Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

MRSA rates varied dramatically across geographic areas

03.06.2014

Researchers studied LA, San Francisco, Chicago, New York and Raleigh-Durham

The rates of community-onset methicillin-resistant Staphylococcus aureus (CO-MRSA) varied dramatically among academic medical centers in California, New York, Illinois and North Carolina, suggesting there is not a uniform change in the "national epidemic" of the "superbug" that has generated extensive public health concern over the past decade, according to a new study.


Dr. Brad Spellberg, LA BioMed infectious disease specialist, says dramatic differences in the incidence and rate of change in the number of MRSA and MSSA infections indicate ongoing, fundamental changes in bacterial ecology.

Credit: LA BioMed

The study, published online ahead of print in the journal Clinical Infectious Diseases, surveyed hospital records of 4,171 cases of MRSA and MRSA-related infections between 2008 and 2011 in five medical centers located in Los Angeles, San Francisco, Chicago, New York City and Raleigh-Durham, NC.

The rates of MRSA acquired in the community declined 57% from 2008-2011 in the Los Angeles medical center. In contrast, CO-MRSA rates tripled at the New York medical center, while the rates remained stable in San Francisco, Chicago and Raleigh-Durham. At the same time, the rates for a MRSA-related infection, methicillin-susceptible S. aureus (MSSA), tended to change in the opposite direction from MRSA rates.

Since MRSA and MSSA rates moved in opposite directions, the authors concluded: "Enhanced infection control efforts are unlikely to account for such variation in community onset infection rates"

"These dramatic differences in the incidence and rate of change in the number of MRSA and MSSA infections indicate ongoing, fundamental changes in bacterial ecology, which need further study to protect public health," said Brad Spellberg, MD, a Los Angeles Biomedical Research Institute (LA BioMed) infectious disease specialist and senior author of the study. "Fully understanding MRSA, MSSA and other antibiotic-resistant infections is essential to finding new approaches to save the lives and protect the health of our patients here and around the world."

First recognized in the early 1960s, MRSA became a major public health concern in the late 1980s because it had become endemic in most U.S. hospitals. In the 1990s, a new wave of the antibiotic-resistant staph infections acquired in the community swept the nation. These were not caused by bacteria that had escaped from the hospital. They were MSSA strains with a novel resistance element. These MSSA strain types, especially the ones with a genetic background known as USA 300, were highly virulent. Driven by the emergence of USA300, the incidence of MRSA infections rose dramatically in the 2000s.

In the mid-1990s, Los Angeles and Chicago were among the first regions in the country to be affected by the emergence of MRSA acquired in the community. The "epidemic" of these community-acquired antibiotic-resistant infections only recently reached New York, leading researchers to conclude that the relatively stable incidence of CO-MRSA in Chicago and the decline in Los Angeles will begin to be seen in East Coast cities in the near future.

"This study also found that more than half the MRSA cases involved the most virulent form of the bacteria, bacterium with the USA300 genetic background. But the incidence varied from 35% at one hospital to 80% at another," said Dr. Spellberg. "All these differences in rates suggest that the epidemiology and other factors of antibiotic resistance vary greatly, requiring further study to fully understand antibiotic-resistant bacteria."

###

Dr. Spellberg is the author of the book, "Rising Plague," which examined the rise of antibiotic resistant infections and the failure to develop new antibiotics to combat them. The other researchers engaged in the study were: Arnold S. Bayer, Loren G. Miller and Raul Macias-Gil, LA BioMed; Michael Z. David, Robert S. Daum, Alison Baesa, Susan Boyle-Vavra and Julia Sieth, University of Chicago; Henry F. Chambers and Joann Volinski, University of California, San Francisco; Vance G. Fowler, Jr. and Thomas H. Rude, Duke University Medical Center, and Belinda Ostrowsky and Philip Gialanella, Montefiore Medical Center/Albert Einstein College of Medicine in New York.

About LA BioMed

Founded in 1952, LA BioMed is one of the country's leading nonprofit independent biomedical research institutes. It has approximately 100 principal researchers conducting studies into cancer, inherited diseases, infectious diseases, illnesses caused by environmental factors and much more. It also educates young scientists and provides community services, including prenatal counseling and childhood nutrition programs. LA BioMed is academically affiliated with the David Geffen School of Medicine at UCLA and located on the campus of Harbor-UCLA Medical Center. For more information, please visit http://www.LABioMed.org

Laura Mecoy | Eurek Alert!

Further reports about: BioMed Biomedical MRSA MSSA Medical acquired antibiotic bacteria differences epidemic infections resistance virulent

More articles from Health and Medicine:

nachricht Bioinspired nanoscale drug delivery method developed by WSU, PNNL researchers
10.01.2019 | Washington State University

nachricht How herpesviruses shape the immune system
09.01.2019 | German Center for Infection Research

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Ultra ultrasound to transform new tech

World first experiments on sensor that may revolutionise everything from medical devices to unmanned vehicles

The new sensor - capable of detecting vibrations of living cells - may revolutionise everything from medical devices to unmanned vehicles.

Im Focus: Flying Optical Cats for Quantum Communication

Dead and alive at the same time? Researchers at the Max Planck Institute of Quantum Optics have implemented Erwin Schrödinger’s paradoxical gedanken experiment employing an entangled atom-light state.

In 1935 Erwin Schrödinger formulated a thought experiment designed to capture the paradoxical nature of quantum physics. The crucial element of this gedanken...

Im Focus: Nanocellulose for novel implants: Ears from the 3D-printer

Cellulose obtained from wood has amazing material properties. Empa researchers are now equipping the biodegradable material with additional functionalities to produce implants for cartilage diseases using 3D printing.

It all starts with an ear. Empa researcher Michael Hausmann removes the object shaped like a human ear from the 3D printer and explains:

Im Focus: Elucidating the Atomic Mechanism of Superlubricity

The phenomenon of so-called superlubricity is known, but so far the explanation at the atomic level has been missing: for example, how does extremely low friction occur in bearings? Researchers from the Fraunhofer Institutes IWM and IWS jointly deciphered a universal mechanism of superlubricity for certain diamond-like carbon layers in combination with organic lubricants. Based on this knowledge, it is now possible to formulate design rules for supra lubricating layer-lubricant combinations. The results are presented in an article in Nature Communications, volume 10.

One of the most important prerequisites for sustainable and environmentally friendly mobility is minimizing friction. Research and industry have been dedicated...

Im Focus: Mission completed – EU partners successfully test new technologies for space robots in Morocco

Just in time for Christmas, a Mars-analogue mission in Morocco, coordinated by the Robotics Innovation Center of the German Research Center for Artificial Intelligence (DFKI) as part of the SRC project FACILITATORS, has been successfully completed. SRC, the Strategic Research Cluster on Space Robotics Technologies, is a program of the European Union to support research and development in space technologies. From mid-November to mid-December 2018, a team of more than 30 scientists from 11 countries tested technologies for future exploration of Mars and Moon in the desert of the Maghreb state.

Close to the border with Algeria, the Erfoud region in Morocco – known to tourists for its impressive sand dunes – offered ideal conditions for the four-week...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Our digital society in 2040

16.01.2019 | Event News

11th International Symposium: “Advanced Battery Power – Kraftwerk Batterie” Aachen, 3-4 April 2019

14.01.2019 | Event News

ICTM Conference 2019: Digitization emerges as an engineering trend for turbomachinery construction

12.12.2018 | Event News

 
Latest News

A new twist on a mesmerizing story

17.01.2019 | Physics and Astronomy

Brilliant glow of paint-on semiconductors comes from ornate quantum physics

17.01.2019 | Materials Sciences

Drones shown to make traffic crash site assessments safer, faster and more accurate

17.01.2019 | Information Technology

VideoLinks
Science & Research
Overview of more VideoLinks >>>