Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Obesity, alcohol consumption and smoking increase the risk of second breast cancer

09.09.2009
It is well known that survivors of breast cancer have a much higher risk of developing a second breast cancer than women in the general population have of developing a first breast cancer. However, little is known about what lifestyle factors may make survivors more vulnerable to a second cancer.

A new study by researchers at Fred Hutchinson Cancer Research Center, published online Sept. 8 in the Journal of Clinical Oncology, has found that obesity, alcohol use and smoking all significantly increase the risk of second breast cancer among breast cancer survivors.

"We found that obese women had a 50 percent increased risk, women who consumed at least one alcoholic drink per day had a 90 percent increased risk, and women who were current smokers had a 120 percent increased risk of developing a second breast cancer," said lead author Christopher I. Li, M.D., Ph.D., an associate member of the Public Health Sciences Division at the Hutchinson Center. Li, an epidemiologist, primarily studies what causes breast cancer and how it can be prevented.

His study adds to a small but growing body of evidence that obesity (a body mass index of 30 kg/m2 or more), alcohol consumption (consuming at least seven drinks a week) and current smoking may be important risk factors for second breast tumors. The research also suggests that current smokers who imbibe at least seven drinks a week may be at particularly high risk of second breast cancer.

"Our study results afford breast cancer survivors three ways to potentially reduce their risk of second cancers: Stay at a normal weight, don't smoke and drink in moderation," he said.

Both obesity and alcohol use are associated with increased levels of circulating estrogen, and this is thought to be the primary means through which they confer an increased risk of breast cancer, since estrogen can fuel breast cancer growth. The link between smoking and breast cancer may be attributed to carcinogens in tobacco smoke.

For the study, Li and colleagues assessed body mass index, alcohol use and smoking status in 365 women who were diagnosed with both a first and a second breast cancer, and compared them to 726 matched controls diagnosed with only a first breast cancer. Obesity, alcohol use and smoking data were collected from medical record reviews and participant interviews. The study participants, all from the Seattle/Puget Sound region, were first diagnosed with breast cancer between the ages of 40 and 79.

"Breast cancer now has a greater than 90 percent five-year survival rate in the United States, resulting in a large and ever-growing number of survivors. Since these women are at two to six times greater risk of developing a second cancer compared to women in the general population, it is important to understand factors that may increase that risk," Li said. "We know that lifestyle factors such as obesity, smoking and heavy alcohol consumption are linked with a number of life-threatening diseases in addition to cancer, and so reducing or eliminating these factors could have the added benefit of reducing a survivor's risk of developing a second breast cancer."

The National Cancer Institute funded the research.

At Fred Hutchinson Cancer Research Center, our interdisciplinary teams of world-renowned scientists and humanitarians work together to prevent, diagnose and treat cancer, HIV/AIDS and other diseases. Our researchers, including three Nobel laureates, bring a relentless pursuit and passion for health, knowledge and hope to their work and to the world. For more information, please visit fhcrc.org.

Kristen Lidke Woodward | EurekAlert!
Further information:
http://www.fhcrc.org

More articles from Health and Medicine:

nachricht Study tracks inner workings of the brain with new biosensor
16.08.2018 | Rheinische Friedrich-Wilhelms-Universität Bonn

nachricht Foods of the future
15.08.2018 | Georg-August-Universität Göttingen

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Color effects from transparent 3D-printed nanostructures

New design tool automatically creates nanostructure 3D-print templates for user-given colors
Scientists present work at prestigious SIGGRAPH conference

Most of the objects we see are colored by pigments, but using pigments has disadvantages: such colors can fade, industrial pigments are often toxic, and...

Im Focus: Unraveling the nature of 'whistlers' from space in the lab

A new study sheds light on how ultralow frequency radio waves and plasmas interact

Scientists at the University of California, Los Angeles present new research on a curious cosmic phenomenon known as "whistlers" -- very low frequency packets...

Im Focus: New interactive machine learning tool makes car designs more aerodynamic

Scientists develop first tool to use machine learning methods to compute flow around interactively designable 3D objects. Tool will be presented at this year’s prestigious SIGGRAPH conference.

When engineers or designers want to test the aerodynamic properties of the newly designed shape of a car, airplane, or other object, they would normally model...

Im Focus: Robots as 'pump attendants': TU Graz develops robot-controlled rapid charging system for e-vehicles

Researchers from TU Graz and their industry partners have unveiled a world first: the prototype of a robot-controlled, high-speed combined charging system (CCS) for electric vehicles that enables series charging of cars in various parking positions.

Global demand for electric vehicles is forecast to rise sharply: by 2025, the number of new vehicle registrations is expected to reach 25 million per year....

Im Focus: The “TRiC” to folding actin

Proteins must be folded correctly to fulfill their molecular functions in cells. Molecular assistants called chaperones help proteins exploit their inbuilt folding potential and reach the correct three-dimensional structure. Researchers at the Max Planck Institute of Biochemistry (MPIB) have demonstrated that actin, the most abundant protein in higher developed cells, does not have the inbuilt potential to fold and instead requires special assistance to fold into its active state. The chaperone TRiC uses a previously undescribed mechanism to perform actin folding. The study was recently published in the journal Cell.

Actin is the most abundant protein in highly developed cells and has diverse functions in processes like cell stabilization, cell division and muscle...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Within reach of the Universe

08.08.2018 | Event News

A journey through the history of microscopy – new exhibition opens at the MDC

27.07.2018 | Event News

2018 Work Research Conference

25.07.2018 | Event News

 
Latest News

Quantum material is promising 'ion conductor' for research, new technologies

17.08.2018 | Materials Sciences

Low bandwidth? Use more colors at once

17.08.2018 | Information Technology

Protecting the power grid: Advanced plasma switch for more efficient transmission

17.08.2018 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>