For the third of all epilepsy patients who don't respond to medication, an alternative is to locate the small cluster of neurons that act as the seed of a seizure's aberrant electrical activity and surgically remove it. Unfortunately, such surgeries often fail to bring any relief. The ability to reliably pinpoint the anatomical source of seizures, different for each patient, remains elusive.
Researchers at the University of Pennsylvania's School of Engineering and Applied Science and Perelman School of Medicine are looking for ways to refine this process by looking at networks of electrical activity in the brain just prior to the onset of a seizure.
'These new computational techniques allow us to see how different parts of the brain are communicating with one another as we go about our daily lives,' Bassett said. 'Critically, we can see how these communication patterns change as the brain changes its activity. This new ability offers a fundamental understanding of the functional relationships that drive a seizure.'
Credit: University of Pennsylvania
Using brain data crowdsourced from 22 epilepsy patients with implanted electrodes, the researchers have developed a series of algorithms that can predict where in the brain a seizure will originate and which groups of neurons it will likely spread to as it grows.
Such algorithms could provide a more objective way of identifying surgical targets, improving the success rate of such interventions.
And because the data also provide for a generalizable model of how seizures evolve and spread through neural networks, they could also inform less invasive forms of treatments. An implantable device, for example, could monitor these warning signs and automatically deliver precise electrical impulses that would neutralize the seizure before it manifests.
The research was led by Danielle Bassett, the Skirkanich Assistant Professor of Innovation in Penn Engineering; Brian Litt, a professor of Neurology in Penn's Perelman School of Medicine and of Bioengineering in Penn Engineering; and Ankit Khambhati, a graduate student in the Litt Lab.
It was published in the journal PLOS Computational Biology.
"By mapping the network of activity in the brain and how it changes over time," Bassett said, "we aim to quantify the reconfiguration of this network that leads to different stages of a seizure."
"Using the novel algorithms we've generated to parse seizures into different states," Khambhati said, "we can answer questions such as, 'In which state is the seizure beginning?,' and 'In which state does it begin to spread?'"
At the core of the research team's findings is the International Epilepsy Electrophysiology Portal, founded by Litt; Zachary Ives, a professor and Markowitz Faculty Fellow in Penn Engineering's Department of Computer & Information Science; and Gregory Worrell, a neurologist at the Mayo Clinic. It was designed to collect direct brain recordings from epilepsy patients the world over.
Each patient in the study has between 80 and 100 electrodes implanted in regions of the brain that preliminary tests suggested were the sources of seizures. The electrodes indirectly record the voltage of brain activity in the neurons they sit above.
In this study, the researchers used recordings of 88 seizures from 22 patients.
"Localizing epileptic networks is one of the biggest challenges we have in treating medication-resistant epilepsy," said Litt, who is also director of the Penn Epilepsy Center. "Bringing Dr. Bassett and her team to work with us on this task has tremendous potential to help our patients."
Bassett's research interests involve applying insights from network science to the brain. In earlier work, she and colleagues developed a way of illustrating the functional connectivity between large groups of neurons by comparing the similarity of their activity over time. The similarity between the activation patterns of two large groups of neurons suggests the degree to which they are in communication.
"These new computational techniques allow us to see how different parts of the brain are communicating with one another as we go about our daily lives," Bassett said. "Critically, we can see how these communication patterns change as the brain changes its activity. This new ability offers a fundamental understanding of the functional relationships that drive a seizure."
Because the geographical progression of each patient's seizure is different, the researchers aimed to find some commonality in the network structure of the neuronal groups involved. While the location of the seizure's source might change from person to person, the way the aberrant electrical activity spreads from there may have generalizable patterns. Researchers could then work backwards from those patterns to better identify the source, or devise ways of interrupting that progression to stop a seizure in its tracks.
The researchers showed they could predict where a seizure would begin based on network structure alone.
"We show there is a high correspondence between certain topological features that are predictive of brain regions that initiate seizures," Khambhati said. "Specifically, we can use pre-seizure brain activity to determine the regions that are mostly densely interconnected, as they're most likely to be where the seizure starts."
Similar insights also showed the regions to which aberrant activity was likely to spread.
"Prior to and during the seizure," Khambhati said, "the region of the brain where the seizure originates remains densely interconnected, but what we are finding is that, as the seizure is beginning, the less densely connected regions are reconfiguring very rapidly. We believe that rapid reconfiguration is the signal that a seizure is about to manifest. "
The researchers believe algorithms based on these network relationships could immediately aid in pinpointing surgical targets in patients' brains and eventually inform implantable devices that can neutralize seizures before they spread.
Data hosted on the International Epilepsy Electrophysiology Portal is freely available to the public. Information on how to access or contribute data is available at IEEG.org.
Also contributing to the study were, from the Perelman School of Medicine, Kathryn Davis, an assistant professor of neurology; Stephanie Chen, an instructor of neurology; Timothy Lucas, an assistant professor of neurosurgery; and Brian Oommen, a resident/fellow.
The study was supported by the National Institutes of Health through awards R01- NS063039 and 1U24 NS 63930-01A1, Citizens United for Research in Epilepsy, the Mirowski Foundation, the John D. and Catherine T. MacArthur Foundation, the Alfred P. Sloan Foundation, the Army Research Laboratory and the Army Research Office through contract numbers W911NF-10-2-0022 and W911NF-14-1- 0679, the National Institute of Mental Health through award 2-R01-DC-009209-11, the National Institute of Child Health and Human Development through award 1-R01-HD086888-01, the Office of Naval Research and the National Science Foundation through awards BCS-1441502 and BCS-1430087.
Evan Lerner | EurekAlert!
Collagen nanofibrils in mammalian tissues get stronger with exercise
14.12.2018 | University of Illinois College of Engineering
New discoveries predict ability to forecast dementia from single molecule
12.12.2018 | UT Southwestern Medical Center
Researchers from the University of Basel have reported a new method that allows the physical state of just a few atoms or molecules within a network to be controlled. It is based on the spontaneous self-organization of molecules into extensive networks with pores about one nanometer in size. In the journal ‘small’, the physicists reported on their investigations, which could be of particular importance for the development of new storage devices.
Around the world, researchers are attempting to shrink data storage devices to achieve as large a storage capacity in as small a space as possible. In almost...
The more objects we make "smart," from watches to entire buildings, the greater the need for these devices to store and retrieve massive amounts of data quickly without consuming too much power.
Millions of new memory cells could be part of a computer chip and provide that speed and energy savings, thanks to the discovery of a previously unobserved...
What if, instead of turning up the thermostat, you could warm up with high-tech, flexible patches sewn into your clothes - while significantly reducing your...
A widely used diabetes medication combined with an antihypertensive drug specifically inhibits tumor growth – this was discovered by researchers from the University of Basel’s Biozentrum two years ago. In a follow-up study, recently published in “Cell Reports”, the scientists report that this drug cocktail induces cancer cell death by switching off their energy supply.
The widely used anti-diabetes drug metformin not only reduces blood sugar but also has an anti-cancer effect. However, the metformin dose commonly used in the...
A research team from the University of Zurich has developed a new drone that can retract its propeller arms in flight and make itself small to fit through narrow gaps and holes. This is particularly useful when searching for victims of natural disasters.
Inspecting a damaged building after an earthquake or during a fire is exactly the kind of job that human rescuers would like drones to do for them. A flying...
12.12.2018 | Event News
10.12.2018 | Event News
06.12.2018 | Event News
18.12.2018 | Materials Sciences
18.12.2018 | Physics and Astronomy
18.12.2018 | Physics and Astronomy