Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Purdue researchers developing novel biomedical imaging system

29.08.2018

System combines optical, ultrasound technology

Purdue University researchers are developing a novel biomedical imaging system that combines optical and ultrasound technology to improve diagnosis of life-threatening diseases.


Purdue University researchers are developing a novel biomedical imaging system that combines optical and ultrasound technology to improve diagnosis of life-threatening diseases. The researchers have created a motorized photoacoustic holder that allows users to easily maneuver the fiber optic bundles to tune the depth where light is focused, improving the light penetration depth and signal-to-noise ratio of the images.

Credit: Purdue Research Foundation Image

Photoacoustic tomography is a noninvasive technique that works by converting absorbed optical energy into acoustic signal. Pulsed light is sent into body tissue, creating a small increase in temperature that causes the tissue to expand and create an acoustic response that can be detected by an ultrasound transducer. The ultrasound data is used to visualize the tissue.

"The nice thing about photoacoustic tomography is the compositional information," said Craig Goergen, an assistant professor in Purdue's Weldon School of Biomedical Engineering. "It provides information about where blood and lipid are located, along with other essential information."

The ultimate goal is to enhance the clinical care of patients.

The results of a study describing an adjustable photoacoustic probe with improved light delivery and image quality were published Tuesday (Aug. 28) in the journal Photoacoustics.

The system provides real-time compositional information of body tissue without the need for contrast agents and with better depth penetration compared with conventional optical techniques.

Photoacoustic tomography can be used to detect or monitor a myriad of diseases, including cardiovascular disease, diabetes, and cancer. Those are diseases that the Centers for Disease Control and Prevention lists as among the most common, costly, and preventable of all health problems. Heart disease and cancer each account for one in every four deaths a year in the United States, and more than 30 million Americans, or more than 9 percent of the population, have diabetes. The cost of those three diseases a year in the United States is more than $718 billion a year, according to the CDC.

"That means there will be a great need for medical imaging. Trying to diagnose these diseases at an earlier time can lead to improved patient care," Goergen said. "We are in the process now of trying to use this enhanced imaging approach to a variety of different applications to see what it can be used for."

Among other potential uses for photoacoustic tomography is the mapping of lipid deposition within an arterial wall that can cause other health problems, measuring cardiac tissue damage and tumor biopsies. Using photoacoustic tomography for intraoperative tumor biopsies could help surgeons make sure they remove all the cancer from a patient, Goergen said.

One of the challenges of photoacoustic tomography is improving the penetration depth and signal-to-noise ratio past optical absorbers. The researchers believe creating optical manipulation techniques to maximize photon density could provide a solution. As a result, they have created a motorized photoacoustic holder that allows users to easily maneuver the aim of the device and tune the depth where light is focused, improving the light penetration depth and signal-to-noise ratio.

###

A video about the acoustic tomography is available at https://bit.ly/2yJddb0. A complete list of co-authors is available in the abstract. The research has been funded by the National Institutes of Health.

The Purdue researchers are interested in talking with other companies about other possible uses for photoacoustic tomography. The researchers have a patent pending for the technology with the help of the Purdue Office of Technology Commercialization.

About Purdue Office of Technology Commercialization

The Purdue Office of Technology Commercialization operates one of the most comprehensive technology transfer programs among leading research universities in the U.S. Services provided by this office support the economic development initiatives of Purdue University and benefit the university's academic activities.The office is managed by the Purdue Research Foundation, which received the 2016 Innovation and Economic Prosperity Universities Award for Innovation from the Association of Public and Land-grant Universities. For more information about funding and investment opportunities in startups based on a Purdue innovation, contact the Purdue Foundry at foundry@prf.org. For more information on licensing a Purdue innovation, contact the Office of Technology Commercialization at innovation@prf.org.

Purdue Research Foundation contact: Tom Coyne, 765-588-1044, tjcoyne@prf.org

Source: Craig Goergen, cgoergen@purdue.edu

Media Contact

Tom Coyne
tjcoyne@prf.org
765-588-1044

 @PurdueUnivNews

http://www.purdue.edu/ 

Tom Coyne | EurekAlert!
Further information:
https://www.purdue.edu/newsroom/releases/2018/Q3/purdue-researchers-developing-novel-biomedical-imaging-system-combining-optical,-ultrasound-technology.html
http://dx.doi.org/10.1016/j.pacs.2018.08.002

More articles from Health and Medicine:

nachricht Study shows novel protein plays role in bacterial vaginosis
13.12.2019 | University of Arizona Health Sciences

nachricht Illinois team develops first of a kind in-vitro 3D neural tissue model
12.12.2019 | University of Illinois College of Engineering

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Virus multiplication in 3D

Vaccinia viruses serve as a vaccine against human smallpox and as the basis of new cancer therapies. Two studies now provide fascinating insights into their unusual propagation strategy at the atomic level.

For viruses to multiply, they usually need the support of the cells they infect. In many cases, only in their host’s nucleus can they find the machines,...

Im Focus: Cheers! Maxwell's electromagnetism extended to smaller scales

More than one hundred and fifty years have passed since the publication of James Clerk Maxwell's "A Dynamical Theory of the Electromagnetic Field" (1865). What would our lives be without this publication?

It is difficult to imagine, as this treatise revolutionized our fundamental understanding of electric fields, magnetic fields, and light. The twenty original...

Im Focus: Highly charged ion paves the way towards new physics

In a joint experimental and theoretical work performed at the Heidelberg Max Planck Institute for Nuclear Physics, an international team of physicists detected for the first time an orbital crossing in the highly charged ion Pr⁹⁺. Optical spectra were recorded employing an electron beam ion trap and analysed with the aid of atomic structure calculations. A proposed nHz-wide transition has been identified and its energy was determined with high precision. Theory predicts a very high sensitivity to new physics and extremely low susceptibility to external perturbations for this “clock line” making it a unique candidate for proposed precision studies.

Laser spectroscopy of neutral atoms and singly charged ions has reached astonishing precision by merit of a chain of technological advances during the past...

Im Focus: Ultrafast stimulated emission microscopy of single nanocrystals in Science

The ability to investigate the dynamics of single particle at the nano-scale and femtosecond level remained an unfathomed dream for years. It was not until the dawn of the 21st century that nanotechnology and femtoscience gradually merged together and the first ultrafast microscopy of individual quantum dots (QDs) and molecules was accomplished.

Ultrafast microscopy studies entirely rely on detecting nanoparticles or single molecules with luminescence techniques, which require efficient emitters to...

Im Focus: How to induce magnetism in graphene

Graphene, a two-dimensional structure made of carbon, is a material with excellent mechanical, electronic and optical properties. However, it did not seem suitable for magnetic applications. Together with international partners, Empa researchers have now succeeded in synthesizing a unique nanographene predicted in the 1970s, which conclusively demonstrates that carbon in very specific forms has magnetic properties that could permit future spintronic applications. The results have just been published in the renowned journal Nature Nanotechnology.

Depending on the shape and orientation of their edges, graphene nanostructures (also known as nanographenes) can have very different properties – for example,...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

The Future of Work

03.12.2019 | Event News

First International Conference on Agrophotovoltaics in August 2020

15.11.2019 | Event News

Laser Symposium on Electromobility in Aachen: trends for the mobility revolution

15.11.2019 | Event News

 
Latest News

Supporting structures of wind turbines contribute to wind farm blockage effect

13.12.2019 | Physics and Astronomy

Chinese team makes nanoscopy breakthrough

13.12.2019 | Physics and Astronomy

Tiny quantum sensors watch materials transform under pressure

13.12.2019 | Materials Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>