Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Prove of the maternal influence for the development of Alzheimer’s disease

26.04.2012
Neurodegenerative disorders with dementia play an increasing role in the aging western population, esp. for the care and health systems. In 2050, an estimated number of 106-360 million demented patients have to be taken care of.

Alzheimer’s disease comprises 2/3 of all dementia cases. It is an age-related disease that starts to effect patients in their 60ies and older. Only less than 1% are hereditary cases where specific mutations are known.

Till now, age is the most important risk factor for sporadic Alzheimer’s disease with the risk being even more elevated if the mother or the grandmother were sufferers.

The research team led by Jens Pahnke (M.D., Ph.D., E.F.N.) from the University of Magdeburg (Germany) discovered an important link between maternal inheritance and the deposition of toxic amyloid in Alzheimer’s disease. They established new mouse models that mimic the maternal inheritance of mitochondria. In an international collaboration with colleagues from the USA, Canada, France and Germany they discovered that increased activity of mitochondria leads to a reduced deposition rate of the toxic Alzheimer peptides.
In mice with the highest mitochondrial activity they discovered an approximately 80% reduction of amyloid as compared to mice with mitochondria that exhibited much lower activity. In October 2011, they discovered a new Alzheimer’s gene that also directly depends on the cellular energy produced by the mitochondria. Now they link these new findings to explain age related changes, maternal inheritance and impairment of toxic amyloid export from the brain.

Interestingly, the mental capacity of the brain is directly linked to the availability of energy as produced by mitochondria. It has long been discussed why high education and rate of disease are inversely correlated. The different activities of mitochondria may provide a tool to explain the latter fact.

Artikel/article online 0:23, 21.Apr.2012 in Acta Neuropathologica
http://www.springerlink.com/openurl.asp?genre=article&id=doi:10.1007/
s00401-012-0980-x

Contact information:
Jens Pahnke, Universität Magdeburg, Neurodegeneration Research Lab (NRL), Leipziger Str 44, 39120 Magdeburg, Germany, Tel: +49 391 67 24514, Email: jens.pahnke@gmail.com

Kornelia Suske | idw
Further information:
http://www.NRL.ovgu.de

More articles from Health and Medicine:

nachricht Potential seen for tailoring treatment for acute myeloid leukemia
10.12.2018 | University of Washington Health Sciences/UW Medicine

nachricht UC San Diego researchers develop sensors to detect and measure cancer's ability to spread
06.12.2018 | University of California - San Diego

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Researchers develop method to transfer entire 2D circuits to any smooth surface

What if a sensor sensing a thing could be part of the thing itself? Rice University engineers believe they have a two-dimensional solution to do just that.

Rice engineers led by materials scientists Pulickel Ajayan and Jun Lou have developed a method to make atom-flat sensors that seamlessly integrate with devices...

Im Focus: Three components on one chip

Scientists at the University of Stuttgart and the Karlsruhe Institute of Technology (KIT) succeed in important further development on the way to quantum Computers.

Quantum computers one day should be able to solve certain computing problems much faster than a classical computer. One of the most promising approaches is...

Im Focus: Substitute for rare earth metal oxides

New Project SNAPSTER: Novel luminescent materials by encapsulating phosphorescent metal clusters with organic liquid crystals

Nowadays energy conversion in lighting and optoelectronic devices requires the use of rare earth oxides.

Im Focus: A bit of a stretch... material that thickens as it's pulled

Scientists have discovered the first synthetic material that becomes thicker - at the molecular level - as it is stretched.

Researchers led by Dr Devesh Mistry from the University of Leeds discovered a new non-porous material that has unique and inherent "auxetic" stretching...

Im Focus: The force of the vacuum

Scientists from the Theory Department of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science (CFEL) in Hamburg have shown through theoretical calculations and computer simulations that the force between electrons and lattice distortions in an atomically thin two-dimensional superconductor can be controlled with virtual photons. This could aid the development of new superconductors for energy-saving devices and many other technical applications.

The vacuum is not empty. It may sound like magic to laypeople but it has occupied physicists since the birth of quantum mechanics.

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

New Plastics Economy Investor Forum - Meeting Point for Innovations

10.12.2018 | Event News

EGU 2019 meeting: Media registration now open

06.12.2018 | Event News

Expert Panel on the Future of HPC in Engineering

03.12.2018 | Event News

 
Latest News

Small but ver­sat­ile; key play­ers in the mar­ine ni­tro­gen cycle can util­ize cy­anate and urea

10.12.2018 | Life Sciences

New method gives microscope a boost in resolution

10.12.2018 | Physics and Astronomy

Carnegie Mellon researchers probe hydrogen bonds using new technique

10.12.2018 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>