Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Oxidative Stress Is Significant Predictor for Hip Fracture, Research Shows

13.08.2014

Oxidative stress is a significant predictor for hip fracture in postmenopausal women, according to new research led by University of Cincinnati (UC) epidemiologists.

The research, appearing online ahead of print in the Journal of Bone and Mineral Research, was led by Tianying Wu, MD, PhD, an assistant professor in the UC College of Medicine Department of Environmental Health, and Shuman Yang, a postdoctoral fellow in the department. They collaborated with researchers from the Harvard School of Public Health and Harvard Medical School.


"To our knowledge, this is the first prospective study among postmenopausal women demonstrating that oxidative stress was a significant predictor for hip fracture,” says Wu, the study’s corresponding author. 


Oxidative stress is defined as physiological stress on the body that is caused by the cumulative damage done by free radicals, which are inadequately neutralized by antioxidants. Free radicals are unstable molecules that react with other substances in the human body to damage cells or organs.


Oxidative stress occurs naturally, but environmental factors such as natural and artificial radiation, toxins in air, food and water and miscellaneous sources such as tobacco smoke can add to the overall burden and defeat the body’s antioxidant defenses.


The researchers assessed oxidative stress by measuring fluorescent oxidation products (FlOP) in blood plasma. FlOP reflects a mixture of oxidation products from lipids, proteins and DNA and can be measured by a fluorescent spectrophotometer.


Researchers studied participants in the Nurses’ Health Study, which began in 1976 with funding from the National Institutes of Health (NIH). Participants are female nurses who periodically respond to questionnaires and submit samples.


The researchers studied 996 women aged 60 or older at baseline blood collection (1989-1990). Plasma FlOPs were measured at three excitation/emission wavelengths: 360/420 nm (nanometers), named as FlOP_360; 320/420 nm, named as FlOP_320; and 400-475 nm, named as FlOP_400.


FlOP_360 represents oxidation products that are generated from oxidized phospholipids  or from lipid oxidation products reacting with proteins. FlOP_320 is formed when oxidation products such as lipid hydroperoxides, aldehydes and ketones react with DNA in the presence of metals. FlOP_400 reflects the interaction between malondialdehyde (a specific marker for lipid oxidation), proteins and phospholipids.


Of the three wavelengths, researchers found that baseline levels of FlOP_320 products predicted risk of future hip fracture in the study cohort. (No association was found with FlOP_360 and FlOP_400.) Increased FlOP_320 was associated with greater risk of hip fracture; women in the upper 30 percent of FlOP_320 readings were found to have 2.67 times the risk of hip fractures of those in the bottom 30 percent. 


"Because FlOP_320 is generated in the presence of metals, its strong association with hip fractures may reflect the co-existing effect of reactive oxygen species and heavy metals,” says Wu, who notes that the other FlOP products can be generated without metals.


Hip fracture is associated with substantial cost, as well as higher risk of disability, co-morbidities and mortality than any other fractures. Current fracture risk assessment uses traditional risk factors such as age and presence of osteoporosis, but Wu sees FlOP_320 playing an important role in risk assessment.


"If our findings are confirmed in other studies, adding this marker into the existing fracture assessment model could improve the prediction of hip fracture in postmenopausal women,” she says.


The study was funded by grants from the American Heart Association, the NIH’s National Heart, Lung and Blood Institute and National Cancer Institute and the UC Center for Environmental Genetics, funded by the NIH’s National Institute of Environmental Health Sciences.

Keith Herrell | Eurek Alert!
Further information:
http://healthnews.uc.edu/news/?/24960/

Further reports about: DNA Environmental Health Oxidative Stress blood fracture fractures hip phospholipids proteins radicals

More articles from Health and Medicine:

nachricht Underwater Snail-o-Bot gets kick from light
27.02.2020 | Max-Planck-Institut für Intelligente Systeme

nachricht Existing drugs may offer a first-line treatment for coronavirus outbreak
27.02.2020 | Norwegian University of Science and Technology

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: High-pressure scientists in Bayreuth discover promising material for information technology

Researchers at the University of Bayreuth have discovered an unusual material: When cooled down to two degrees Celsius, its crystal structure and electronic properties change abruptly and significantly. In this new state, the distances between iron atoms can be tailored with the help of light beams. This opens up intriguing possibilities for application in the field of information technology. The scientists have presented their discovery in the journal "Angewandte Chemie - International Edition". The new findings are the result of close cooperation with partnering facilities in Augsburg, Dresden, Hamburg, and Moscow.

The material is an unusual form of iron oxide with the formula Fe₅O₆. The researchers produced it at a pressure of 15 gigapascals in a high-pressure laboratory...

Im Focus: From China to the South Pole: Joining forces to solve the neutrino mass puzzle

Study by Mainz physicists indicates that the next generation of neutrino experiments may well find the answer to one of the most pressing issues in neutrino physics

Among the most exciting challenges in modern physics is the identification of the neutrino mass ordering. Physicists from the Cluster of Excellence PRISMA+ at...

Im Focus: Therapies without drugs

Fraunhofer researchers are investigating the potential of microimplants to stimulate nerve cells and treat chronic conditions like asthma, diabetes, or Parkinson’s disease. Find out what makes this form of treatment so appealing and which challenges the researchers still have to master.

A study by the Robert Koch Institute has found that one in four women will suffer from weak bladders at some point in their lives. Treatments of this condition...

Im Focus: A step towards controlling spin-dependent petahertz electronics by material defects

The operational speed of semiconductors in various electronic and optoelectronic devices is limited to several gigahertz (a billion oscillations per second). This constrains the upper limit of the operational speed of computing. Now researchers from the Max Planck Institute for the Structure and Dynamics of Matter in Hamburg, Germany, and the Indian Institute of Technology in Bombay have explained how these processes can be sped up through the use of light waves and defected solid materials.

Light waves perform several hundred trillion oscillations per second. Hence, it is natural to envision employing light oscillations to drive the electronic...

Im Focus: Freiburg researcher investigate the origins of surface texture

Most natural and artificial surfaces are rough: metals and even glasses that appear smooth to the naked eye can look like jagged mountain ranges under the microscope. There is currently no uniform theory about the origin of this roughness despite it being observed on all scales, from the atomic to the tectonic. Scientists suspect that the rough surface is formed by irreversible plastic deformation that occurs in many processes of mechanical machining of components such as milling.

Prof. Dr. Lars Pastewka from the Simulation group at the Department of Microsystems Engineering at the University of Freiburg and his team have simulated such...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

70th Lindau Nobel Laureate Meeting: Around 70 Laureates set to meet with young scientists from approx. 100 countries

12.02.2020 | Event News

11th Advanced Battery Power Conference, March 24-25, 2020 in Münster/Germany

16.01.2020 | Event News

Laser Colloquium Hydrogen LKH2: fast and reliable fuel cell manufacturing

15.01.2020 | Event News

 
Latest News

New molten metal hybrid filters from TU Freiberg will make components even safer and more resistant in the future

28.02.2020 | Materials Sciences

Polymers get caught up in love-hate chemistry of oil and water

28.02.2020 | Life Sciences

Two NE tree species can be used in new sustainable building material

28.02.2020 | Architecture and Construction

VideoLinks
Science & Research
Overview of more VideoLinks >>>