Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Pegylated liposomal doxorubicin beneficial in metastatic breast cancer

16.09.2008
For women with metastatic breast cancer, treatment with an encapsulated form of the drug doxorubicin offers a well-tolerated option for maintenance therapy that delays progression and offers benefits in terms of survival, new results show.

Spanish researchers led by Dr. Emilio Alba have been studying the effects of pegylated liposomal doxorubicin in a group of 155 women who had already been treated with chemotherapy.

At the 33rd Congress of the European Society for Medical Oncology (ESMO) in Stockholm, they present long-term follow-up data showing that 81% of patients prescribed the drug were alive after one year, compared to 66% of those who did not receive the treatment.

The aim of the therapy was to delay progression of disease while inflicting as few side-effects as possible, said Dr. Alba.

“Despite major advances in adjuvant therapy, the number of patients with metastatic breast cancer who are expected to relapse is substantial,” he said. “In this setting the treatment is not curative, but it is important to explore all the available alternatives.”

“In the case of chemotherapy, toxicity is the main drawback. Almost all studies carried out up to now associate maintenance therapy with a longer time-to-progression, and sometimes more overall survival. However, dealing with toxicity forces us to balance benefits and risks.”

“The main finding of this trial was the low toxicity profile of pegylated liposomal doxorubicin at a dose of 40mg/m2. This dose presented no gastrointestinal toxicity, no grade IV alopecia, and grade IV adverse effects such as mucositis or hand-and-foot syndrome (HFS) were lower than 5%. The treatment also presented no cardiotoxicity. The subjective tolerance was very good.”

Women treated with the drug saw a mean increase in time-to-progression of 3.4 months, the researchers found, which is similar to that of new targeted drugs such as trastuzumab or lapanitib. “While a month would probably fall short, a recent survey indicated 51% of oncologists would consider a time-to-progression increase of 3 months as successful,” Dr. Alba said.

“Maintenance therapy is a good option for almost everybody, if we can design effective treatments associated with a good toxicity profile. I think this goal is achieved in the case of pegylated liposomal doxorubicin,” he said.

Vanessa Pavinato | alfa
Further information:
http://www.esmo.org

More articles from Health and Medicine:

nachricht When wheels and heads are spinning - DFG research project on motion sickness in automated driving
22.05.2019 | Technische Universität Berlin

nachricht A new approach to targeting cancer cells
20.05.2019 | University of California - Riverside

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Self-repairing batteries

UTokyo engineers develop a way to create high-capacity long-life batteries

Engineers at the University of Tokyo continually pioneer new ways to improve battery technology. Professor Atsuo Yamada and his team recently developed a...

Im Focus: Quantum Cloud Computing with Self-Check

With a quantum coprocessor in the cloud, physicists from Innsbruck, Austria, open the door to the simulation of previously unsolvable problems in chemistry, materials research or high-energy physics. The research groups led by Rainer Blatt and Peter Zoller report in the journal Nature how they simulated particle physics phenomena on 20 quantum bits and how the quantum simulator self-verified the result for the first time.

Many scientists are currently working on investigating how quantum advantage can be exploited on hardware already available today. Three years ago, physicists...

Im Focus: Accelerating quantum technologies with materials processing at the atomic scale

'Quantum technologies' utilise the unique phenomena of quantum superposition and entanglement to encode and process information, with potentially profound benefits to a wide range of information technologies from communications to sensing and computing.

However a major challenge in developing these technologies is that the quantum phenomena are very fragile, and only a handful of physical systems have been...

Im Focus: A step towards probabilistic computing

Working group led by physicist Professor Ulrich Nowak at the University of Konstanz, in collaboration with a team of physicists from Johannes Gutenberg University Mainz, demonstrates how skyrmions can be used for the computer concepts of the future

When it comes to performing a calculation destined to arrive at an exact result, humans are hopelessly inferior to the computer. In other areas, humans are...

Im Focus: Recording embryonic development

Scientists develop a molecular recording tool that enables in vivo lineage tracing of embryonic cells

The beginning of new life starts with a fascinating process: A single cell gives rise to progenitor cells that eventually differentiate into the three germ...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

SEMANTiCS 2019 brings together industry leaders and data scientists in Karlsruhe

29.04.2019 | Event News

Revered mathematicians and computer scientists converge with 200 young researchers in Heidelberg!

17.04.2019 | Event News

First dust conference in the Central Asian part of the earth’s dust belt

15.04.2019 | Event News

 
Latest News

Summit charts a course to uncover the origins of genetic diseases

22.05.2019 | Life Sciences

New study finds distinct microbes living next to corals

22.05.2019 | Life Sciences

Stellar waltz with dramatic ending

22.05.2019 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>