. Glueck, MD

•“Waist-to-Height Ratio, a Useful Index to Identify High Metabolic Risk in Overweight Children” by Claudio Maffeis, MD, Claudia Banzato, MD, and Giorgio Talamini, MD, on behalf of The Obesity Study Group of The Italian Society of Pediatric Endocrinology and Diabetology.

The articles appear in The Journal of Pediatrics, Volume 152 Number 2 (February 2008), published by Elsevier.

Brigid Huey | alfa
Further information:
http://www.elsevier.com

More articles from Health and Medicine:

nachricht UIC researchers find unique organ-specific signature profiles for blood vessel cells
18.02.2020 | University of Illinois at Chicago

nachricht Remdesivir prevents MERS coronavirus disease in monkeys
14.02.2020 | NIH/National Institute of Allergy and Infectious Diseases

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Freiburg researcher investigate the origins of surface texture

Most natural and artificial surfaces are rough: metals and even glasses that appear smooth to the naked eye can look like jagged mountain ranges under the microscope. There is currently no uniform theory about the origin of this roughness despite it being observed on all scales, from the atomic to the tectonic. Scientists suspect that the rough surface is formed by irreversible plastic deformation that occurs in many processes of mechanical machining of components such as milling.

Prof. Dr. Lars Pastewka from the Simulation group at the Department of Microsystems Engineering at the University of Freiburg and his team have simulated such...

Im Focus: Skyrmions like it hot: Spin structures are controllable even at high temperatures

Investigation of the temperature dependence of the skyrmion Hall effect reveals further insights into possible new data storage devices

The joint research project of Johannes Gutenberg University Mainz (JGU) and the Massachusetts Institute of Technology (MIT) that had previously demonstrated...

Im Focus: Making the internet more energy efficient through systemic optimization

Researchers at Chalmers University of Technology, Sweden, recently completed a 5-year research project looking at how to make fibre optic communications systems more energy efficient. Among their proposals are smart, error-correcting data chip circuits, which they refined to be 10 times less energy consumptive. The project has yielded several scientific articles, in publications including Nature Communications.

Streaming films and music, scrolling through social media, and using cloud-based storage services are everyday activities now.

Im Focus: New synthesis methods enhance 3D chemical space for drug discovery

After helping develop a new approach for organic synthesis -- carbon-hydrogen functionalization -- scientists at Emory University are now showing how this approach may apply to drug discovery. Nature Catalysis published their most recent work -- a streamlined process for making a three-dimensional scaffold of keen interest to the pharmaceutical industry.

"Our tools open up whole new chemical space for potential drug targets," says Huw Davies, Emory professor of organic chemistry and senior author of the paper.

Im Focus: Quantum fluctuations sustain the record superconductor

Superconductivity approaching room temperature may be possible in hydrogen-rich compounds at much lower pressures than previously expected

Reaching room-temperature superconductivity is one of the biggest dreams in physics. Its discovery would bring a technological revolution by providing...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

70th Lindau Nobel Laureate Meeting: Around 70 Laureates set to meet with young scientists from approx. 100 countries

12.02.2020 | Event News

11th Advanced Battery Power Conference, March 24-25, 2020 in Münster/Germany

16.01.2020 | Event News

Laser Colloquium Hydrogen LKH2: fast and reliable fuel cell manufacturing

15.01.2020 | Event News

 
Latest News

Movement of a liquid droplet generates over 5 volts of electricity

18.02.2020 | Power and Electrical Engineering

Powering the future: Smallest all-digital circuit opens doors to 5 nm next-gen semiconductor

18.02.2020 | Information Technology

Studying electrons, bridging two realms of physics: connecting solids and soft matter

18.02.2020 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>