Blocking IL1b with anakinra controls tumor-promoting inflammation in breast cancer
A cytokine signature found in certain kinds of breast cancer cells can not only serve as a diagnostic tool for HER2-negative cancers but also offer an effective treatment target.
Human breast cancer tissue stained by immunofluorescence illustrates the interplay between secreted and surface-bound TGFβ (red) expressed by cancer cells (blue), which primes tumor-infiltrating myeloid cells to produce IL1β (green). This in turn will lead to chronic inflammation associated with breast cancer progression. Gray, nuclei.
Credit: Jackson Laboratory
A research team led by Karolina Palucka, M.D., Ph.D., a professor at The Jackson Laboratory (JAX), has collaborated with researchers at The Baylor Institute for Immunology Research to show that IL1b, a member of the interleukin 1 family of cytokines (proteins released by certain cells of the immune system) drives the inflammation often found in cancer, and appears as an "IL1 signature" in women with HER2-negative metastatic breast cancer.
"We found that IL1b orchestrates tumor-promoting inflammation in breast cancer," Palucka says, "and its presence corresponds with poor clinical outcomes. We show that it can be effectively targeted in patients using anakinra, a naturally occurring IL1 receptor antagonist."
Anakinra is already widely used to treat autoimmune and autoinflammatory diseases, and is being tested as an adjunct therapy to reduce the inflammation of metastatic cancer, including metastatic colorectal cancer.
In the new study, 11 women with advanced metastatic HER2-negative breast cancer received anakinra treatment, and after just two weeks showed reduced gene expression of IL1b and other cytokines and signaling pathways.
The patients then received anakinra in combination with standard chemotherapeutics for HER2-negative cancers for a median duration of four months. Some patients reported less pain and increased quality of life during this combination treatment, and three of them are still alive.
The team's report appears as the cover article in the journal Cancer Research, along with a commentary by Charles A. Dinarello, Ph.D., of the University of Colorado Denver Anschutz Medical Campus, who discovered, cloned and characterized the essential biology of a human "fever molecule," which was later named Interleukin-1 (IL-1).
"The study represents several years of dedicated research on cancer by Palucka and colleagues," Dinarello writes. "Although there are several advantages of knowing a transcriptional signature, including risk and prognosis, a real benefit is the exploitation of the signature to develop specific, targeted therapies. In the case of patients with cancer with IL-1 signature genes, one could simply block IL1. In fact, this is exactly what the study accomplished."
email@example.com | EurekAlert!
Researchers find trigger that turns strep infections into flesh-eating disease
19.02.2019 | Houston Methodist
Loss of identity in immune cells explained
18.02.2019 | Technische Universität München
Up to now, OLEDs have been used exclusively as a novel lighting technology for use in luminaires and lamps. However, flexible organic technology can offer much more: as an active lighting surface, it can be combined with a wide variety of materials, not just to modify but to revolutionize the functionality and design of countless existing products. To exemplify this, the Fraunhofer FEP together with the company EMDE development of light GmbH will be presenting hybrid flexible OLEDs integrated into textile designs within the EU-funded project PI-SCALE for the first time at LOPEC (March 19-21, 2019 in Munich, Germany) as examples of some of the many possible applications.
The Fraunhofer FEP, a provider of research and development services in the field of organic electronics, has long been involved in the development of...
For the first time, an international team of scientists based in Regensburg, Germany, has recorded the orbitals of single molecules in different charge states in a novel type of microscopy. The research findings are published under the title “Mapping orbital changes upon electron transfer with tunneling microscopy on insulators” in the prestigious journal “Nature”.
The building blocks of matter surrounding us are atoms and molecules. The properties of that matter, however, are often not set by these building blocks...
Scientists at the University of Konstanz identify fierce competition between the human immune system and bacterial pathogens
Cell biologists from the University of Konstanz shed light on a recent evolutionary process in the human immune system and publish their findings in the...
Laser physicists have taken snapshots of carbon molecules C₆₀ showing how they transform in intense infrared light
When carbon molecules C₆₀ are exposed to an intense infrared light, they change their ball-like structure to a more elongated version. This has now been...
The so-called Abelian sandpile model has been studied by scientists for more than 30 years to better understand a physical phenomenon called self-organized...
11.02.2019 | Event News
30.01.2019 | Event News
16.01.2019 | Event News
21.02.2019 | Earth Sciences
21.02.2019 | Trade Fair News
21.02.2019 | Life Sciences