The study suggests a need for re-interpretation of earlier findings that suggested NSAIDs can prevent the disease. The research is published in the April 22, 2009, online issue of Neurology®, the medical journal of the American Academy of Neurology.
Researchers identified 2,736 members of Group Health, an integrated healthcare delivery system, who did not have dementia when they enrolled in the study at an average age of 75. The investigators followed these people for 12 years to see if they developed Alzheimer’s or dementia. They checked Group Health pharmacy records for NSAID prescriptions and also asked participants about their use of NSAIDs.
Of the participants, 351 people had a history of heavy use of NSAIDs at the start of the study, and another 107 people became heavy NSAID users during the follow-up period. Heavy use was defined as having prescriptions for NSAIDs 68 percent of the time or more over a two-year period.
During the study, 476 people developed Alzheimer’s disease or dementia. The risk of developing dementia among heavy NSAID users was 66 percent higher than among people with little or no NSAID use.
“A key difference between this study and most of those done earlier is that our participants were older,” said study author John C. S. Breitner, MD, MPH, of the Department of Veterans Affairs and the University of Washington School of Medicine in Seattle. “It has been argued for some time that NSAID use delays the onset of Alzheimer’s disease. It would follow that studies looking at younger people who use NSAIDs would show fewer cases of Alzheimer’s, while in groups of older people there might be more cases, including those that would have occurred earlier if they had not been delayed.”
“This is one interpretation of the results, but other explanations are possible,” cautioned Breitner, who added, “We must not ignore the fundamental finding, which is an increase in the risk of dementia in the NSAID users. We need further research to understand that result more clearly.”
The study was supported by the U.S. Department of Veterans Affairs, the National Institutes of Health, and the Paul B. Beeson Career Development Awards in Aging Research Program.
The American Academy of Neurology, an association of more than 21,000 neurologists and neuroscience professionals, is dedicated to improving patient care through education and research. A neurologist is a doctor with specialized training in diagnosing, treating and managing disorders of the brain and nervous system such as multiple sclerosis, restless legs syndrome, Alzheimer’s disease, narcolepsy, and stroke.
Rachel Seroka | American Academy of Neurology
Enabling technology in cell-based therapies: Scale-up, scale-out or program in-place
23.07.2018 | SLAS (Society for Laboratory Automation and Screening)
FAU researchers identify Parkinson's disease as a possible autoimmune disease
23.07.2018 | Friedrich-Alexander-Universität Erlangen-Nürnberg
A new manufacturing technique uses a process similar to newspaper printing to form smoother and more flexible metals for making ultrafast electronic devices.
The low-cost process, developed by Purdue University researchers, combines tools already used in industry for manufacturing metals on a large scale, but uses...
For the first time ever, scientists have determined the cosmic origin of highest-energy neutrinos. A research group led by IceCube scientist Elisa Resconi, spokesperson of the Collaborative Research Center SFB1258 at the Technical University of Munich (TUM), provides an important piece of evidence that the particles detected by the IceCube neutrino telescope at the South Pole originate from a galaxy four billion light-years away from Earth.
To rule out other origins with certainty, the team led by neutrino physicist Elisa Resconi from the Technical University of Munich and multi-wavelength...
For the first time a team of researchers have discovered two different phases of magnetic skyrmions in a single material. Physicists of the Technical Universities of Munich and Dresden and the University of Cologne can now better study and understand the properties of these magnetic structures, which are important for both basic research and applications.
Whirlpools are an everyday experience in a bath tub: When the water is drained a circular vortex is formed. Typically, such whirls are rather stable. Similar...
Physicists working with Roland Wester at the University of Innsbruck have investigated if and how chemical reactions can be influenced by targeted vibrational excitation of the reactants. They were able to demonstrate that excitation with a laser beam does not affect the efficiency of a chemical exchange reaction and that the excited molecular group acts only as a spectator in the reaction.
A frequently used reaction in organic chemistry is nucleophilic substitution. It plays, for example, an important role in in the synthesis of new chemical...
Optical spectroscopy allows investigating the energy structure and dynamic properties of complex quantum systems. Researchers from the University of Würzburg present two new approaches of coherent two-dimensional spectroscopy.
"Put an excitation into the system and observe how it evolves." According to physicist Professor Tobias Brixner, this is the credo of optical spectroscopy....
13.07.2018 | Event News
12.07.2018 | Event News
03.07.2018 | Event News
23.07.2018 | Science Education
23.07.2018 | Health and Medicine
23.07.2018 | Life Sciences