Patients in intensive care units (ICU) are often administered antibiotics against ventilator-associated pneumonia, ‘to be on the safe side’. Dutch researcher Stefan Visscher has developed a model that can quickly establish whether or not a patient has pneumonia. This can prevent unnecessary treatment with antibiotics.
In his thesis Stefan Visscher studied 238 cases of antibiotic treatment of which – with hindsight – only 157 patients were actually suffering from pneumonia. An absence of suitable patient-friendly tests makes it difficult to determine with certainty whether or not a patient has developed pneumonia.
Visscher developed and tested a Bayesian network model, a probabilistic model, that can distinguish between patients that do and do not have ventilator-associated pneumonia (VAP). His model calculates the probability that an individual patient is suffering from pneumonia, predicts which bacteria has caused it and indicates which antibiotic can best be prescribed. This method is more reliable than the cultures on which physicians currently base their decisions. The data needed to make the probability calculations are automatically retrieved from the electronic patient file.
In his model Visscher processed the clinical data and other details of all ventilated ICU patients over a period of three years. The computer models were initially based on expert knowledge. At a later stage this was enhanced with ‘machine-learning’ techniques in order to optimise the reliability of the predictions where needed.Electronic patient file
The research was carried out within the ToKeN programme of NWO Division for Physical Sciences, www.nwo.nl/token.
Kim van den Wijngaard | alfa
Live probiotics can re-balance the gut microbiome and modify immune system response
20.11.2018 | Symprove
Purdue cancer identity technology makes it easier to find a tumor's 'address'
16.11.2018 | Purdue University
Max Planck researchers revel the nano-structure of molecular trains and the reason for smooth transport in cellular antennas.
Moving around, sensing the extracellular environment, and signaling to other cells are important for a cell to function properly. Responsible for those tasks...
Researchers at the University of New Hampshire have captured a difficult-to-view singular event involving "magnetic reconnection"--the process by which sparse particles and energy around Earth collide producing a quick but mighty explosion--in the Earth's magnetotail, the magnetic environment that trails behind the planet.
Magnetic reconnection has remained a bit of a mystery to scientists. They know it exists and have documented the effects that the energy explosions can...
Biochips have been developed at TU Wien (Vienna), on which tissue can be produced and examined. This allows supplying the tissue with different substances in a very controlled way.
Cultivating human cells in the Petri dish is not a big challenge today. Producing artificial tissue, however, permeated by fine blood vessels, is a much more...
Faster and secure data communication: This is the goal of a new joint project involving physicists from the University of Würzburg. The German Federal Ministry of Education and Research funds the project with 14.8 million euro.
In our digital world data security and secure communication are becoming more and more important. Quantum communication is a promising approach to achieve...
On Saturday, 10 November 2018, the research icebreaker Polarstern will leave its homeport of Bremerhaven, bound for Cape Town, South Africa.
19.11.2018 | Event News
09.11.2018 | Event News
06.11.2018 | Event News
20.11.2018 | Life Sciences
20.11.2018 | Life Sciences
20.11.2018 | Physics and Astronomy