Dehydration occurs when the body does not have enough water and this can happen rapidly in extreme heat or through exercise. Symptoms of dehydration can include headaches, lethargy and hallucinations. In extreme cases, dehydration may result in death.
Florey researchers Dr Michael Farrell, A/Prof Gary Egan and Prof Derek Denton discovered that a region in the brain called the mid cingulate cortex predicts how much water a person needs, but this region malfunctions in older people.
Dr Farrell said they infused old (age 65 to 74) and young (age 21 to 30) research participants with salty water to make them thirsty and then allowed them to drink as much water as they wanted.
“Although all participants had the same level of thirst, the older people only drank half as much water as the younger subjects,” Dr Farrell said.
“Using PET imaging we found in the older people, the mid cingulate cortex was ‘turned off’ much earlier by drinking small volumes.”
“This discovery helps explain why the elderly can become easily dehydrated,” he said.
The August 2003 European heatwave claimed around 52,000 lives through dehydration and other causes* – many of these were older people. France suffered the worst losses, with 14,802 people dying from the heatwave.
As climate change continues to be a hot global issue, the health implications for the elderly from rising summer temperatures add to this concern.
Dr Farrell recommended that older people ensure they drink enough water during hot weather.
“Adults should drink about eight glasses of water per day to prevent dehydration, and physically active people may need to drink more,” Dr Farrell said.
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Researchers from the Department of Atomically Resolved Dynamics of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg, the University of Hamburg and the European Molecular Biology Laboratory (EMBL) outstation in the city have developed a new method to watch biomolecules at work. This method dramatically simplifies starting enzymatic reactions by mixing a cocktail of small amounts of liquids with protein crystals. Determination of the protein structures at different times after mixing can be assembled into a time-lapse sequence that shows the molecular foundations of biology.
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Researchers from the Department of Atomically Resolved Dynamics of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg, the University of Potsdam (both in Germany) and the University of Toronto (Canada) have pieced together a detailed time-lapse movie revealing all the major steps during the catalytic cycle of an enzyme. Surprisingly, the communication between the protein units is accomplished via a water-network akin to a string telephone. This communication is aligned with a ‘breathing’ motion, that is the expansion and contraction of the protein.
This time-lapse sequence of structures reveals dynamic motions as a fundamental element in the molecular foundations of biology.
Two research teams have succeeded simultaneously in measuring the long-sought Thorium nuclear transition, which enables extremely precise nuclear clocks. TU Wien (Vienna) is part of both teams.
If you want to build the most accurate clock in the world, you need something that "ticks" very fast and extremely precise. In an atomic clock, electrons are...
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