Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Rapid, point-of-care tests for syphilis: The future of diagnosis

28.02.2013
Syphilis is on the rise worldwide and there is an urgent need for reliable and rapid screening, particularly for people who live in areas where access to healthcare is limited.

An international research team, led by scientists at the Research Institute of the McGill University Health Centre (RI-MUHC) in Montreal, has demonstrated that rapid and point-of-care tests (POC) for syphilis are as accurate as conventional laboratory tests. The findings, which were published in PLoS ONE, call for a major change in approach to syphilis testing and recommend replacing first line laboratory tests with POC tests globally, especially in resource-limited settings.

"There is a need to embrace rapid and POC tests for syphilis in global settings," argues Dr. Nitika Pant Pai, the study's senior and corresponding author, clinical researcher at the RI-MUHC and assistant professor in the Department of Medicine at McGill University. "This meta-analysis generates global evidence across all populations for POC tests for syphilis and is the first to use sophisticated analyses to explore the accuracy of POC tests compared to the best reference standards."

Currently, syphilis is screened using conventional laboratory-based tests that can take up to three weeks to deliver results. These tests require chemical agents, trained staff and a continuous supply of electricity, which are not readily available in some parts of the world. Rapid and POC tests can be performed on a simple finger stick sample one patient at a time, and the results communicated to the patient within 20 minutes, saving time and helping doctors order confirmatory tests and rapidly flagging patients who need treatment.

Syphilis is a sexually transmitted disease caused by the rod-like bacterium Treponema pallidum. It is transmitted between sexual partners through direct contact with a Syphilis sore. It may also be transmitted from mother to foetus during pregnancy or at birth, resulting in congenital syphilis. "As well timely screening and treatment in first trimester is extremely important for pregnant women to prevent still births, pre-term births and mother-to-child transmission of syphilis," adds Yalda Jafari, the study's first author and a former master's student of Dr. Pant Pai.

As many as 50 million people worldwide are being treated for syphilis and about 12 million new cases are diagnosed every year. However, approximately 90% of those infected do not know it, and this is the driving force behind the worldwide epidemic. The U.S. Centers for Disease Control (CDC) often refers to syphilis as the "great imitator," because many of its symptoms are similar to other diseases.

"Our study has major worldwide implications for populations living in rural areas with limited access to healthcare," says Dr. Pant Pai. "These tests offer the potential to expedite first line screening in settings where people have no access to a primary care physician or where laboratories take more than a week to deliver results."

About this study

The study entitled "Are Treponema pallidum Specific Rapid and Point-of-Care Tests for Syphilis Accurate Enough for Screening in Resource Limited Settings? Evidence from a Meta-Analysis", was coauthored by Yalda Jafari (Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Canada); Rosanna W. Peeling (London School of Hygiene and Tropical Medicine, UK); Sushmita Shivkumar (Clinical Epidemiology and McGill University , Canada); Christiane Claessens (Institut national de santé publique, Canada); Lawrence Joseph (Division of Clinical Epidemiology, Department of Medicine, McGill University/RI-MUHC and Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Canada); and Nitika Pant Pai (Division of Clinical Epidemiology, Department of Medicine, McGill University and RI-MUHC, Canada).

This work was funded by a grant from the Canadian Institutes of Health Research (CIHR).

Click on the link below to access the PDF: http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0054695

Useful links

PLoS ONE: plosone.org
McGill University Health Centre (MUHC): muhc.ca
Research Institute of the MUHC (RI-MUHC): muhc.ca/research
McGill University: mcgill.ca
Media
Julie Robert
Communications – Research
Public Affairs & Strategic Planning
McGill University Health Centre
Phone: 514-934-1934 (ext. 71381)
julie.robert@muhc.mcgill.ca

Julie Robert | EurekAlert!
Further information:
http://www.muhc.mcgill.ca

More articles from Health and Medicine:

nachricht Why might reading make myopic?
18.07.2018 | Universitätsklinikum Tübingen

nachricht Unique brain 'fingerprint' can predict drug effectiveness
11.07.2018 | McGill University

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: First evidence on the source of extragalactic particles

For the first time ever, scientists have determined the cosmic origin of highest-energy neutrinos. A research group led by IceCube scientist Elisa Resconi, spokesperson of the Collaborative Research Center SFB1258 at the Technical University of Munich (TUM), provides an important piece of evidence that the particles detected by the IceCube neutrino telescope at the South Pole originate from a galaxy four billion light-years away from Earth.

To rule out other origins with certainty, the team led by neutrino physicist Elisa Resconi from the Technical University of Munich and multi-wavelength...

Im Focus: Magnetic vortices: Two independent magnetic skyrmion phases discovered in a single material

For the first time a team of researchers have discovered two different phases of magnetic skyrmions in a single material. Physicists of the Technical Universities of Munich and Dresden and the University of Cologne can now better study and understand the properties of these magnetic structures, which are important for both basic research and applications.

Whirlpools are an everyday experience in a bath tub: When the water is drained a circular vortex is formed. Typically, such whirls are rather stable. Similar...

Im Focus: Breaking the bond: To take part or not?

Physicists working with Roland Wester at the University of Innsbruck have investigated if and how chemical reactions can be influenced by targeted vibrational excitation of the reactants. They were able to demonstrate that excitation with a laser beam does not affect the efficiency of a chemical exchange reaction and that the excited molecular group acts only as a spectator in the reaction.

A frequently used reaction in organic chemistry is nucleophilic substitution. It plays, for example, an important role in in the synthesis of new chemical...

Im Focus: New 2D Spectroscopy Methods

Optical spectroscopy allows investigating the energy structure and dynamic properties of complex quantum systems. Researchers from the University of Würzburg present two new approaches of coherent two-dimensional spectroscopy.

"Put an excitation into the system and observe how it evolves." According to physicist Professor Tobias Brixner, this is the credo of optical spectroscopy....

Im Focus: Chemical reactions in the light of ultrashort X-ray pulses from free-electron lasers

Ultra-short, high-intensity X-ray flashes open the door to the foundations of chemical reactions. Free-electron lasers generate these kinds of pulses, but there is a catch: the pulses vary in duration and energy. An international research team has now presented a solution: Using a ring of 16 detectors and a circularly polarized laser beam, they can determine both factors with attosecond accuracy.

Free-electron lasers (FELs) generate extremely short and intense X-ray flashes. Researchers can use these flashes to resolve structures with diameters on the...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Leading experts in Diabetes, Metabolism and Biomedical Engineering discuss Precision Medicine

13.07.2018 | Event News

Conference on Laser Polishing – LaP: Fine Tuning for Surfaces

12.07.2018 | Event News

11th European Wood-based Panel Symposium 2018: Meeting point for the wood-based materials industry

03.07.2018 | Event News

 
Latest News

Machine-learning predicted a superhard and high-energy-density tungsten nitride

18.07.2018 | Materials Sciences

NYSCF researchers develop novel bioengineering technique for personalized bone grafts

18.07.2018 | Life Sciences

Why might reading make myopic?

18.07.2018 | Health and Medicine

VideoLinks
Science & Research
Overview of more VideoLinks >>>