In her thesis, neuroscience researcher Daniella Rylander presents two important findings that tackle different stages in the development of the uncontrollable jerky movements known as dyskinesia, which are an undesirable effect of treatment with the standard drug levodopa.
Dr Rylander has studied two different systems in the brain that are believed to play an important role in the development of the side effects – glutamate and serotonin. An overactivation of glutamate signals, caused by treatment with levodopa, probably contributes to the development of dyskinesia. Daniella Rylander’s research focuses on blocking this undesirable overactivation.
“The receptor cells have different receptors on their surface where the glutamate is taken in to activate the cell. It is these receptors that I have tried to block. If we could find the right channel and subdue it then we could get more effective treatment with levodopa without any side effects. This has always been my goal”, says Daniella Rylander.
Tests in animal models, including rats, have shown very good results for the new method. A drug that blocks glutamate overactivation via the glutamate receptor ‘mGluR5’ was used in the study. This has previously been tested on humans and so provides a head start in the time-consuming clinical trials required before a new drug can be introduced.
Serotonin also plays an important role in the development of dyskinesia in Parkinson’s disease.
“We have now shown for the first time that individuals who have a particularly large amount of a certain type of fibre on their serotonin cells are also at greater risk of being affected by dyskinesia after levodopa treatment”, says Daniella Rylander.
The new finding of a clear pathological change in the serotonin system can now be utilised to better tailor the individual treatment of patients with Parkinson’s disease.
Daniella Rylander, who is part of the Basal Ganglia Pathophysiology Unit research group, defended her PhD thesis on 17 September 2010. The thesis is entitled Involvement of non-dopaminergic systems in L-DOPA-induced dyskinesia.
To contact Daniella Rylander: tel. +46 (0)46 222 36 19, Daniella.Rylander@med.lu.se
Pressofficer Megan Grindlay; +46-46 222 7308; email@example.com
Megan Grindlay | idw
Study tracks inner workings of the brain with new biosensor
16.08.2018 | Rheinische Friedrich-Wilhelms-Universität Bonn
Foods of the future
15.08.2018 | Georg-August-Universität Göttingen
There are currently great hopes for solid-state batteries. They contain no liquid parts that could leak or catch fire. For this reason, they do not require cooling and are considered to be much safer, more reliable, and longer lasting than traditional lithium-ion batteries. Jülich scientists have now introduced a new concept that allows currents up to ten times greater during charging and discharging than previously described in the literature. The improvement was achieved by a “clever” choice of materials with a focus on consistently good compatibility. All components were made from phosphate compounds, which are well matched both chemically and mechanically.
The low current is considered one of the biggest hurdles in the development of solid-state batteries. It is the reason why the batteries take a relatively long...
New design tool automatically creates nanostructure 3D-print templates for user-given colors
Scientists present work at prestigious SIGGRAPH conference
Most of the objects we see are colored by pigments, but using pigments has disadvantages: such colors can fade, industrial pigments are often toxic, and...
Scientists at the University of California, Los Angeles present new research on a curious cosmic phenomenon known as "whistlers" -- very low frequency packets...
Scientists develop first tool to use machine learning methods to compute flow around interactively designable 3D objects. Tool will be presented at this year’s prestigious SIGGRAPH conference.
When engineers or designers want to test the aerodynamic properties of the newly designed shape of a car, airplane, or other object, they would normally model...
Researchers from TU Graz and their industry partners have unveiled a world first: the prototype of a robot-controlled, high-speed combined charging system (CCS) for electric vehicles that enables series charging of cars in various parking positions.
Global demand for electric vehicles is forecast to rise sharply: by 2025, the number of new vehicle registrations is expected to reach 25 million per year....
17.08.2018 | Event News
08.08.2018 | Event News
27.07.2018 | Event News
21.08.2018 | Ecology, The Environment and Conservation
21.08.2018 | Life Sciences
21.08.2018 | Power and Electrical Engineering