Oestrogen treatment with no side-effects in sight

The study is presented in the respected journal PNAS (Proceedings of the National Academy of Sciences).

Many women are affected by osteoporosis after the menopause, when the body’s production of oestrogen decreases. Oestrogen is the hormone that principally strengthens the bone mass in women, and it is also of significance for the skeleton in men. Treatment of osteoporosis with oestrogens is, however, associated with serious side-effects such as breast cancer and blood clots. In order to develop an oestrogen treatment that utilises the favourable effects of the oestrogen but not its side-effects, the researchers have analysed which parts of the oestrogen receptor is most important in enabling oestrogen to act on bone tissue and other tissues.

Oestrogen has recipient molecules known as oestrogen receptors, which cause the body to respond to oestrogen.

”This is the first study to analyse the significance of different parts of a particular type of oestrogen receptor through studies in mice. It enables us to differentiate the favourable effects of oestrogen in bone tissue from the adverse effects in other tissues,” says Anna Börjesson, a PhD student at the Centre for Bone and Arthritis Research at the Sahlgrenska Academy.

This knowledge improves the prospects of being able to develop new, safer oestrogen treatments in the future.

”The development of special oestrogens that are tailored to bone and only affect a particular part of this type of oestrogen receptor may lead to a more targeted and effective treatment for osteoporosis with minimal side-effects,” Professor Claes Ohlsson explains.

FACTS ABOUT OSTEOPOROSIS
Sweden and Norway have the highest incidence of fractures due to osteoporosis in the world. Sweden and other industrialised countries face a significant increase in the number of osteoporosis fractures as the elderly population increases. Osteoporosis is the cause of 70 000 fractures in Sweden and costs the health service just under SEK 5 billion every year. These fractures often result in impaired mobility and great suffering for patients affected.
For further information, please contact:
Anna Börjesson, researcher at the Centre for Bone and Arthritis Research, Sahlgrenska Academy, +46 (0)31-3423183, mobile +46 (0)702-576918, e-mail: Anna.Borjesson@gu.se

Claes Ohlsson, Professor at the Centre for Bone and Arthritis Research, Sahlgrenska Academy, +46 (0)31-3422873, mobile +46 (0)706-832966, e-mail Claes.Ohlsson@medic.gu.se

Bibliographic data:
Journal: Proceedings of the National Academy of Sciences (PNAS)
Title of the article: Roles of transactivating functions 1 and 2 of estrogen receptor-α in bone

Authors: Börjesson AE, Windahl SH, Lagerquist MK, Engdahl C, Frenkel B, Movérare-Skrtic S, Sjögren K, Kindblom JM, Stubelius A, Islander U, Antal MC, Krust A, Chambon P, Ohlsson C