The novel approach that will be tested in the routine diagnosis of lymphoma in the Department of Pathology is based on a new biomarker, i.e., a factor that is specific for a certain disease. The discovery is a result of research within CREATE Health, a Center for Translational Cancer Research supported by the Foundation for Strategic Research and the Wallenberg Foundation.
CREATE Health has integrated investigators from the faculties of medicine, engineering, and natural sciences together with clinical oncologists from the university hospital. The overall aim is to identify proteins and genes that can be used as biomarkers for cancer, using emerging advanced technologies. Several very promising projects are under development, but the novel diagnostic approach for MCL has advanced the furthest. Scientist Sara Ek and colleagues have by studying more than 50,000 gene fragments found those that are specifically overexpressed in this disease. She has also identified the corresponding proteins and it is one of these proteins that serves as a specific biomarker.
- In a collaboration with pathologists, we are now studying the biomarker to see if it can be used as a novel routine test for this aggressive blood cancer. In a longer perspective, knowledge about the function of these disease-specific proteins can also lead to novel therapeutic modalities for blood cancer, explains professor Carl Borrebaeck, program director for CREATE Health.Dr. Michael Dictor, pathologist at Lund University Hospital agrees.
Ingela Bjoerck | alfa
Study tracks inner workings of the brain with new biosensor
16.08.2018 | Rheinische Friedrich-Wilhelms-Universität Bonn
Foods of the future
15.08.2018 | Georg-August-Universität Göttingen
New design tool automatically creates nanostructure 3D-print templates for user-given colors
Scientists present work at prestigious SIGGRAPH conference
Most of the objects we see are colored by pigments, but using pigments has disadvantages: such colors can fade, industrial pigments are often toxic, and...
Scientists at the University of California, Los Angeles present new research on a curious cosmic phenomenon known as "whistlers" -- very low frequency packets...
Scientists develop first tool to use machine learning methods to compute flow around interactively designable 3D objects. Tool will be presented at this year’s prestigious SIGGRAPH conference.
When engineers or designers want to test the aerodynamic properties of the newly designed shape of a car, airplane, or other object, they would normally model...
Researchers from TU Graz and their industry partners have unveiled a world first: the prototype of a robot-controlled, high-speed combined charging system (CCS) for electric vehicles that enables series charging of cars in various parking positions.
Global demand for electric vehicles is forecast to rise sharply: by 2025, the number of new vehicle registrations is expected to reach 25 million per year....
Proteins must be folded correctly to fulfill their molecular functions in cells. Molecular assistants called chaperones help proteins exploit their inbuilt folding potential and reach the correct three-dimensional structure. Researchers at the Max Planck Institute of Biochemistry (MPIB) have demonstrated that actin, the most abundant protein in higher developed cells, does not have the inbuilt potential to fold and instead requires special assistance to fold into its active state. The chaperone TRiC uses a previously undescribed mechanism to perform actin folding. The study was recently published in the journal Cell.
Actin is the most abundant protein in highly developed cells and has diverse functions in processes like cell stabilization, cell division and muscle...
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