Men with low levels of DHEA in the blood run an increased risk of developing coronary heart disease events. The Sahlgrenska Academy study has been published in the Journal of the American College of Cardiology.
The term prohormone refers to the precursor of a hormone. DHEA is a prohormone that is produced by the adrenal glands and can be converted to active sex hormones. While the tendency of DHEA levels to fall with age was discovered long ago, the biological role of the prohormone is largely unknown.
Åsa Tivesten, Professor at the University of Gothenburg
University of Gothenburg
Researchers at Sahlgrenska Academy, University of Gothenburg, have now shown that elderly men with low levels of DHEA in the blood run an increased risk of developing coronary heart disease events.
Lower level - greater risk
The study—which monitored 2,614 men age 69-80 in Gothenburg, Uppsala and Malmö for five years—assessed DHEA levels. The findings demonstrated that the lower the DHEA level at the study start, the greater the risk of coronary heart disease events during the five-year follow-up.
“Endogenous production of DHEA appears to be a protective factor against coronary heart disease,” says Åsa Tivesten, who coordinated the study. “High DHEA levels may also be a biomarker of generally good health in elderly men.”
According to Professor Claes Ohlsson, "While the study establishes a clear correlation between DHEA in the blood and coronary heart disease, the discovery does not indicate whether or not treatment with DHEA will reduce the risk in individual patients."
“Dehydroepiandrosterone and its Sulfate Predict the 5-Year Risk of Coronary Heart Disease Events in Elderly Men” was published in the Journal of the American College of Cardiology on October 28.
Link to article: http:// http://content.onlinejacc.org/article.aspx?articleid=1918789
Åsa Tivesten, Professor at the Sahlgrenska Academy and the Wallenberg Laboratory, University of Gothenburg
Phone: +46 31-3422913
Cell: +46 73-8005250
Approximately 1.4 million Swedes are estimated to have coronary heart disease. The condition is the most common cause of death in the country. Coronary heart disease patients live an average of 12-15 years longer than they did only 30 years ago.
—Swedish Heart-Lung Foundation
Henrik Axlid | idw - Informationsdienst Wissenschaft
The genes are not to blame
20.07.2018 | Technische Universität München
Targeting headaches and tumors with nano-submarines
20.07.2018 | Universitätsmedizin der Johannes Gutenberg-Universität Mainz
A new manufacturing technique uses a process similar to newspaper printing to form smoother and more flexible metals for making ultrafast electronic devices.
The low-cost process, developed by Purdue University researchers, combines tools already used in industry for manufacturing metals on a large scale, but uses...
For the first time ever, scientists have determined the cosmic origin of highest-energy neutrinos. A research group led by IceCube scientist Elisa Resconi, spokesperson of the Collaborative Research Center SFB1258 at the Technical University of Munich (TUM), provides an important piece of evidence that the particles detected by the IceCube neutrino telescope at the South Pole originate from a galaxy four billion light-years away from Earth.
To rule out other origins with certainty, the team led by neutrino physicist Elisa Resconi from the Technical University of Munich and multi-wavelength...
For the first time a team of researchers have discovered two different phases of magnetic skyrmions in a single material. Physicists of the Technical Universities of Munich and Dresden and the University of Cologne can now better study and understand the properties of these magnetic structures, which are important for both basic research and applications.
Whirlpools are an everyday experience in a bath tub: When the water is drained a circular vortex is formed. Typically, such whirls are rather stable. Similar...
Physicists working with Roland Wester at the University of Innsbruck have investigated if and how chemical reactions can be influenced by targeted vibrational excitation of the reactants. They were able to demonstrate that excitation with a laser beam does not affect the efficiency of a chemical exchange reaction and that the excited molecular group acts only as a spectator in the reaction.
A frequently used reaction in organic chemistry is nucleophilic substitution. It plays, for example, an important role in in the synthesis of new chemical...
Optical spectroscopy allows investigating the energy structure and dynamic properties of complex quantum systems. Researchers from the University of Würzburg present two new approaches of coherent two-dimensional spectroscopy.
"Put an excitation into the system and observe how it evolves." According to physicist Professor Tobias Brixner, this is the credo of optical spectroscopy....
13.07.2018 | Event News
12.07.2018 | Event News
03.07.2018 | Event News
20.07.2018 | Power and Electrical Engineering
20.07.2018 | Information Technology
20.07.2018 | Materials Sciences