When evaluating early kidney injuries in people, doctors monitor blood level increases of creatinine, a waste product of muscle breakdown, to understand the severity of the injury. Creatinine is filtered by the kidneys, and small increases are an indication of early damage to vital kidney function.
For pets suffering critical illness or injury, University of Missouri researchers have found that even tiny increases of creatinine in blood also could indicate acute kidney damage. Using human blood measurement guidelines for acute kidney injuries, the researchers believe they can now help pet owners better know the severity of their animals’ illness.
“The concept of monitoring creatinine for kidney disease in dogs is not new to veterinary medicine,” said Marie Kerl, associate teaching professor in the department of veterinary medicine and surgery in the MU College of Veterinary Medicine. “Dog kidneys and human kidneys function the same way; there are only slight structural differences. In people hospitalized with any critical illness, acute kidney injury can develop even if kidney function was normal at admission. Doctors can determine whether kidney injury is occurring by seeing even very small increases in creatinine previously thought to be insignificant. We undertook a study to determine if critically ill dogs showed a similar risk of early kidney injury. If a pet is hit by a car or attacked by a larger animal causing multiple injuries, the kidneys are very susceptible to damage since 25 percent of an animal’s blood passes through the kidneys with every heartbeat.”
Kerl and her colleagues performed a retrospective study of creatinine change in 164 injured dogs admitted to the intensive care unit at the University of Missouri Veterinary Medical Teaching Hospital. Researchers compared the animal medical records and creatinine levels to criteria used to evaluate human acute kidney injury. The researchers then developed a veterinary acute kidney injury staging system, which would indicate to veterinarians how increases of creatinine correspond to the animal’s risk of death.
“One difference between human and animal medicine is that pet owners may have a different tolerance for how far they want to go with treatment,” Kerl said. “Cost is always a concern, and while some animals can get better, many animals with multiple injuries will not. This kidney evaluation staging system would be another way for veterinarians to share recommendations based on the probable outcomes.”
Kerl’s paper, “Characterization of acute kidney injury in hospitalized dogs and evaluation of a veterinary acute kidney injury staging system,” was published in the Journal of Veterinary Emergency and Critical Care. Co-authors include Meredith Thoen, who completed residency training in the MU Department of Veterinary Medicine and Surgery.
The research reported in the published paper is part of Mizzou Advantage, the five unique areas that set MU apart from other universities. The project contributes to the “One Health/One Medicine: The Convergence of Human and Animal Health,” which expands on MU’s pioneering work in the convergence of human and animal health and connects it with research and instruction in health care delivery, health policy, medical ethics, health care business models and the culture of healthy living.
Steven Adams | EurekAlert!
The genes are not to blame
20.07.2018 | Technische Universität München
Targeting headaches and tumors with nano-submarines
20.07.2018 | Universitätsmedizin der Johannes Gutenberg-Universität Mainz
A new manufacturing technique uses a process similar to newspaper printing to form smoother and more flexible metals for making ultrafast electronic devices.
The low-cost process, developed by Purdue University researchers, combines tools already used in industry for manufacturing metals on a large scale, but uses...
For the first time ever, scientists have determined the cosmic origin of highest-energy neutrinos. A research group led by IceCube scientist Elisa Resconi, spokesperson of the Collaborative Research Center SFB1258 at the Technical University of Munich (TUM), provides an important piece of evidence that the particles detected by the IceCube neutrino telescope at the South Pole originate from a galaxy four billion light-years away from Earth.
To rule out other origins with certainty, the team led by neutrino physicist Elisa Resconi from the Technical University of Munich and multi-wavelength...
For the first time a team of researchers have discovered two different phases of magnetic skyrmions in a single material. Physicists of the Technical Universities of Munich and Dresden and the University of Cologne can now better study and understand the properties of these magnetic structures, which are important for both basic research and applications.
Whirlpools are an everyday experience in a bath tub: When the water is drained a circular vortex is formed. Typically, such whirls are rather stable. Similar...
Physicists working with Roland Wester at the University of Innsbruck have investigated if and how chemical reactions can be influenced by targeted vibrational excitation of the reactants. They were able to demonstrate that excitation with a laser beam does not affect the efficiency of a chemical exchange reaction and that the excited molecular group acts only as a spectator in the reaction.
A frequently used reaction in organic chemistry is nucleophilic substitution. It plays, for example, an important role in in the synthesis of new chemical...
Optical spectroscopy allows investigating the energy structure and dynamic properties of complex quantum systems. Researchers from the University of Würzburg present two new approaches of coherent two-dimensional spectroscopy.
"Put an excitation into the system and observe how it evolves." According to physicist Professor Tobias Brixner, this is the credo of optical spectroscopy....
13.07.2018 | Event News
12.07.2018 | Event News
03.07.2018 | Event News
20.07.2018 | Power and Electrical Engineering
20.07.2018 | Information Technology
20.07.2018 | Materials Sciences