Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

PolyU study sheds new light on anti-inflammatory mechanism of unique marine oil

26.01.2009
A pioneering research by The Hong Kong Polytechnic University (PolyU) has uncovered the previously unknown anti-inflammatory mechanism for soothing the pain arising from arthritis, and thus unlocked the key to conducting further researches on the relationship between functional foods and this common crippling disease.

This research was undertaken by a team led by Professor Samuel Lo Chun-lap of the Department of Applied Biology and Chemical Technology in the University’s Proteomics Laboratory. The team was intrigued by whether consumption of a food supplement would alleviate the symptom of arthritis, and they started with testing the oil of Perna canaliculus, the green-lipped mussel of New Zealand, on rats with adjuvant-induced arthritis.

In a series of studies conducted by Professor Lo and his team, the oil extract was shown to be able to relieve pain in the animals; modulate cytokines with a decrease in cytokines associated with inflammation, and lead to an increase in IL-10 (a cytokine that controls inflammation).

More importantly, the oil extract decreased the synthesis of some proteins associated with inflammation, while increasing the synthesis of the anti-inflammatory enzyme MDH. Decreased expression of proteins related to inflammation was uncovered by proteomic technologies. This discovery has therefore cast new light on the anti-inflammatory function of this oil and the underlying mechanism of soothing arthritis.

The result of this ground-breaking study was published under the title of “Differential protein expression induced by a lipid extract of Perna canaliculus in splenocytes of rats with adjuvant-induced arthritis” in the Inflammopharmacology journal in 2008.

Encouraged by the findings, PolyU researchers are planning to test the anti-inflammatory functions of other common foods as well as Chinese herbs. They will also involve athletes and sportsmen besieged by arthritis in the next stage of research. Prof. Lo will be working alongside with Associate Professor Dr Mason Leung of the University’s Department of Rehabilitation Sciences in the next stage.

The oil of Perna canaliculus, the green-lipped mussel of New Zealand, when extracted by super-critical extraction is free of protein and carbohydrate. A large number of studies have been published on its composition, complex mode of action, activity in animal models, and efficacy in controlling osteoarthritis and moderate asthma in patients.

These studies were supported in part by an unrestricted grant for education and research from Pharmalink International Ltd.

Press Contact: Professor Samuel Lo
Department of Applied Biology and Chemical Technology
Telephone: (852) 3400 8669
E-mail: bcsamlo@polyu.edu.hk

Yu Kit Sun Regina | ResearchSEA
Further information:
http://www.polyu.edu.hk
http://www.researchsea.com

More articles from Health and Medicine:

nachricht The genes are not to blame
20.07.2018 | Technische Universität München

nachricht Targeting headaches and tumors with nano-submarines
20.07.2018 | Universitätsmedizin der Johannes Gutenberg-Universität Mainz

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Future electronic components to be printed like newspapers

A new manufacturing technique uses a process similar to newspaper printing to form smoother and more flexible metals for making ultrafast electronic devices.

The low-cost process, developed by Purdue University researchers, combines tools already used in industry for manufacturing metals on a large scale, but uses...

Im Focus: First evidence on the source of extragalactic particles

For the first time ever, scientists have determined the cosmic origin of highest-energy neutrinos. A research group led by IceCube scientist Elisa Resconi, spokesperson of the Collaborative Research Center SFB1258 at the Technical University of Munich (TUM), provides an important piece of evidence that the particles detected by the IceCube neutrino telescope at the South Pole originate from a galaxy four billion light-years away from Earth.

To rule out other origins with certainty, the team led by neutrino physicist Elisa Resconi from the Technical University of Munich and multi-wavelength...

Im Focus: Magnetic vortices: Two independent magnetic skyrmion phases discovered in a single material

For the first time a team of researchers have discovered two different phases of magnetic skyrmions in a single material. Physicists of the Technical Universities of Munich and Dresden and the University of Cologne can now better study and understand the properties of these magnetic structures, which are important for both basic research and applications.

Whirlpools are an everyday experience in a bath tub: When the water is drained a circular vortex is formed. Typically, such whirls are rather stable. Similar...

Im Focus: Breaking the bond: To take part or not?

Physicists working with Roland Wester at the University of Innsbruck have investigated if and how chemical reactions can be influenced by targeted vibrational excitation of the reactants. They were able to demonstrate that excitation with a laser beam does not affect the efficiency of a chemical exchange reaction and that the excited molecular group acts only as a spectator in the reaction.

A frequently used reaction in organic chemistry is nucleophilic substitution. It plays, for example, an important role in in the synthesis of new chemical...

Im Focus: New 2D Spectroscopy Methods

Optical spectroscopy allows investigating the energy structure and dynamic properties of complex quantum systems. Researchers from the University of Würzburg present two new approaches of coherent two-dimensional spectroscopy.

"Put an excitation into the system and observe how it evolves." According to physicist Professor Tobias Brixner, this is the credo of optical spectroscopy....

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Leading experts in Diabetes, Metabolism and Biomedical Engineering discuss Precision Medicine

13.07.2018 | Event News

Conference on Laser Polishing – LaP: Fine Tuning for Surfaces

12.07.2018 | Event News

11th European Wood-based Panel Symposium 2018: Meeting point for the wood-based materials industry

03.07.2018 | Event News

 
Latest News

A smart safe rechargeable zinc ion battery based on sol-gel transition electrolytes

20.07.2018 | Power and Electrical Engineering

Reversing cause and effect is no trouble for quantum computers

20.07.2018 | Information Technology

Princeton-UPenn research team finds physics treasure hidden in a wallpaper pattern

20.07.2018 | Materials Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>