The research, which has just been published in the journal Nature Genetics, shows that people who lack the genes LCE3B and LCE3C are more likely to be affected by psoriasis.
These two genes appear to be involved in the skin’s response to damage. When these genes are missing this may leave skin relatively unprotected against the sequence of damage and inflammation that leads to the development of this uncomfortable skin disease.
John Armour, Professor of Human Genetics in the Institute of Genetics, together with Master of Research student Emma Dannhauser, were involved because of their expertise in accurate measurement of gene numbers.
Professor Armour said: "Measuring gene numbers accurately is technically challenging but is necessary to demonstrate this kind of effect. This new report adds to the growing number of examples of disorders caused by variation in the number of genes, and suggests that there may be many more examples to come. What's especially interesting about this example is that in the UK lacking these genes is actually commoner than having them."
Around 30 per cent of people with psoriasis have a family history of the condition. It has long been known that genetic predisposition is an important cause of psoriasis, but it is only recently that scientists have begun to discover the exact nature of the variations that give rise to that predisposition.
The study is the result of an international collaboration led by Professor Xavier Estivill at Pompeu Fabra University in Barcelona, and involving scientists from Nottingham, Nijmegen, St Louis, San Francisco, Michigan, Seattle, Rome and Evry in France.
Psoriasis is a common skin condition affecting about two per cent of the UK population, and causes patches of scaly, itchy skin. It generally affects prominent areas such as the elbows and knees, and commonly affects the scalp, but can affect any part of the skin.
Last year Professor Armour headed a research project, also published in Nature Genetics, which showed that psoriasis risk was affected by variation in the number of beta-defensin genes — a gene known to trigger skin inflammation in response to infection. The research established that people with extra copies of the gene might be more prone to developing psoriasis.
Emma Thorne | alfa
Study tracks inner workings of the brain with new biosensor
16.08.2018 | Rheinische Friedrich-Wilhelms-Universität Bonn
Foods of the future
15.08.2018 | Georg-August-Universität Göttingen
There are currently great hopes for solid-state batteries. They contain no liquid parts that could leak or catch fire. For this reason, they do not require cooling and are considered to be much safer, more reliable, and longer lasting than traditional lithium-ion batteries. Jülich scientists have now introduced a new concept that allows currents up to ten times greater during charging and discharging than previously described in the literature. The improvement was achieved by a “clever” choice of materials with a focus on consistently good compatibility. All components were made from phosphate compounds, which are well matched both chemically and mechanically.
The low current is considered one of the biggest hurdles in the development of solid-state batteries. It is the reason why the batteries take a relatively long...
New design tool automatically creates nanostructure 3D-print templates for user-given colors
Scientists present work at prestigious SIGGRAPH conference
Most of the objects we see are colored by pigments, but using pigments has disadvantages: such colors can fade, industrial pigments are often toxic, and...
Scientists at the University of California, Los Angeles present new research on a curious cosmic phenomenon known as "whistlers" -- very low frequency packets...
Scientists develop first tool to use machine learning methods to compute flow around interactively designable 3D objects. Tool will be presented at this year’s prestigious SIGGRAPH conference.
When engineers or designers want to test the aerodynamic properties of the newly designed shape of a car, airplane, or other object, they would normally model...
Researchers from TU Graz and their industry partners have unveiled a world first: the prototype of a robot-controlled, high-speed combined charging system (CCS) for electric vehicles that enables series charging of cars in various parking positions.
Global demand for electric vehicles is forecast to rise sharply: by 2025, the number of new vehicle registrations is expected to reach 25 million per year....
17.08.2018 | Event News
08.08.2018 | Event News
27.07.2018 | Event News
20.08.2018 | Information Technology
20.08.2018 | Life Sciences
20.08.2018 | Information Technology