Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New breakthrough paving the way for universal Ebola therapeutic

08.05.2018

A new collaborative study has identified and studied Ebola antibodies that could be used to design universal therapeutics that are effective against many different Ebola species. The findings were recently published in Nature Microbiology.

The Ebola virus causes a severe illness with high mortality rates in humans. Several strategies have been developed to treat Ebola infection, including ZMapp, which has been shown to be effective in non-human primates and has been used under compassionate-treatment protocols in humans.


This is an Ebola photomicrograph.

Credit: The University of Texas Medical Branch at Galveston

"The trouble with ZMapp is that although it is effective against the Ebola species that was largely responsible for the last Ebola outbreak, it does not neutralize other Ebola species, including Ebola Bundibugyo, Reston or Sudan," said virologist Alex Bukreyev, co-senior author and a University of Texas Medical Branch at Galveston professor in the department of pathology.

"We identified and studied three naturally-occurring antibodies from human survivors of Ebola Bundibugyo that neutralize and protect against infection with the several different Ebola virus species."

The newly identified antibodies bond at a different site on the Ebola virus than other antibodies currently used to develop Ebola therapies.

Information on the Ebola virus:

According to the Centers for Disease Control, Ebola was first discovered in 1976 near the Ebola River in what is now the Democratic Republic of Congo. Since then, the virus has been infecting people from time to time, leading to outbreaks in several African countries.

Some of the different kinds of Ebola viruses are:

  • Ebola virus (Zaire ebolavirus)
  • Sudan virus (Sudan ebolavirus)
  • Taï Forest virus (Taï Forest ebolavirus, formerly Côte d'Ivoire ebolavirus)
  • Bundibugyo virus (Bundibugyo ebolavirus)
  • Reston virus (Reston ebolavirus), known to cause disease in nonhuman primates and pigs, but not in people

     

Other authors include UTMB's Natalia Kuzmina, Philipp linykh, Xiaoli Shen, Kai Huang, Palaniappan Ramanathan, Thomas Ksiazek and Alexander Bukreyev; Andrew Flyak, Pavlo Gilchuk, Christopher Gulka, Rebecca Lampley, Nurgun Kose, Hannah King, Gopal Sapparapu, David Wright and James Crowe, Jr. from Vanderbilt University; Charles Murin, Hannah Turner, Marnie Fusco, Erica Ollmann Saphire and Andrew Ward from The Scripps Research Institute as well as Christopher Bryan, Edgar Davidson and Benjamin Doranz from Integral Molecular, Inc.

The study was supported by the Defense Threat Reduction Agency and the National Institutes of Health.

Media Contact

Donna Ramirez
donna.ramirez@utmb.edu
409-772-8791

 @utmb_news

http://www.utmb.edu 

Donna Ramirez | EurekAlert!
Further information:
https://www.utmb.edu/newsroom/article11767.aspx

More articles from Health and Medicine:

nachricht Why might reading make myopic?
18.07.2018 | Universitätsklinikum Tübingen

nachricht Unique brain 'fingerprint' can predict drug effectiveness
11.07.2018 | McGill University

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: First evidence on the source of extragalactic particles

For the first time ever, scientists have determined the cosmic origin of highest-energy neutrinos. A research group led by IceCube scientist Elisa Resconi, spokesperson of the Collaborative Research Center SFB1258 at the Technical University of Munich (TUM), provides an important piece of evidence that the particles detected by the IceCube neutrino telescope at the South Pole originate from a galaxy four billion light-years away from Earth.

To rule out other origins with certainty, the team led by neutrino physicist Elisa Resconi from the Technical University of Munich and multi-wavelength...

Im Focus: Magnetic vortices: Two independent magnetic skyrmion phases discovered in a single material

For the first time a team of researchers have discovered two different phases of magnetic skyrmions in a single material. Physicists of the Technical Universities of Munich and Dresden and the University of Cologne can now better study and understand the properties of these magnetic structures, which are important for both basic research and applications.

Whirlpools are an everyday experience in a bath tub: When the water is drained a circular vortex is formed. Typically, such whirls are rather stable. Similar...

Im Focus: Breaking the bond: To take part or not?

Physicists working with Roland Wester at the University of Innsbruck have investigated if and how chemical reactions can be influenced by targeted vibrational excitation of the reactants. They were able to demonstrate that excitation with a laser beam does not affect the efficiency of a chemical exchange reaction and that the excited molecular group acts only as a spectator in the reaction.

A frequently used reaction in organic chemistry is nucleophilic substitution. It plays, for example, an important role in in the synthesis of new chemical...

Im Focus: New 2D Spectroscopy Methods

Optical spectroscopy allows investigating the energy structure and dynamic properties of complex quantum systems. Researchers from the University of Würzburg present two new approaches of coherent two-dimensional spectroscopy.

"Put an excitation into the system and observe how it evolves." According to physicist Professor Tobias Brixner, this is the credo of optical spectroscopy....

Im Focus: Chemical reactions in the light of ultrashort X-ray pulses from free-electron lasers

Ultra-short, high-intensity X-ray flashes open the door to the foundations of chemical reactions. Free-electron lasers generate these kinds of pulses, but there is a catch: the pulses vary in duration and energy. An international research team has now presented a solution: Using a ring of 16 detectors and a circularly polarized laser beam, they can determine both factors with attosecond accuracy.

Free-electron lasers (FELs) generate extremely short and intense X-ray flashes. Researchers can use these flashes to resolve structures with diameters on the...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Leading experts in Diabetes, Metabolism and Biomedical Engineering discuss Precision Medicine

13.07.2018 | Event News

Conference on Laser Polishing – LaP: Fine Tuning for Surfaces

12.07.2018 | Event News

11th European Wood-based Panel Symposium 2018: Meeting point for the wood-based materials industry

03.07.2018 | Event News

 
Latest News

Machine-learning predicted a superhard and high-energy-density tungsten nitride

18.07.2018 | Materials Sciences

NYSCF researchers develop novel bioengineering technique for personalized bone grafts

18.07.2018 | Life Sciences

Why might reading make myopic?

18.07.2018 | Health and Medicine

VideoLinks
Science & Research
Overview of more VideoLinks >>>