New research by the Faculty of Kinesiology hopes to measure one of the syndrome’s most obvious symptoms — information that could help doctors in the diagnosis CFS.
“Diagnosis of the syndrome, generally follows eliminating every other possible cause, which leads some to speculate that the condition isn’t real,” says Dr. Brian MacIntosh. “One thing we know is that CFS sufferers feel profound fatigue and worsening of other symptoms following even moderate physical activity. Using our expertise in the field of exercise physiology we believe we can measure this post exertion malaise and say with certainty if an individual has recovered from exercise or if that activity is making them even more fatigued.”
MacIntosh, who is the Faculty of Kinesiology’s Associate Dean of Graduate Studies, is an expert in the area of muscle fatigue. Much of his research has centered on high-performance athletes in peak physical condition, however he says that this research fits in well with his overall area of interest.
“The tools we have developed in high performance sport are perfectly suited to track muscle fatigue in this application so without question we will be able to get some concrete answers,” he says.
The research trial will put CFS patients on a stationary bike to perform a VO2 Max test – similar to trials used to evaluate the fitness level of professional athletes. The individual will pedal to the point of fatigue, at which point researchers will take several measurements including a blood sample in which lactate will be quantified. The next day the patient will return and follow the same workout protocol.
“Most healthy individuals should be able to easily match their performance from the previous day,” MacIntosh explains. “Since CFS patients by definition report profound fatigue from even moderate physical exertion and take greater than 24 hours to recover, we would expect to see a decrease in their physical performance and we should be able to measure that in several ways.”
This work may shed some light on whether the fatigue experienced by people with CFS is primarily in the muscles or in the nervous system. MacIntosh believes that the results of this work could lead to a definitive diagnosis of CFS, giving another tool in the otherwise limited toolbox of diagnostic tests and perhaps, more importantly, shed some light on the broader issue of human muscle fatigue.
“We've all experienced fatigue in our lives," says MacIntosh. "For example when we have the flu or any similar illness, we feel that fatigue makes our arms and legs feel like they’re made of lead... I’m hoping that this research may lead to a greater understanding of human muscle fatigue in general.”
Why might reading make myopic?
18.07.2018 | Universitätsklinikum Tübingen
Unique brain 'fingerprint' can predict drug effectiveness
11.07.2018 | McGill University
For the first time ever, scientists have determined the cosmic origin of highest-energy neutrinos. A research group led by IceCube scientist Elisa Resconi, spokesperson of the Collaborative Research Center SFB1258 at the Technical University of Munich (TUM), provides an important piece of evidence that the particles detected by the IceCube neutrino telescope at the South Pole originate from a galaxy four billion light-years away from Earth.
To rule out other origins with certainty, the team led by neutrino physicist Elisa Resconi from the Technical University of Munich and multi-wavelength...
For the first time a team of researchers have discovered two different phases of magnetic skyrmions in a single material. Physicists of the Technical Universities of Munich and Dresden and the University of Cologne can now better study and understand the properties of these magnetic structures, which are important for both basic research and applications.
Whirlpools are an everyday experience in a bath tub: When the water is drained a circular vortex is formed. Typically, such whirls are rather stable. Similar...
Physicists working with Roland Wester at the University of Innsbruck have investigated if and how chemical reactions can be influenced by targeted vibrational excitation of the reactants. They were able to demonstrate that excitation with a laser beam does not affect the efficiency of a chemical exchange reaction and that the excited molecular group acts only as a spectator in the reaction.
A frequently used reaction in organic chemistry is nucleophilic substitution. It plays, for example, an important role in in the synthesis of new chemical...
Optical spectroscopy allows investigating the energy structure and dynamic properties of complex quantum systems. Researchers from the University of Würzburg present two new approaches of coherent two-dimensional spectroscopy.
"Put an excitation into the system and observe how it evolves." According to physicist Professor Tobias Brixner, this is the credo of optical spectroscopy....
Ultra-short, high-intensity X-ray flashes open the door to the foundations of chemical reactions. Free-electron lasers generate these kinds of pulses, but there is a catch: the pulses vary in duration and energy. An international research team has now presented a solution: Using a ring of 16 detectors and a circularly polarized laser beam, they can determine both factors with attosecond accuracy.
Free-electron lasers (FELs) generate extremely short and intense X-ray flashes. Researchers can use these flashes to resolve structures with diameters on the...
13.07.2018 | Event News
12.07.2018 | Event News
03.07.2018 | Event News
18.07.2018 | Materials Sciences
18.07.2018 | Life Sciences
18.07.2018 | Health and Medicine